Genprex (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, announced that research evaluating the company’s gene therapy for type 1 diabetes will be presented at the 16th International Conference on Advanced Technologies & Treatments for Diabetes (“ATTD”). The preclinical data will be presented by GNPX research collaborators at the University of Pittsburg. The conference will be held in Germany on Feb. 22 through 25, 2023. The presentation, which is titled “Pancreatic Intraductal Infusion of Adeno-Associated Virus to Treat Non-Human Primates in a Toxin-Induced Diabetes Model,” will be delivered by Ranjeet Kalsi, DO, who will be representing the laboratory of Dr. George Gittes, MD, a professor of surgery and pediatrics and chief of the Division of Pediatric Surgery at the University of Pittsburgh School of Medicine. The presentation is scheduled for Feb. 25 at 1:45 p.m. Central European Standard Time.
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About Genprex Inc.
Genprex is a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes. Genprex technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes, which currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. Genprex’s oncology program utilizes its proprietary, nonviral ONCOPREX(R) Nanoparticle Delivery System, which the company believes is the first systemic, gene-therapy delivery platform used for cancer in humans. ONCOPREX encapsulates the gene-expressing plasmids using lipid nanoparticles. The resultant product is then administered intravenously, where it is then taken up by tumor cells that express proteins that are deficient. The company’s lead product candidate, REQORSA (quaratusugene ozeplasmid), is being evaluated as a treatment for both non-small cell lung cancer (“NSCLC”), with each of its clinical programs receiving a fast track designation from the Food and Drug Administration, and small cell lung cancer. Genprex’s diabetes gene therapy approach is comprised of a novel infusion process that uses an endoscope and an adeno-associated virus (“AAV”) vector to deliver Pdx1 (“Pdx1”) and MafA (“MafA”) genes to the pancreas. In models of type 1 diabetes, the genes express proteins that transform alpha cells in the pancreas into functional beta-like cells, which can produce insulin but are distinct enough from beta cells to evade the body’s immune system. In type 2 diabetes, where autoimmunity is not at play, it is believed that exhausted beta cells are also rejuvenated and replenished. For more information, please visit the company’s website at www.Genprex.com
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