AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 14, 2003

                                                  REGISTRATION NO. 333-108191


                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                          AMENDMENT NO. 1. TO FORM S-3


             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                                  I-TRAX, INC.
                   ------------------------------------------
             (Exact name of registrant as specified in its charter)

                                    Delaware
                   ------------------------------------------
         (State or other jurisdiction of incorporation or organization)

                                   23-3057155
                   ------------------------------------------
                      (I.R.S. Employer Identification No.)

                          ONE LOGAN SQUARE, SUITE 2615
                               130 N. 18TH STREET
                        PHILADELPHIA, PENNSYLVANIA 19103
                                 (215) 557-7488
 -------------------------------------------------------------------------------
   (Address, including zip code, and telephone number, including are code, of
                    registrant's principal executive offices)

                                 FRANK A. MARTIN
                      CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                                  I-TRAX, INC.
                  ONE LOGAN SQUARE, SUITE 2615, 130 N. 18TH ST.
                             PHILADELPHIA, PA 19103
                               (215) 557-7488 x110
 -------------------------------------------------------------------------------
 (Name, address, including zip code, and telephone number, including are code,
                             of agent for service)

                                   COPIES TO:

YURI ROZENFELD, ESQ.                      JUSTIN P. KLEIN, ESQ.
GENERAL COUNSEL                           GERALD GUARCINI, ESQ.
I-TRAX, INC.                              BALLARD SPAHR ANDREWS & INGERSOLL, LLP
ONE LOGAN SQUARE, SUITE 2615              1735 MARKET STREET, 51ST FLOOR
130 N. 18TH ST.                           PHILADELPHIA, PA  19103
PHILADELPHIA, PA 19103                    (215) 665-8500
(215) 557-7488 x116

Approximate date of commencement of proposed sale to the public: As soon as
practicable after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plan, please check the following box. [ ]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [X]






If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

                        ________________________________

The registrant hereby amends the registration statement on such date or dates as
may be necessary to delay its effective date until the registrant shall file a
further amendment which specifically states that this registration statement
shall thereafter become effective in accordance with section 8(a) of the
Securities Act of 1933 or until the registration statement shall become
effective on such date as the Commission, acting pursuant to said section 8(a),
may determine.



                                       2



      The  information  in this  prospectus  is not  complete and may be changed
      without notice.  We may not issue these  securities until the registration
      statement filed with the Securities and Exchange  Commission is effective.
      This  prospectus is not an offer to sell these  securities  and we are not
      soliciting  offers to buy these securities in any  jurisdiction  where the
      offer or sale is not permitted.



                  SUBJECT TO COMPLETION, DATED OCTOBER 14, 2003


                                   PROSPECTUS

                                  I-TRAX, INC.


                                    1,628,298


                                    SHARES OF

                                  COMMON STOCK

         This prospectus relates to the offer and sale from time to time of the
following share held by the selling shareholders:


        o       up to 1,211,631 shares of our common stock; and


        o       up to 416,667  shares of common stock issuable upon the exercise
                of   outstanding   warrants  and  conversion  of  a  convertible
                promissory note.

          The prices at which selling  shareholders  may sell the shares will be
determined  by the  prevailing  market  price for the  shares  or in  negotiated
transactions.  We will  not  receive  any of the  proceeds  from the sale of the
shares.

          The  shares  offered  by this  prospectus  were  originally  issued in
connection with several private placements of our securities.


          Our common stock is listed on the American  Stock  Exchange  under the
symbol  "DMX." On October 13, 2003,  the closing  price for our common stock was
$3.66.


          Investing in our common stock involves  risks,  which are described in
the "Risk Factors" section beginning on page 6 of this prospectus.

                        ________________________________

          Neither  the  Securities   and  Exchange   Commission  nor  any  state
securities  commission  has  approved  or  disapproved  of these  securities  or
determined if this prospectus is truthful or complete. Any representation to the
contrary is a criminal offense.

                        ________________________________


                  The date of this Prospectus is ____ __, 2003







                                TABLE OF CONTENTS



Preliminary Notes.......................................................... 2
Statement Regarding Forward-Looking Information............................ 2
I-trax, Inc................................................................ 3
Risk Factors............................................................... 6
Market for Common Equity...................................................13
Use of Proceeds............................................................13
Selling Security Holders...................................................14
Plan of Distribution.......................................................16
Available Information......................................................17
Incorporation of Certain Documents by Reference............................17
Legal Matters..............................................................18
Experts....................................................................18



                                PRELIMINARY NOTES

          You should rely only on the information  contained and incorporated by
reference in this  prospectus.  No one has been  authorized  to provide you with
different  information.  This prospectus is not an offer of these  securities in
any state  where the offer is not  permitted.  You should  not  assume  that the
information contained and incorporated by reference in this prospectus or in any
prospectus  supplement  is  accurate  as of any date  other than the date on the
front of the document.

          Unless  otherwise  indicated,  references  to "we," "our" and "I-trax"
mean I-trax, Inc. and its subsidiaries.

          Effective January 3, 2003, we completed a 1-for-5 reverse stock split.
Our board of directors and  stockholders  authorized  the reverse stock split in
connection  with the then  pending  application  to list our common stock on the
American  Stock  Exchange.  Our common stock began trading on the American Stock
Exchange on January 15, 2003 under the symbol "DMX." The  information  presented
in this  prospectus  about the number of outstanding  shares of our common stock
and  historic  information  about our  common  stock and stock  prices  has been
adjusted to reflect the completed reverse stock split.

                 STATEMENT REGARDING FORWARD LOOKING INFORMATION

          This  prospectus  and our filings  with the  Securities  and  Exchange
Commission  (or  SEC)  incorporated  by  reference  in this  prospectus  include
forward-looking statements. All statements,  other than statements of historical
facts,  included in this prospectus and our filings with the SEC incorporated by
reference  in  this  prospectus  regarding  our  strategy,   future  operations,
financial  position,  future  revenues,  projected costs,  prospects,  plans and
objectives   of   management   are   forward-looking   statements.   The   words
"anticipates,"  "believes,"  "estimates,"  "expects," "intends," "may," "plans,"
"projects,"  "will,"  "would" and similar  expressions  are intended to identify
forward-looking statements,  although not all forward-looking statements contain
these  identifying  words. We cannot guarantee that we actually will achieve the
plans,  intentions or expectations  disclosed in our forward-looking  statements
and you should  not place  undue  reliance  on our  forward-looking  statements.
Actual results or events could differ materially from the plans,  intentions and
expectations  disclosed  in the  forward-looking  statements  we  make.  We have
included important factors in the cautionary statements included or incorporated
in this prospectus,  particularly  under the heading "Risk Factors" beginning on
page 6 below  that we believe  could  cause  actual  results or events to differ
materially  from the  forward-looking  statements we make.  Our  forward-looking
statements  do not  reflect  the  potential  impact of any future  acquisitions,
mergers, dispositions, joint ventures or investments we may make.

                                      -2-





                                  I-TRAX, INC.

Business Overview

         I-trax enables better healthcare through personalized health management
programs.

          We believe  that our  personalized  disease and  lifestyle  management
solutions  enable  organizations  to  evolve  from  fragmented  care  management
practices into a cohesive and efficient system of healthcare.  Our solutions are
fully integrated, use a single-data platform that allows all caregivers to share
records, and enable our clients to provide true coordination of care. We believe
that by facilitating  real-time  communication  between all stakeholders  within
today's complex  healthcare  system,  our solutions  reduce costs and enable the
best possible delivery of care.

          Health-e-LifeSM Program

          We deliver  our  solutions  through  our  proprietary  Health-e-LifeSM
Program.  The  Program  is  designed  to  deliver  lifestyle,  disease  and risk
reduction interventions to an entire population by utilizing predictive science,
technology, clinical expertise and personal care coordination.

