UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G
                              (Amendment No. 9)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                           RIGEL PHARMACEUTICALS, INC.
                    -----------------------------------------
                                (Name of Issuer)

                                  Common Stock
                    -----------------------------------------
                         (Title of Class of Securities)

                                    766559108
                    -----------------------------------------
                                 (CUSIP Number)


                                October 21, 2004
--------------------------------------------------------------------------------
             (Date of Event That Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         |_|      Rule 13d-1(b)

         |X|      Rule 13d-1(c)

         |_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





CUSIP No.  766559108                                                                     Page 2 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners                                                                                             
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California                                                                                                
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                                
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                                                    
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                              
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IA                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!






CUSIP No.  766559108                                                                     Page 3 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners II, Inc.                                                                                    
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California                                                                                                
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                                
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                              
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IA                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!







CUSIP No. 766559108                                                                      Page 4 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Partners, L.P..                                                                           
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103            EXIT FILING ---- Please see Attachment A                                      
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  PN                                                                                               
-------------------------------------------------------------------------------------------------------------------




CUSIP No. 766559108                                                                      Page 5 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Management Partners, L.P..                                                                        
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                       EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103            EXIT FILING ---- Please see Attachment A                                      
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  PN                                                                                               
-------------------------------------------------------------------------------------------------------------------






CUSIP No. 766559108                                                                      Page 6 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero Partners, LLC                                                                            
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103            EXIT FILING ---- Please see Attachment A                                      
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO                                                                                               
-------------------------------------------------------------------------------------------------------------------





CUSIP No. 766559108                                                                      Page 7 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Partners II, L.P.                                                                          
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103            EXIT FILING ---- Please see Attachment A                                      
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  PN                                                                                               
-------------------------------------------------------------------------------------------------------------------








CUSIP No. 766559108                                                                      Page 8 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Management II, LLC.                                                      
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                                
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                                                    
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO                                                                                               
-------------------------------------------------------------------------------------------------------------------






CUSIP No. 766559108                                                                      Page 9 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero BioPharma Partners II, LLC.                                                                      
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware                                                                                         
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO                                                                                               
-------------------------------------------------------------------------------------------------------------------




CUSIP No. 766559108                                                                        Page 10 of 21 Pages
                                                 
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Farah Champsi                                                                                             
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States                                                                                             
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power 780,103
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!




CUSIP No. 766559108                                                                      Page 11 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Jean Deleage                                                                                              
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States                                                                                             
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         29,038
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With                                                             EXIT FILING ---- Please see footnote 1
                                                     (7)      Sole Dispositive Power    29,038

                                                     (8)      Shared Dispositive Power  780,103 
                                                                        EXIT FILING ---- Please see footnote 1

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         809,141    EXIT FILING ---- Please see Attachment A and footnote 2                      
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         4.14%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote  1: Includes the 780,103 shares of Common Stock held by the funds
          affiliated with Alta Partners II. He beneficially owns 9,593 shares of
          Common Stock and Stock Options for 20,557 shares of Common Stock. See
          Attachment A.





CUSIP No. 766559108                                                                      Page 12 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Garrett Gruener                                                                                           
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States                                                                                             
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       -0-
Person With                                                                     EXIT FILING
                                                     (7)      Sole Dispositive Power    -0-

                                                     (8)      Shared Dispositive Power  -0- 
                                                                                EXIT FILING
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         -0-    EXIT FILING ---- Please see Attachment A and footnote 2                          
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         0%                EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!





CUSIP No. 766559108                                                                      Page 13 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alix Marduel                                                                                              
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States                                                                                             
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       780,103
Person With
                                                     (7)      Sole Dispositive Power    -0-
                                                        
                                                     (8)      Shared Dispositive Power  780,103

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         780,103           EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                  
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.99%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!





