With the industry's largest network of sites, Florence sets a new benchmark for AI-enabled study startup, workflow automation, and operational risk management.

ATLANTA, GA / ACCESS Newswire / October 23, 2025 / Florence Healthcare reinforced its position as the global leader in clinical trial operations with a major milestone: Florence Trial Operations Platform now connects 65,000 study sites spanning more than 600 sponsors across 90+ countries, forming the industry's largest network. Recognized as the #1 clinical trial technology for six consecutive years, Florence continues to set the standard for startup speed, workflow automation, and operational risk management across sponsor study portfolios.

"Florence was built to bring sponsors and sites into a shared operational space," said Ryan Jones, CEO of Florence Healthcare. "First, we fully digitized startup to eliminate manual bottlenecks and paper workflows. Now, we're using AI to enhance speed and augment intelligence across 65,000 study sites globally - arming sponsors with portfolio-wide operational visibility so they can anticipate trial risk, act on insights, and drive execution on the ground."

Solving the $1 million per study problem

While digital-first sites set new standards for operational speed and efficiency, much of the industry still remains offline. Only 30% of global sites currently use an eISF, leaving roughly 200,000 sites dependent on inefficient paper processes for study startup, document collection and storage, regulatory process management, monitoring and closeout.

This lack of digitization costs sponsors an estimated $1 million per study in lost productivity, rework, quality and compliance risk.

Florence is closing this digital divide through the fastest growing clinical research network of 65,000 study sites and 600+ sponsors. By digitizing 100% of operational workflows, Florence sets the standard for startup speed, operational cost reduction, and risk control.

The results are compelling:

• Up to 70% faster last mile study startup operations compared to the average site startup time for a Top 10 global pharmaceutical sponsor.

• $141M annual operational cost takeout by automating site readiness workflows, based on active daily users and total hours saved per year across Florence's study site network.

• 51% increase in eTMF QA pass rates from 65% to 98.7%, due to built-in operational audits and automated compliance checks to control risk.

Shaping the Future of Study Operations

Florence is embedding AI across the study lifecycle to unlock operational data intelligence, recommend next-best actions, strengthen risk control, and improve operating efficiency.

Site Identification & Feasibility

Drawing on the industry's largest network of site intelligence, Florence enables sponsors and CROs to identify the most qualified sites by therapeutic area, geography, and performance, while AI-assisted feasibility surveys ensure faster, more accurate completion.

Study Startup

AI-enabled contracting and document exchange between eTMF and eISF automates SSU document exchange, while generative AI redlining shortens contract review cycles, compares terms in seconds, and dramatically reduces time to activation.

Remote Monitoring

AI-powered reporting surfaces early risk signals from operational audit trails and site data, providing real-time visibility and enabling proactive intervention. These insights minimize the need for on-site visits and ensure trials stay on schedule.

Together, these advancements move sponsors and CROs from manual oversight to intelligent execution across global study portfolios. Through its open API network, Florence rapidly integrates and extends its trial operation capabilities to other eClinical partner systems.

Florence AI operates at the speed of trust, ensuring every study remains fully aligned with FDA, EMA, HIPAA, GDPR, EU Annex 11, ICH E6 (R3), and GCP standards.

All capabilities will be available in December 2025.

Join the Movement: Research Revolution 2025

Florence will showcase its newest capabilities at Research Revolution 2025, the company's annual global event (October 26-28, 2025) bringing together sponsors, CROs, and research sites. Be part of the global revolution. Watch it live at: https://researchrevolutionsummit.com/live/

About Florence Healthcare

Florence is a purpose-built platform that connects sponsors and sites to accelerate clinical trials, improve operational capacity, and reduce risk. Designed for scale, Florence streamlines workflows, enhances collaboration, and delivers real-time visibility across studies-empowering research teams to move faster, stay inspection-ready, and increase trial throughput with fewer resources.

Contact Information

Seema Sheth-Voss
seema.shethvoss@florencehc.com
(888) 829-0896

SOURCE: Florence Healthcare