          Predictive Science

          Our Health-e-LifeSM Program incorporates predictive science to analyze
our clients'  medical  claims and pharmacy and clinical  data to predict  future
healthcare  costs. We believe this is an essential step to effective disease and
lifestyle   management.   Experts  agree  that  predictive  science  provides  a
comprehensive  advantage to health plans, employers and providers,  and leads to
cost effective medical  management and greater  profitability.  Using predictive
science,  we analyze our clients' entire  populations to accurately  predict our
clients'  future  healthcare  costs,   including  avoidable  costs,  the  health
conditions  that will  drive  those  costs and the people  within  our  clients'
populations who are at risk for those  conditions.  Armed with this information,
I-trax is able to target the most  appropriate  resources  to  achieve  the best
savings and return on investment.

          Technology Solutions

          All technology  components of our  Health-e-LifeSM  Program  utilize a
single data platform--Medicive(R)  Medical Enterprise Data System--a proprietary
software architecture developed to collect,  store, retrieve and analyze a broad
range of information used in the healthcare industry.

          Further,   our  web  accessible  solutions  include  portals  for  key
stakeholders  in the  care  delivery  process--consumers,  physicians  and  care
managers--thus  permitting  real-time  sharing of  information  and  support the
adherence to our health and disease intervention programs. The key technology we
use for effective care coordination include:

        o       Health-e-Coordinator(TM),    a   web-based    care    management
                application;
        o       MyFamilyMD(TM), a consumer health management portal;
        o       CarePrime(R),  a clinical care  application  for  physicians and
                clinicians; and
        o       I-talk(TM), interactive smart voice technology.

          Interventions and Clinical Expertise

          Our personalized  health and disease  interventions  include intensive
programs for  individuals  who suffer from,  or are at high risk for,  active or
chronic  disease and  tailored  programs  for  individuals  who are at low risk.
Depending on the individual's  level of risk, our custom tailored  interventions
include self-help programs available through the web or person-assisted programs
administered through our Care Communication  Center, which is staffed by trained
nurses and other healthcare professionals 24 hours per day, 7 days per week. All
interventions   include  lifestyle  and  risk  reduction  programs  that  follow
evidence-based clinical guidelines to optimize health, fitness, productivity and
quality of life.


                                       -3-



          We have designed and are  implementing  interventions  for a number of
specific chronic conditions,  including congestive heart failure (CHF), coronary
artery disease (CAD),  asthma,  diabetes,  cancer  management,  cystic fibrosis,
lower back pain and chronic obstructive pulmonary disease (COPD).

          Care Communication Center

          Our Care  Communications  Center is staffed  with  trained  nurses and
other healthcare  professionals  24 hours per day, 7 days per week.  Through the
Center, we effect targeted interventions to improve the health management of the
populations we serve.  The Center helps consumers make informed  decisions about
their health and provides ongoing support for those with chronic  diseases.  Our
demand management and nurse triage services incorporate  nationally  recognized,
evidence-based  clinical  guidelines to ensure that all caregivers and consumers
are following the best practices.

          Everything we do is built on information, which drives decision-making
and results. Information guides the identification of consumers, the utilization
of  protocols   that  provide  high  quality  and  cost   effective   care,  the
communication  among the key  stakeholders  and ultimately the return on capital
invested in providing healthcare.  When all of these components are in place, we
believe  that  consumer  satisfaction  will  increase and the costs of providing
quality healthcare will decrease.

Corporate Information

         General

          Our principal  executive offices are located at One Logan Square,  130
N. 18th Street,  Suite 2615,  Philadelphia,  Pennsylvania  19103.  Our telephone
number is (215)  557-7488  and our fax number is (215)  557-7820.  We maintain a
website located at  http://www.i-trax.com.  Information contained on our website
is not part of this prospectus.

          We make our annual reports on Form 10-KSB,  quarterly  reports on Form
10-QSB  and  current  reports  on Form  8-K,  as well as any  amendments  to the
forgoing,  available  free of  charge  on our  website  as  soon  as  reasonably
practicable after they have been filed with the SEC. For a detailed  description
of our business you should read these reports and the other filings we make with
the SEC which are incorporated by reference in this prospectus.

          I-trax, Inc.--Holding Company

          I-trax was incorporated in the State of Delaware on September 15, 2000
at the  direction  of  the  board  of  directors  of  I-trax  Health  Management
Solutions,  Inc.  (or Health  Management),  I-trax's  then  parent  company.  On
February 5, 2001,  I-trax became the holding company of Health Management at the
closing of a  reorganization  pursuant  to Section  251(g) of  Delaware  General
Corporation  Law. The holding  company  reorganization  was described in greater
detail in  I-trax's  registration  statement  on Form S-4  (Registration  Number
333-48862), filed with the SEC on October 27, 2000. At the effective time of the
reorganization   all  of  the  stockholders  of  Health  Management  became  the
stockholders of I-trax and Health Management became a wholly owned subsidiary of
I-trax. Further, all outstanding shares of Health Management were converted into
shares of I-trax in a non-taxable transaction. Health Management no longer files
reports  with the SEC.  However,  I-trax does file reports with the SEC, and its
common stock is traded on the American Stock Exchange under the symbol "DMX."

          The holding  company  structure has allowed us greater  flexibility in
our  operations  and  expansion  and  diversification  plans,  including  in the
acquisition of WellComm  Group,  Inc. on February 6, 2002 and iSummit  Partners,
LLC, doing business as "MyFamilyMD," on February 7, 2001.

          I-trax  acquired  WellComm  effective  February  6, 2002 in a two-step
reorganization  pursuant  to a Merger  Agreement  dated  January 28, 2002 by and
among I-trax, WC Acquisition,  Inc., an Illinois  corporation and a wholly-owned
subsidiary of I-trax,  WellComm and WellComm's two principals.  The initial step
of the reorganization  transaction  involved a merger of WC Acquisition with and
into WellComm, in which merger WellComm continued as the surviving  corporation.
The second step of the reorganization transaction involved a statutory merger of
WellComm with and into I-trax, in which merger I-trax continued as the surviving
corporation.


                                      -4-




          At the closing of the  WellComm  merger,  we delivered to the WellComm
stockholders approximately $2,200,000 in cash and 1,488,000 shares of our common
stock,  and to each of two senior officers of WellComm options to acquire 56,000
shares of our common stock at a nominal exercise price. After the merger,  three
executive officers of WellComm joined us as senior executives and WellComm's two
principal stockholders were elected to our board of directors.

          We funded the  acquisition  of  WellComm  by selling a 6%  convertible
senior  debenture in the  aggregate  principal  amount of $2,000,000 to Palladin
Opportunity  Fund LLC pursuant to a Purchase  Agreement  dated as of February 4,
2002 between Palladin and us. Pursuant to the purchase agreement, we also issued
Palladin a warrant to purchase  up to 307,692  shares of our common  stock.  The
outstanding  principal and any interest  under the debenture are payable in full
on or before February 3, 2004. Further,  outstanding  principal and any interest
may be converted at any time at the election of Palladin  into our common stock.
The  conversion  price under the  debenture,  and the  exercise  price under the
warrant, is $1.75.

          I-trax  acquired  iSummit  effective  February  7, 2001 in an exchange
transaction  pursuant to a Contribution  and Exchange  Agreement dated September
22, 2000,  as amended,  by and among  iSummit,  I-trax,  Health  Management  and
iSummit's three members. I-trax issued 580,682 shares of common stock to acquire
iSummit (reflecting a post closing adjustments to the aggregate number of issued
shares effective as of December 31, 2001).

          I-trax Health Management Solutions, Inc.--Operating Subsidiary

          Health  Management  is a  predecessor  to I-trax and is our  operating
subsidiary.  It was  incorporated  in the  State of  Delaware  under the name of
Marmac  Corporation  in May 1969. In December  1979, it changed its name to Ibex
Industries International, Inc. On April 1, 1996, Health Management purchased the
assets  of  certain  physician  practices,  changed  its  name to  U.S.  Medical
Alliance,  Inc.,  and commenced  operations as a physician  practice  management
company.

          As U.S. Medical Alliance,  Health Management  completed one additional
physician practice  acquisition.  However, it did not have adequate liquidity or
capital resources to withstand the downturn in the physician practice management
industry, nor the ability to acquire profitable physician practices.  In January
1997, the board of directors of Health  Management,  in an effort to reorganize,
elected Frank A. Martin as its  President.  Mr. Martin  negotiated the return of
the previously  acquired physician practice assets to the physicians in exchange
for the cancellation of any Health Management  capital stock or notes associated
with those acquisitions.  Health Management changed its name to I-Trax.com, Inc.
in August 1999.

          Health Management merged with Member-Link  effective December 30, 1999
pursuant to a Merger  Agreement  dated as of December 14,  1999.  In the merger,
Health  Management  issued an aggregate of 1,554,368 shares (as adjusted) of its
common stock. On February 7, 2001,  Health  Management and I-trax  completed the
previously described holding company  reorganization.  Health Management assumed
its current name, I-trax Health Management Solutions, Inc., on March 21, 2001.



                                      -5-


                                  RISK FACTORS

          In addition to other information contain and incorporated by reference
in this prospectus,  you should  carefully  consider the following risks and the
other information in evaluating I-trax and its business. Our business, financial
condition and results of operations  could be materially and adversely  affected
by each of these risks.  Such an adverse  effect could cause the market price of
our common stock to decline, and you could lose all or part of your investment.

Risk Related to I-trax

         We have a history of operating losses and anticipate continued
         operating losses through the third quarter of 2003.

          We have used  substantial  cash to fund our operating  losses,  and we
have never earned a profit.  Through June 30, 2003, we have used approximately $
14.4 million of cash to fund our operating  activities.  Moreover,  we expect to
use  additional  cash to fund our operating  losses through the third quarter of
2003. Our ability to achieve profitability will depend, in part, on:

        o       the commercial success of our service and software applications;

        o       successful deployment and retention of our services and software
                applications by our customers; and

        o       our sales and marketing activities.

          The success of our business  model  depends on  attracting  customers,
such as public health agencies, hospitals, health plans, self-insured employers,
and colleges and universities,  to our population  health management  solutions.
Although  we believe  that this  business  model will be  successful,  we cannot
assure you that we will achieve or sustain  profitability  or that our operating
losses will not increase in the future.

         We will require additional capital to fund our operating losses and
         improve our products and services.

          Additional   funds  are  required  to  complete  our  planned  product
development  efforts,  expand our sales and marketing  activities,  and to cover
cash  shortfalls  until our  current and  projected  pipeline  materializes.  At
present,  we  expect  to  obtain  such  funds  from  operations  and  financings
activities.   Financing  activities  may  include  equity  or  debt  financings,
strategic  alliances  with  corporate  partners  and  others,  or through  other
sources.  We cannot provide assurance that additional  funding will be available
on acceptable terms, if at all. If adequate funds are not available, we may have
to delay,  scale-back or eliminate  certain aspects of our operations or attempt
to obtain funds  through  arrangements  with  collaborative  partners or others.
Moreover,  if we  continue  to have  operating  losses  and are unable to obtain
capital to cover them, we may be unable to remain in business. These results, in
turn,  could  cause  the   relinquishment  of  our  rights  to  certain  of  our
technologies,  products or potential markets,  dilution of your ownership in our
business,  or our loss of what we believe is a current competitive  advantage in
technology enabled population health management field. Therefore,  the inability
to obtain  adequate funds could have a material  adverse impact on our business,
financial condition and results of operations.

         The segment of the healthcare industry in which we operate is
         relatively new and our sales cycle is long and complex.

          The  disease  and  population  health  management  business,  although
growing rapidly,  is a relatively new segment of the overall healthcare industry
and has  many  entrants.  Many  companies  use the  generic  label  of  "disease
management" to characterize activities ranging from the sale of medical supplies
and drugs to services aimed at managing demand for healthcare services.  Because
this segment of the industry is relatively new, potential purchasers take a long
time to evaluate  and  purchase  such  services,  lengthening  our sales  cycle.
Further,  the sales and  implementation  process for our  services  and software
applications  is  lengthy,  involves  a  significant  technical  evaluation  and
requires our  customers to commit a great deal of time and money.  Finally,  the
sale and  implementation  of our  solutions  are  subject  to delays  due to our
customers'   internal   budgets  and  procedures  for


                                      -6-



approving  large  capital  expenditures  and deploying new services and software
applications  within  their  organizations.  The sales cycle for our  solutions,
therefore,  is  unpredictable  and has generally ranged from 3 to 24 months from
initial  contact  to  contract  signing.  The  time it takes  to  implement  our
solutions is also  difficult to predict and has lasted as long as 18 months from
contract execution to the commencement of live operation. During the sales cycle
and the implementation  period, we may expend substantial time, effort and money
preparing  contract  proposals,  negotiating the contract and  implementing  the
solution without receiving any related revenue.

         Our limited operating experience may cause us to misjudge the segment
         of the healthcare industry in which we are operating.

         We have only recently begun to design, build and offer disease
management and comprehensive health management solutions. Our enterprise
software applications have been operational for less than four years, our
web-based solutions have been operational for less than two years and our
disease management and comprehensive health management solutions have been
operational for only one year. Accordingly, we have a limited operating history
in our business. Furthermore, we are also facing other risks and challenges,
including a lack of meaningful historical financial data upon which to plan
future budgets, increasing competition, the need to develop strategic
relationships, and other risks described below. We cannot guarantee that we will
be able successfully to implement our business model. An investor in our common
stock must consider the risks, uncertainties, expenses and difficulties
frequently encountered by companies in their early stages of development. As a
result of the absence of meaningful history and experience in our business, we
may easily misjudge the nature or size of our perceived markets, or the amount
of work or capital necessary to complete our pending products or to implement
our business plan.

         We may be unable to implement our business strategy to deploy our
         products effectively and attract customers.

          Although we believe that there is significant  demand for our services
and products in the overall healthcare market, there are many reasons why we may
be unable to execute our business strategy, including our possible inability to:

        o       deploy our services and software applications on a large scale;

        o       attract a sufficiently  large number of public health  agencies,
                hospitals, health plans, self-insured employers and colleges and
                universities   to  subscribe   for  our  services  and  software
                applications;

        o       increase awareness of our brand;

        o       strengthen user loyalty;

        o       develop and improve our services and software applications;

        o       continue  to develop  and  upgrade  our  services  and  software
                applications; and

        o       attract, retain and motivate qualified personnel.

         The healthcare industry is subject to cost pressures.

          The healthcare  industry is currently  under pressure by  governmental
and private-sector  revenue sources to cut spiraling costs. These pressures will
continue  and  possibly  intensify.  Although we believe  that our  services and
software applications assist public health agencies, hospitals, health plans and
self-insured  employers to control the high costs  associated with the treatment
of chronic  diseases,  the pressures to reduce costs  immediately may hinder our
ability (or the length of time we require) to obtain new contracts. In addition,
the focus on cost reduction may pressure our customers to restructure  contracts
and reduce our fees.


                                      -7-


         Government regulation could adversely affect our business.


          Many of our existing and potential clients are subject to considerable
state and federal government regulations.  Many of these regulations are vaguely
written and subject to  differing  interpretations  that may, in certain  cases,
result in  unintended  consequences  that may affect our ability to  effectively
deliver our services.  Regulatory and legislative efforts currently focus on the
confidentiality of patient  identifiable  medical  information,  as evidenced by
such legislation as the Health Insurance  Portability and  Accountability Act of
1996  (or  HIPAA).   While  we  believe  that  our  ability  to  obtain  patient
identifiable medical information for disease management purposes from certain of
our clients is  protected in recently  released  federal  regulations  governing
medical record  confidentiality,  state  legislation or regulations will preempt
federal legislation if it is more restrictive. Accordingly, new federal or state
legislation or regulations  restricting the availability of this information for
disease management purposes would have a material negative effect on us.


          Although  we are not  directly  subject  to  many  of the  regulations
governing  healthcare  delivery,  our clients,  such as public health  agencies,
hospitals,   health  plans,  and  self-insured   employers,   must  comply  with
regulations  including the licensing and reimbursement  requirements of federal,
state  and local  agencies.  Further,  certain  of our  professional  healthcare
employees,  such as doctors and  nurses,  are  subject to  individual  licensing
requirements.  All of our healthcare  professionals who are subject to licensing
requirements  are  licensed in the state in which they are  physically  present.
Multiple state licensing  requirements for healthcare  professionals who provide
services  telephonically  over state lines may require us to license some of our
healthcare  professionals  in more than one state.  We  continually  monitor the
developments in telemedicine.  There is no assurance, however, that new judicial
decisions or federal or state  legislation or regulations would not increase the
requirement for multi-state  licensing of all central operating unit call center
health  professionals,  which would  significantly  increase our  administrative
costs.

          We are  indirectly  affected by changes in the laws  governing  health
plan,  hospital  and  public  health  agency  reimbursement  under  governmental
programs  such as Medicare  and  Medicaid.  There are periodic  legislative  and
regulatory  initiatives  to reduce the  funding  of the  Medicare  and  Medicaid
programs in an effort to curtail or reduce overall federal healthcare  spending.
Federal  legislation has and may continue to  significantly  reduce Medicare and
Medicaid  reimbursements  to most  hospitals.  These  reimbursement  changes are
negatively affecting hospital revenues and operations. There can be no assurance
that such legislative  initiatives or government regulations would not adversely
affect our operations or reduce demand for our services.

          Various  federal  and  state  laws  regulate  the  relationship  among
providers of healthcare  services,  other healthcare  businesses and physicians.
The "fraud and abuse"  provisions  of the Social  Security Act provide civil and
criminal  penalties  and  potential  exclusion  from the  Medicare  and Medicaid
programs  for  persons  or  businesses  who  offer,   pay,  solicit  or  receive
remuneration  in order to  induce  referrals  of  patients  covered  by  federal
healthcare  programs  (which  include  Medicare,  Medicaid,  TriCare  and  other
federally  funded  health  programs).  Although  we  believe  that our  business
arrangements with our clients are in compliance with these statutes, these fraud
and  abuse  provisions  are  broadly  written  and  the  full  extent  of  their
application is not yet known. We are therefore unable to predict the effect,  if
any, of broad enforcement interpretation of these fraud and abuse provisions.

         Our dependence on the Internet and Internet-related technologies
         subjects us to frequent change and risks.

          Our  web-based  software  applications  that form the  backbone of our
disease management and comprehensive  health management  solutions depend on the
continuous,  reliable  and secure  operation  of  Internet  servers  and related
hardware and software.  In the past,  several large Internet commerce  companies
have suffered highly  publicized  system  failures,  which depressed their stock
prices,  caused significant  negative publicity and sometimes led to litigation.
It is possible that we may also suffer service outages from time to time. To the
extent that our service is interrupted, our users will be inconvenienced and our
reputation may be diminished.  If access to our system becomes  unavailable at a
critical time,  users could allege we are liable,  which could depress our stock
price,  cause  significant  negative  publicity and possibly lead to litigation.
Although our computer and  communications  hardware is protected by physical and
software  safeguards,  it is still vulnerable to fire, storm, flood, power loss,
telecommunications  failures, physical or software break-ins and similar events.
We will not have 100%


                                      -8-


redundancy  for  all  of  our  computer  and  telecommunications  facilities.  A
catastrophic  event could have a  significant  negative  effect on our business,
results of operations, and financial condition.

          We also depend on third parties to provide certain of our clients with
Internet and online services necessary for access to our servers. It is possible
that our clients will  experience  difficulties  with  Internet and other online
services due to system failures,  including  failures  unrelated to our systems.
Any sustained disruption in Internet access provided by third parties could have
a material  adverse effect on our business,  results of operations and financial
condition.

          Finally, we retain confidential healthcare information on our servers.
It is, therefore,  critical that our facilities and infrastructure remain secure
and are  perceived  by clients to be secure.  Although we operate  our  software
applications  from a secure  facility  managed by a reputable  third party,  our
infrastructure  may be  vulnerable  to  physical  break-ins,  computer  viruses,
programming  errors or similar disruptive  problems.  A material security breach
could damage our reputation or result in liability to us.

         We may be sued by our users if we provide inaccurate health information
         on our website or inadvertently disclose confidential health
         information to unauthorized users.

          Because users of our website will access  health  content and services
relating to a medical  condition  they may have or may distribute our content to
others,  third  parties  may sue us for  defamation,  negligence,  copyright  or
trademark  infringement,  personal injury or other matters. We could also become
liable if confidential information is disclosed inappropriately.  These types of
claims have been brought, sometimes successfully, against online services in the
past.  Others  could  also sue us for the  content  and  services  that  will be
accessible  from our website  through links to other websites or through content
and materials that may be posted by our users in chat rooms or bulletin  boards.
Any such liability will have a material adverse effect on our reputation and our
business, results of operations or financial position.

         Our business will be adversely affected if we lose a key employee or
         fail to recruit and retain other skilled employee.

          Our  Chairman and Chief  Executive  Officer,  Frank A.  Martin,  is an
integral part of our business and our future  success  greatly  depends upon his
retention.  Our  failure to retain Mr.  Martin  could  significantly  reduce our
ability to compete and succeed in the future.

          Our future success also depends on our ability to attract,  retain and
motivate highly skilled employees.  As we secure new contracts and implement our
services  and  products,  we  will  need  to hire  additional  personnel  in all
operational areas. We may be unable to attract, assimilate or retain such highly
qualified  personnel.  We  have  in  the  past  experienced,  and we  expect  to
experience  in the future,  difficulty in hiring and  retaining  highly  skilled
employees with  appropriate  qualifications.  If we do not succeed in attracting
new personnel or retaining and  motivating our current  personnel,  our business
will be adversely affected.

         We may be unable to compete successfully against companies offering
similar products.

          Many healthcare companies are offering disease management services and
healthcare focused software solutions.  Further, a vast number of Internet sites
offer  healthcare  content,  products and  services.  In  addition,  traditional
healthcare  providers compete for consumers'  attention both through traditional
means as well as through  new  Internet  initiatives.  Although  we believe  our
technology-enabled   service   solutions   are  unique   and  better   than  our
competitors', we compete for customers with numerous other businesses.

         Many of these potential competitors are likely to enjoy substantial
competitive advantages compared to us, including:

        o       greater  name  recognition  and  larger  marketing  budgets  and
                resources;

        o       larger customer and user bases;


                                      -9-



        o       larger production and technical staffs;

        o       substantially greater financial,  technical and other resources;
                and

        o       a wider array of online products and services.

          To be  competitive,  we must  continue  to enhance  our  products  and
services,  as  well as our  sales  and  marketing  channels  and  our  financial
condition.

         We may be exposed to liability claims.

          We maintain professional malpractice, errors and omissions and general
liability insurance for all of our locations and operations. Although we believe
that these  insurance  policies  are  adequate  in amount and  coverage  for our
current  operations,  there can be no assurance  that  coverage is sufficient to
cover all future claims or will continue to be available in adequate  amounts or
at a reasonable cost.

          I-trax Health Management  Solutions,  Inc., our operating  subsidiary,
had  engaged in the  physician  practice  management  business.  While we are no
longer  engaged in that  business,  Health  Management may be subject to unknown
liabilities  arising  from  such  prior  business  operations,  which may have a
material adverse effect on our business,  operations,  financial  condition,  or
prospects.

          Member-Link  Systems,  Inc., a company we acquired in 1999 by way of a
merger with Health Management, was engaged in the business of marketing, selling
and installing eImmune(R) and AsthmaWatch(R)  applications.  Since beginning its
operations in 1996 until March 15, 2000,  Member-Link and Health  Management did
so without obtaining product or professional  liability insurance.  Accordingly,
if any customer of Member-Link or Health  Management  should in the future claim
that the software  applications  Member-Link and Health Management sold prior to
obtaining  insurance  on March 15,  2000 were  defective,  we would not have the
protection of insurance in satisfying or defending  against such claims. At this
time we are not aware of any such claims. Any such claims, however, could have a
material  adverse  effect on our  business,  results  of  operations,  financial
condition and prospects.

         Our clients may sue us if any of our software applications or services
is defective, fails to perform properly or injures the user. Even though we
currently have insurance, claims could require us to spend significant time and
money in litigation, to pay significant damages and to reserve for such
liability on our financial statements. At this time we are not aware of any such
claims. However, any such claims, whether or not successful, could seriously
damage our reputation and our business, results of operations or financial
position.

         If our intellectual property rights are undermined by third parties,
our business will suffer.

          Our intellectual  property is important to our business.  We rely on a
combination  of  copyright,  trademark  and trade secret  laws,  confidentiality
procedures and contractual  provisions to protect our intellectual property. Our
efforts  to  protect  our  intellectual  property  may  not  be  adequate.   Our
competitors  may  independently  develop  similar  technology  or duplicate  our
products or services.  Unauthorized  parties may infringe upon or misappropriate
our products, services or proprietary information. In addition, the laws of some
foreign countries do not protect  proprietary  rights as well as the laws of the
United  States do, and the global  nature of the Internet  makes it difficult to
control the ultimate  destination  of our products and services.  In the future,
litigation may be necessary to enforce our  intellectual  property  rights or to
determine the validity and scope of the proprietary  rights of others.  Any such
litigation would probably be  time-consuming  and costly. We could be subject to
intellectual property infringement claims as the number of our competitors grows
and the content and functionality of software  applications and services overlap
with  competitive  offerings.  Defending  against  these  claims,  even  if  not
meritorious,  could be expensive  and divert our  attention  from  operating our
company.  If we become liable to third parties for infringing their intellectual
property  rights,  we could be required to pay a  substantial  damage  award and
forced to develop  noninfringing  technology,  obtain a license or cease selling
the  applications  that contain the infringing  technology.  We may be unable to
develop noninfringing  technology or obtain a license on commercially reasonable
terms,  or at all. We also intend to rely on a variety of  technologies  that we
will  license from third  parties,  including  any database and Internet  server
software,  which will be used to operate  our  applications.  These  third-party
licenses



                                      -10-


may not be  available to us on  commercially  reasonable  terms.  The loss of or
inability  to  obtain  and  maintain  any of  these  licenses  could  delay  the
introduction of enhancements to our software applications, interactive tools and
other features until equivalent  technology could be licensed or developed.  Any
such  delays  could  materially  adversely  affect  our  business,   results  of
operations and financial condition.

         Provisions of our certificate of incorporation could impede a takeover
         of our company even though a takeover may benefit our stockholders.

          Our board of directors has the  authority,  without  further action by
the  stockholders,  to  issue  from  time to time,  up to  2,000,000  shares  of
preferred  stock in one or more  classes  or  series,  and to fix the rights and
preferences  of such preferred  stock.  We are subject to provisions of Delaware
corporate  law which,  subject  to certain  exceptions,  will  prohibit  us from
engaging  in  any  "business  combination"  with a  person  who,  together  with
affiliates and associates,  owns 15% or more of our common stock (referred to as
an interested  stockholder)  for a period of three years following the date that
such person became an interested stockholder, unless the business combination is
approved in a prescribed manner.  Additionally,  our bylaws establish an advance
notice  procedure for  stockholder  proposals and for nominating  candidates for
election as directors.  These  provisions of Delaware law and of our certificate
of  incorporation  and  bylaws  may have the effect of  delaying,  deterring  or
preventing a change in our control,  may discourage bids for our common stock at
a premium over market price and may adversely  affect the market price,  and the
voting and other rights of the holders of our common stock.

         Our officers and directors have effective control of the company and
         other stockholders may have little or no voice in corporate management.

          Our  Chairman,  the venture  capital  firm with which our  Chairman is
affiliated,  three  other  members  of our  management  team  and two  directors
beneficially own, in the aggregate,  approximately 30% of the outstanding shares
of  our  common  stock.  As  a  result,  these  stockholders,  acting  together,
effectively  control the election of directors and matters requiring approval by
our stockholders.  Thus, they may be able to prevent corporate transactions such
as future  mergers that might be favorable from our standpoint or the standpoint
of the other stockholders.

         The loss of any of our very limited number of customers will have a
         material adverse effect on our business.

          Historically,  a very limited  number of customers has accounted for a
significant  percentage of our revenues.  In 2001, our largest customer,  Walter
Reed Army  Medical  Center,  accounted  for 84% of our  revenues.  In 2002,  our
largest customers, UICI and Aetna Health Management,  Inc. accounted for 42% and
30% of our revenues,  respectively. We anticipate that our results of operations
in any given period will continue to depend to a significant extent upon a small
number of  customers.  Accordingly,  if we were to lose the  business  of even a
single  customer,  our results of operations  would be materially  and adversely
affected.

         If we cannot repay the debenture we sold to Palladin, we will be in
         default on a material obligation, which will cause us to suffer a
         material adverse event.

          We owe Palladin Opportunity Fund, LLC (or Palladin) $2,000,000 under a
6% convertible senior debenture.  If Palladin does not convert this sum into our
common stock,  this sum,  together with interest,  must be repaid on February 3,
2004. If we do not have  sufficient  funds to repay this sum on debenture's  due
date,  we will be in  default  on a  material  obligation  and as a  result  our
operations may be materially and adversely effected.

Investment Risks

         The price of our common stock is volatile.

          Our stock price has been and we believe will  continue to be volatile.
For example,  in 2002,  the per share price of our stock has  fluctuated  from a
high of $7.65 to a low of $2.50. The stock's volatility may be influenced by the
market's  perceptions of the healthcare  sector in general,  or other  companies
believed to be similar to us or by the market's perception of our operations and
future prospects. Many of these perceptions are beyond our control.


                                      -11-


In  addition,  our stock is not  heavily  traded and  therefore  the  ability to
achieve  relatively quick liquidity without a negative impact on our stock price
is limited.

         Shares eligible for future sale upon the conversion of the debenture
         and upon the exercise of issued options and warrants may cause
         significant dilution.

          Palladin  purchased from us a debenture  with the principal  amount of
$2,000,000.  The debenture and accrued  interest on the debenture is convertible
into such number of shares of our common  stock as  determined  by dividing  the
principal  amount and accrued  interest  thereon by the then current  conversion
price.  If  converted  on June  30,  2003,  the  debenture  would  convert  into
approximately 1,240,960 shares of our common stock. Our stockholders, therefore,
could experience  dilution of their investment upon conversion of the debenture.
The shares of common stock  issuable  upon the  conversion  of the debenture are
registered under the Securities Act of 1933, as amended (or Securities Act), and
may be sold by Palladin, subject to certain limitations, at any time.

          As of June 30,  2003,  approximately  5,489,092  shares of our  common
stock were reserved for issuance upon exercise of our  outstanding  warrants and
options in addition to the shares of our common stock reserved for issuance upon
the conversion of the debenture.

         We may need additional funds in the future which may not be available
         and which may result in dilution of the value of our common stock

          In the future, we may need to raise additional funds, which may not be
available on favorable  terms, if at all. If adequate funds are not available on
acceptable  terms,  we may be  unable  to fund our  business  growth  plans.  In
addition,  if funds are available,  the issuance of securities  could dilute the
value of shares of our common stock and cause the market price to fall.


                                      -12-




                           MARKET FOR OUR COMMON STOCK

          Our common  stock  trades on the  American  Stock  Exchange  under the
symbol  "DMX."  Prior to  January  15,  2003,  our  common  stock was  quoted on
Over-the-Counter  Bulletin  Board  under  the  symbol  "IMTX"  and  "ITRX."  The
following  table sets forth the high and low closing prices for our common stock
for the periods  indicated.  All closing  prices have been adjusted to reflect a
1-for-5 reverse stock split effected as of close of business on January 3, 2003.


                                                High                    Low
                                                ----                    ----
      2003
           Third Quarter                     $  3.790               $  2.600
           Second Quarter                       3.000                  1.510
           First Quarter                        5.000                  1.370


      2002
           Fourth Quarter                       4.300                  2.500
           Third Quarter                        5.100                  2.750
           Second Quarter                       6.625                  4.150
           First Quarter                        7.650                  5.100

      2001
           Fourth Quarter                       8.350                  1.800
           Third Quarter                        3.850                  1.800
           Second Quarter                       5.155                  2.900
           First Quarter                       15.000                  3.440

          We obtained the information presented above from Nasdaq.com.


          As of October  10,  2003,  there  were  approximately  480  registered
holders of our common stock.  On October 13, 2003, the last reported sales price
of our common stock was $3.66.


Dividend Policy

          We have never paid or declared any cash  dividends on our common stock
or  other  securities  and  do  not  anticipate  paying  cash  dividends  in the
foreseeable future.

                                 USE OF PROCEEDS

          We will not receive any proceeds from the sale of shares of our common
stock offered under this prospectus.  However,  we may receive proceeds from the
exercise of the warrants by the selling  shareholders,  which  proceeds  will be
used for general corporate purposes.




                                      -13-



                            SELLING SECURITY HOLDERS

         We are registering for offer and sale by the applicable holders:


        o       up to 1,211,631 shares of our common stock; and


        o       up to 416,667  shares of common stock issuable upon the exercise
                of   outstanding   warrants  and  conversion  of  a  convertible
                promissory note.

          The  selling  shareholders  may  offer  their  shares  for  sale  on a
continuous basis pursuant to Rule 415 under the Securities Act.


          All of the selling  shareholders'  shares  covered by this  prospectus
will become tradable upon  conversion on the effective date of the  registration
statement of which this prospectus is a part.


          Based on information provided to us by the selling  shareholders,  the
following table sets forth ownership and registration  information regarding the
shares held by the selling shareholders.





                                                     Number of
                                                     Shares of        Number of
                                                   Common Stock       Shares of         Common Stock Owned After
                                                   Owned Before      Common Stock         Offering Is Complete
Name of Selling Shareholder                        Offering (1)        Offered
                                                                                       Number of
                                                                                        Shares        Percentage
------------------------------------------------- -------------- ----------------- -------------- ----------------


                                                                                
Hans C. Kastensmith                                    465,828           420,114         45,714
The Del Mar Consulting Group, Inc.                     490,000           475,412         14,588
Joseph and Greta Shamy, JT (2)                         609,830           338,630         271,200       2.5%
Michael Steinberg (3)                                  125,000           125,000             --
Barry Honig (3)                                        125,000           125,000             --
Robert Prag                                             43,000            43,000             --
Andrew Friis                                            33,000            33,000             --
Jean F. Martin                                          42,500            20,000         22,500
Charles O. Howey Trust                                  20,000            20,000             --
Evan Taber                                               7,142             7,142             --
Marco Palatini                                           8,000             8,000             --
Marc Rubin                                               5,000             5,000             --
Mento Soponis                                            4,000             4,000             --
Leo C. Mueller, III                                      2,000             2,000             --
Leo C. Mueller, JR                                       2,000             2,000             --
                                                  ------------- ----------------- --------------

                                          TOTAL:     1,987,300         1,628,298        359,002





        (1)     The  actual  number of shares of common  stock  offered  in this
                prospectus,  and included in the registration statement of which
                this prospectus is a part,  includes such  additional  number of
                shares of common stock as may be issued or issuable by reason of
                any stock split, stock dividend or similar transaction involving
                the  common  stock,  in  accordance  with  Rule  416  under  the
                Securities Act.

        (2)     The aggregate  number of shares offered include 66,667 shares of
                common stock  issuable upon the conversion at $1.50 per share of
                a  convertible  promissory  note  in  the  principal  amount  of
                $100,000  and 100,000  share of common stock  issuable  upon the
                exercise of a warrant at $1.50 per share.

        (3)     The offered  shares are issuable  upon the exercise of a warrant
                at $1.50 per share.


                                      -14-




Material Relationships and Transactions


        o       Hans C.  Kastensmith  served as a director and vice  chairman of
                I-trax from  February 2001 through May 2002. Of the total shares
                to  be  offered  for  resale  by  Mr.   Kastensmith  under  this
                prospectus, Mr. Kastensmith acquired 285,714 shares in a private
                placement  initiated by I-trax on May 1, 2003 and closed on July
                2, 2003. In this private  placement,  I-trax issued an aggregate
                of  1,311,682  shares  of  common  stock at $1.75  per  share to
                approximately  16  participants.  We later refer to this private
                placement as the "Summer 2003 Private Placement." The balance of
                134,400 shares to be offered for resale by Mr. Kastensmith under
                this prospectus, Mr. Kastensmith acquired from third parties.

        o       The Del Mar Consulting  Group,  Inc.  provides I-trax consulting
                services  under a consulting  agreement.  The agreement has been
                effective  as of May 15,  2003 and  lasts  one  year.  Del Mar's
                services include  assisting I-trax with stockholder and investor
                communications, business strategy development and general public
                relations.  I-trax  common  stock held by Del Mar and covered by
                this  prospectus was issued to Del Mar as  compensation  for its
                services under the consulting  agreement.  Robert Prag exercises
                sole voting and dispositive powers with respect to the shares to
                be offered for resale by Del Mar under this prospectus. Mr. Prag
                also  acquired the I-trax shares to be offered by him for resale
                under this prospectus in the Summer 2003 Private Placement.

        o       Of the total shares to be offered for resale by Joseph and Greta
                Shamy under this prospectus, Mr. and Mrs. Shamy acquired 171,963
                shares in the Summer 2003 Private  Placement.  Of the  remaining
                balance,  66,667  shares are issuable  upon the  conversion of a
                convertible  promissory note in the principal amount of $100,000
                and 100,000  share are issuable  upon the exercise of a warrant.
                Mr. and Mrs. Shamy acquired the convertible  promissory note and
                warrant  pursuant to a  subscription  agreement  dated March 30,
                2003.  The  conversion  price under the  convertible  promissory
                note, and the exercise price under the warrant, is $1.50.

        o       Michael Steinberg  provides I-trax  consulting  services under a
                consulting agreement entered into as of June 2, 2003 and lasting
                a term of one year. Mr. Steinberg's  consulting services include
                assisting  I-trax with  introductions  to research  analysts and
                other members of the investment community. A warrant to purchase
                125,000  shares  of I-trax  common  stock at $1.50 per share was
                issued to Mr.  Steinberg as compensation  for his services under
                the  consulting  agreement.  The  warrant is  exercisable  for 5
                years.

        o       Barry  Honig  provides  I-trax   consulting   services  under  a
                consulting agreement entered into as of June 2, 2003 and lasting
                a term of one year.  Mr.  Honig's  consulting  services  include
                assisting  I-trax with  introductions  to research  analysts and
                other members of the investment community. A warrant to purchase
                125,000  shares  of I-trax  common  stock at $1.50 per share was
                issued to Mr. Honig as  compensation  for his services under the
                consulting  agreement.  The warrant is exercisable  for 5 years.
                Mr. Honig is an affiliate  of a  registered  broker-dealer.  Mr.
                Honig  acquired the warrant  covering the shares of common stock
                offered  under  this  prospectus  for  resale  in  his  personal
                ordinary  course  of  business.  Mr.  Honig  had no  agreements,
                arrangements or  understandings  with any other persons,  either
                directly or indirectly, to dispose of I-trax securities.

        o       Jean F. Martin is the mother of Frank A. Martin, chief executive
                officer and director of I-trax. Mr. Martin exercises  investment
                control and thus dispositive  power over the I-trax common stock
                owned by his mother. The shares to be offered for resale by Mrs.
                Martin under this  prospectus  were purchased by Mrs.  Martin in
                the Summer 2003 Private Placement.

        o       Each of  Andrew  Friis  and  Evan  Taber  is an  affiliate  of a
                registered broker-dealer. Each acquired the shares to be offered
                for resale  under this  prospectus  in the Summer  2003  Private
                Placement  and for  resale in his  personal  ordinary  course of
                business.   Neither  of  these   individuals   had   agreements,
                arrangements or  understandings  with any other persons,  either
                directly or indirectly, to dispose of I-trax securities.



                                      -15-




        o       Charles  O. Howey  Trust,  Marco  Palatini,  Marc  Rubin,  Mento
                Soponis, Leo C. Mueller, III and Leo C. Mueller, JR acquired the
                shares to be offered  for  resale  under  this  prospectus  in a
                private  placement  closed  in  January  2002.  In this  private
                placement,  I-trax  issued an aggregate  of 1,092,995  shares at
                $2.50 per share to approximately 50 participants.



                              PLAN OF DISTRIBUTION

          The  shares  being  offered  by  the  selling  shareholders  or  their
respective pledgees,  donees,  transferees or other successors in interest, will
be sold from time to time in one or more  transactions,  which may involve block
transactions:

        o       on the American  Stock Exchange or on such other market on which
                the common stock may from time to time be trading;

        o       in privately-negotiated transactions;

        o       through the writing of options on the shares;

        o       short sales; or

        o       any combination thereof.

         The sale price to the public may be:

        o       the market price prevailing at the time of sale;

        o       a price related to such prevailing market price;

        o       at negotiated prices; or

        o       such other price as the selling shareholders determine from time
                to time.

          The  shares  may  also  be sold  pursuant  to Rule  144.  The  selling
shareholders  shall  have the sole and  absolute  discretion  not to accept  any
purchase  offer or make any sale of shares if they deem the purchase price to be
unsatisfactory at any particular time.

          The  selling  shareholders  or  their  respective  pledgees,   donees,
transferees or other  successors in interest,  may also sell the shares directly
to market makers acting as  principals  or  broker-dealers  acting as agents for
themselves or their  customers.  These  broker-dealers  may be compensated  with
discounts,  concessions  or  commissions  from the selling  shareholders  or the
purchasers of shares for whom such  broker-dealers  may act as agents or to whom
they  sell  as  principal  or  both.  The   compensation   as  to  a  particular
broker-dealer  might be greater than  customary  commissions.  Market makers and
block  purchasers  purchasing the shares will do so for their own account and at
their own risk.  The selling  shareholders  may sell  shares of common  stock in
block  transactions  to market makers or other  purchasers at a price per share,
which may be below the then market price. The selling shareholders cannot assure
that all or any of the shares offered in this  prospectus  will be issued to, or
sold by, the selling  shareholders.  The selling  shareholders  and any brokers,
dealers or agents,  upon effecting the sale of any of the shares offered in this
prospectus,  may be  deemed  "underwriters"  as that term is  defined  under the
Securities Act or the  Securities  Exchange Act of 1934 (or Exchange Act) or the
rules and regulations under such acts.

          The selling shareholders,  alternatively,  may sell all or any part of
the  shares  offered  in this  prospectus  through  an  underwriter.  No selling
stockholder  has entered into any agreement with a prospective  underwriter  and
there is no assurance that any such agreement will be entered into. If a selling
shareholders  enters into such an agreement or agreements,  the relevant details
will be set forth in a supplement or revisions to this prospectus.


                                      -16-



          The selling  shareholders  and any other persons  participating in the
sale or distribution  of the shares will be subject to applicable  provisions of
the  Exchange  Act and  the  rules  and  regulations  under  the  Exchange  Act,
including,  without  limitation,  Regulation  M. These  provisions  may restrict
certain activities of, and limit the timing of purchases and sales of any of the
shares by, the selling shareholders or any other such person. Furthermore, under
Regulation M, persons  engaged in a  distribution  of securities  are prohibited
from simultaneously  engaging in market making and certain other activities with
respect  to  such  securities  for a  specified  period  of  time  prior  to the
commencement  of  such  distributions,   subject  to  specified   exceptions  or
exemptions. All of these limitations may affect the marketability of the shares.


                              AVAILABLE INFORMATION

          We file reports,  proxy statements and other  information with the SEC
(File  No.  0-30275).  Copies  of these  reports,  proxy  statements  and  other
information  may be  inspected  and  copied at the public  reference  facilities
maintained by the SEC at Judiciary  Plaza,  Room 1024,  450 Fifth Street,  N.W.,
Washington, D.C. 20549.

          Copies of these  materials  can also be obtained by mail at prescribed
rates from the Public  Reference  Section of the SEC,  450 Fifth  Street,  N.W.,
Washington,  D.C.  20549  or by  calling  the  SEC at  1-800-SEC-0330.  The  SEC
maintains  a  website  that  contains   reports,   proxy  statements  and  other
information   regarding   our   company.   The   address  of  this   website  is
http://www.sec.gov.

          We  have  filed  a  registration  statement  on  Form  S-3  under  the
Securities  Act with the SEC with  respect  to the  shares of our  common  stock
covered by this prospectus.  This document  constitutes the prospectus of I-trax
filed as part of that registration statement. This document does not contain all
of the information set forth in the registration statement because some parts of
the registration  statement are omitted as provided by the rules and regulations
of the SEC.  You may inspect and copy the  registration  statement at any of the
addresses listed above.


                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

          The following  documents we have filed with the SEC (File No. 0-30275)
pursuant to the Exchange Act are incorporated herein by reference:

        o       our Annual Report on Form 10-KSB for the year ended December 31,
                2002, filed on April 15, 2003,

        o       our amended  Quarterly  Reports on Form 10-QSB for the  quarters
                ended March 31, 2002, June 30, 2002 and September 30, 2002, each
                filed on May 15, 2003,

        o       our Quarterly  Report on Form 10-QSB for the quarter ended March
                31, 2003,  filed on May 15, 2003,  and our  Quarterly  Report on
                Form 10-QSB for the quarter ended June 30, 2003, filed on August
                14, 2003,

        o       our  Current  Reports on Form 8-K filed on  February  12,  2003,
                February 19, 2003,  April 22, 2003,  May 19, 2003 and August 15,
                2003,

        o       the description of our common stock,  $0.01 par value per share,
                and associated rights,  contained in our registration  statement
                on Form 8-A, filed on January 14, 2003,  including any amendment
                or report  filed for the purpose of updating  this  description,
                and

        o       all reports and other documents filed by us pursuant to Sections
                13(a),  13(c), 14 or 15(d) of the Exchange Act subsequent to the
                date of this  prospectus  and  prior to the  termination  of the
                offering.

          Any  statement  contained in a document  incorporated  by reference in
this  prospectus  will  be  deemed  to be  incorporated  by  reference  in  this
prospectus  and to be part of this  prospectus  from the date of  filing  of the
document.  Any statement modified or superseded will not be deemed, except as so
modified or superseded, to constitute a part


                                      -17-


of this prospectus.  We will provide upon written or oral request without charge
to each person to whom this  prospectus is delivered a copy of any or all of the
documents which are  incorporated  in this  prospectus by reference  (other than
exhibits to those documents unless those exhibits are specifically  incorporated
by reference  into the documents  that this  prospectus  incorporates).  Written
requests for copies should be directed to I-trax, Inc., Investor Relations,  One
Logan Square, Suite 2615, 130 N. 18th Street, Philadelphia,  Pennsylvania 19103.
Our telephone number is (215) 557-7488.


                                  LEGAL MATTERS

         The validity of the shares of our common stock offered by this
prospectus will be passed upon for us by our Vice President, General Counsel and
Secretary.


                                     EXPERTS

          The financial statements  incorporated in this prospectus by reference
to the Annual Report on Form 10-KSB of I-trax,  Inc. for the year ended December
31, 2002 have been so incorporated in reliance on the reports of Goldstein Golub
Kessler LLP,  independent  accountants,  given on the  authority of said firm as
experts in auditing and accounting

          The financial statements  incorporated in this prospectus by reference
to the Annual Report on Form 10-KSB of I-trax,  Inc. for the year ended December
31,   2001  have  been  so   incorporated   in   reliance   on  the  reports  of
PricewaterhouseCoopers  LLP, independent accountants,  given on the authority of
said firm as experts in auditing and accounting.



                                      -18-








PART II  INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

          The  following  table  sets  forth the costs and  expenses  payable by
I-trax in  connection  with the sale of the  securities  being  registered.  All
amounts are estimates except the SEC registration fee:

          SEC registration fee                                     $  $373
          Printing and engraving expenses                            1,000
          Accounting fees and expenses                               6,000
          Attorneys' fees and expenses                               2,000
          Transfer agent's fees and expenses                         1,000
          Miscellaneous                                                627
                                                               ------------

                   Total:                                        $  11,000



ITEM 15. INDEMNIFICATION OF OFFICERS AND DIRECTORS

          Section 145(a) of the Delaware General Corporation Law provides that a
Delaware  corporation  may  indemnify  any  person  who was or is a party  or is
threatened to be made a party to any  threatened,  pending or completed  action,
suit or proceeding,  whether civil,  criminal,  administrative or investigative,
other  than an action by or in the  right of the  corporation,  by reason of the
fact that he is or was a director, officer, employee or agent of the corporation
or is or was serving at the request of the  corporation as a director,  officer,
employee  or agent of  another  corporation  or  enterprise,  against  expenses,
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in  connection  with such action,  suit or proceeding if he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests  of the  corporation  and,  with  respect  to any  criminal  action or
proceeding, had no cause to believe his conduct was unlawful.

          Section 145(b) of the Delaware General Corporation Law provides that a
Delaware  corporation  may  indemnify  any  person  who was or is a party  or is
threatened to be made a party to any threatened,  pending or completed action or
suit by or in the right of the corporation to procure a judgment in its favor by
reason of the fact that such  person  acted in any of the  capacities  set forth
above,  against expenses  actually and reasonably  incurred by him in connection
with the defense or  settlement of such action or suit if he acted in good faith
and in a manner  he  reasonably  believed  to be in or not  opposed  to the best
interests  of the  corporation,  except that no  indemnification  may be made in
respect of any claim,  issue or matter as to which such  person  shall have been
adjudged to be liable to the corporation  unless and only to the extent that the
court in which such action or suit was brought  shall  determine  that,  despite
such adjudication of liability, such person is fairly and reasonably entitled to
be indemnified for such expenses which the court shall deem proper.

          Section 145 of the Delaware  General  Corporation Law further provides
that to the extent a director  or  officer  of a Delaware  corporation  has been
successful  in the  defense of any  action,  suit or  proceeding  referred to in
subsections  (a) or (b) of Section 145 or in the defense of any claim,  issue or
matter  therein,  he shall be  indemnified  against any  expenses  actually  and
reasonably  incurred by him in connection  therewith;  that the  indemnification
provided for by Section 145 shall not be deemed exclusive of any rights to which
the  indemnified  party may be entitled  and the  corporation  may  purchase and
maintain insurance on behalf of a director or officer of the corporation against
any  liability  asserted  against him or incurred by him in any such capacity or
arising out of his status as such whether or not the corporation  would have the
power to indemnify him against such liabilities under Section 145.

          Section  102(b)(7) of the Delaware  General  Corporation Law permits a
Delaware corporation to include a provision in its Certificate of Incorporation,
and I-trax's  Certificate  of  Incorporation  contains such a provision,  to the



                                     -II-1-



effect that, subject to certain exceptions, a director of a Delaware corporation
is not personally  liable to the  corporation or its  stockholders  for monetary
damages for a breach of his fiduciary duty as a director.

          I-trax's   By-laws  also  provide  that  I-trax  shall  indemnify  its
directors and officers  and, to the extent  permitted by the Board of Directors,
I-trax's employees and agents, to the full extent permitted by and in the manner
permissible  under  the laws of the State of  Delaware.  In  addition,  I-trax's
By-laws  permit the Board of Directors to authorize  the Company to purchase and
maintain  insurance against any liability  asserted against any of the Company's
directors, officers, employees or agents arising out of their capacity as such.

ITEM 16. EXHIBIT


           NUMBER            EXHIBIT TITLE
           ------            -------------


            4.1**       Convertible  Promissory  Note of I-trax,  Inc. issued to
                        Joseph Shamy and Greta Shamy JT on March 30, 2003.

            4.2**       Warrant  certificate  of I-trax,  Inc.  issued to Joseph
                        Shamy and Greta Shamy JT on March 30, 2003.

            4.3**       Form of warrant  certificate of I-trax,  Inc.  issued to
                        each of Michael  Steinberg  and Barry  Honing on June 2,
                        2003.


            5*          Opinion  of  Vice   President,   General   Counsel   and
                        Secretary.

            23.1*       Consent  of  Vice   President,   General   Counsel   and
                        Secretary. (Included in Exhibit 5.)

            23.2**      Consent of Goldstein Golub Kessler LLP.

            23.3**      Consent of PricewaterhouseCoopers LLP.

            24          Power of Attorney. (Included in signature page.)


         _____________________________
         *                 Previously filed.
         **                Filed with this registration statement.


ITEM 17.          UNDERTAKINGS

         The undersigned registrant hereby undertakes to:

          (1) File, during any period in which it offers or sells securities,  a
post-effective   amendment  to  this  registration   statement  to  include  any
additional or changed material information on the plan of distribution.

          (2) For  determining  liability  under the Securities  Act, treat each
post-effective  amendment  as a new  registration  statement  of the  securities
offered,  and the offering of the securities at that time to be the initial bona
fide offering.

          (3) File a post-effective amendment to remove from registration any of
the securities that remain unsold at the end of the offering.

          Insofar  as   indemnification   for  liabilities   arising  under  the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the small business  issuer pursuant to the foregoing  provisions,  or
otherwise, the small business issuer has been advised that in the opinion of the
Securities and Exchange Commission such indemnification is against public policy
as expressed in the Act and is,  therefore,  unenforceable.  In the event that a
claim for  indemnification  against such liabilities  (other than the payment by
the small business issuer of expenses incurred or paid by a director, officer or
controlling person of the small business issuer in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection


                                     -II-2-


with the securities being registered,  the small business issuer will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.






                                     -II-3-




                                   SIGNATURES


          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements of filing of this Registration Statement on Form S-3 and has
duly  caused  this  registration  statement  to be singed  on its  behalf by the
undersigned, thereunto duly authorized in the City of Philadelphia, Commonwealth
of Pennsylvania on October 14, 2003.


                                       I-TRAX, INC.

                                       By:      /s/ Frank A. Martin
                                                -----------------------------
                                                Frank A. Martin, Chairman and
                                                Chief Executive Officer

                                       By:      /s/ William S. Wheeler
                                                --------------------------------
                                                William S. Wheeler,  Chief
                                                Financial Officer
                                                (Principal  Financial and
                                                Accounting Officer)

          In accordance  with the  requirements  of the  Securities Act of 1933,
this  Registration  Statement on Form S-3 was signed by the following persons in
the capacities and on the dates stated.

          Each person whose  signature  appears  below in so signing also makes,
constitutes  and  appoints  Frank A. Martin and  William S.  Wheeler and each of
them,  his  or  her  true  and  lawful  attorney-in-fact,  with  full  power  of
substitution,  for him or her in any and all capacities, to execute and cause to
be filed with the Securities and Exchange  Commission any and all amendments and
post-effective  amendments  to  this  Registration  Statement  and  any  related
registration statement (and any and all amendments and post-effective amendments
thereto)  contemplated by Rule 462 under the Securities Act of 1933, as amended,
in each case with exhibits  thereto and other documents in connection  therewith
and hereby  ratifies and confirms all that said  attorney-in-fact  or his or her
substitute or substitutes may do or cause to be done by virtue hereof.




Signature                                Title                                  Date
----------------------                   ---------------------------------      -----------------


                                                                                      
/s/ Frank A. Martin                      Chairman, Chief Executive Officer,     October 14, 2003
----------------------                   President and Director
Frank A. Martin

*                                        Director                               October 14, 2003
----------------------
John Blazek

*                                        Director                               October 14, 2003
----------------------
David R. Bock

*                                        Director                               October 14, 2003
----------------------
Philip D. Green

*                                        Director                               October 14, 2003
----------------------
Dr. Michael M.E. Johns

*                                        Director                               October 14, 2003
----------------------
Dr. Arthur N. Leibowitz

*                                        Director                               October 14, 2003
----------------------
Dr. David Nash

*                                        Director                               October 14, 2003
----------------------
John R. Palumbo

                                     -II-4-




*                                        Director                               October 14, 2003
----------------------
R. Dixon Thayer

/s/ William S. Wheeler                   Director                               October 14, 2003
----------------------
William S. Wheeler

*By: Frank A. Martin, Attorney in Fact.
     ---------------





                                     -II-5-