CUSIP No. 766559108                                                                      Page 14 of 21 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Guy Nohra                                                                                                 
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States                                                                                             
-------------------------------------------------------------------------------------------------------------------
                    EXIT FILING ---- Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         15,122
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power       -0-
Person With                                                                     EXIT FILING
                                                     (7)      Sole Dispositive Power    15,122

                                                     (8)      Shared Dispositive Power  -0- 
                                                                                EXIT FILING

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         15,122           EXIT FILING ---- Please see Attachment A                                                 
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

                                                                                                                   
-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         0.08%             EXIT FILING ---- Please see Attachment A                                       
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN                                                                                               
-------------------------------------------------------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!



Item 1.

(a)      Name of Issuer: Rigel Pharmaceuticals, Inc. ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

                  1180 Veterans Boulevard
                  South San Francisco, CA 94080

Item 2.

(a)      Name of Person Filing:

         Alta Partners ("AP")
         Alta Partners II, Inc. ("AP II")
         Alta California Partners, L.P. ("ACP")
         Alta California Management, L.P. ("ACMP")
         Alta Embarcadero Partners, LLC ("AEP")
         Alta BioPharma Partners II, L.P. ("ABP II")
         Alta BioPharma Management II, LLC ("ABMP II")
         Alta Embarcadero BioPharma Partners II, LLC ("AEBP II")
         Farah Champsi ("FC")
         Jean Deleage ("JD")
         Garrett Gruener ("GG")
         Alix Marduel ("AM")
         Guy Nohra ("GN")

(b)      Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

(c)      Citizenship/Place of Organization:


         Entities:         AP               California
                           AP II            California
                           ACP              Delaware
                           ACMP             Delaware
                           AEP              California
                           ABP II           Delaware
                           ABMP II          Delaware
                           AEBP II          California

         Individuals:      FC               United States
                           JD               United States
                           GG               United States
                           AM               United States
                           GN               United States


(d)      Title of Class of Securities: Common Stock


(e)      CUSIP Number: 766559108

Item 3.        Not applicable.

Item 4         Ownership.



                    EXIT FILING ---- Please see Attachment A
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                                                                                     
                               AP        AP II         ACP         ACMP          AEP        ABP II       ABMP II
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(a)     Beneficial          780,103     780,103      780,103     780,103       780,103      780,103      780,103
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(b)     Percentage of        3.99%       3.99%        3.99%       3.99%         3.99%        3.99%        3.99%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(c)     Sole Voting Power     -0-         -0-          -0-         -0-           -0-          -0-          -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Shared Voting       780,103     780,103      780,103     780,103       780,103      780,103      780,103
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Sole Dispositive      -0-         -0-          -0-         -0-           -0-          -0-          -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Shared              780,103     780,103      780,103     780,103       780,103      780,103      780,103
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

                            AEBP II        FC          JD           GG            AM          GN
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(a)     Beneficial          780,103     780,103      809,141       -0-         780,103      15,122
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(b)     Percentage of        3.99%       3.99%        4.14%       0.00%         3.99%        0.08%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

(c)     Sole Voting Power     -0-         -0-        29,038        -0-           -0-        15,122
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Shared Voting       780,103     780,103      780,103       -0-         780,103        -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Sole Dispositive      -0-         -0-        29,038        -0-           -0-        15,122
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

        Shared              780,103     780,103      780,103       -0-         780,103        -0-
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------


Item 5.        Ownership of Five Percent or Less of a Class

EXIT FILING

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Not applicable.


Item 7.        Identification and Classification of the Subsidiary Which 
               Acquired the Security Being Reported on By the Parent Holding
               Company.

Not applicable.

Item 8.        Identification and Classification of Members of the Group

No reporting person is a member of a group as defined in Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

By signing below we certify  that, to the best of our knowledge and belief,  the
securities  referred to above were acquired and are held in the ordinary  course
of business  and were not  acquired  and are not held for the purpose of or with
the  effect  of  changing  or  influencing  the  control  of the  issuer  of the
securities  and were not  acquired and are not held in  connection  with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement




                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:    November 1, 2004



                                                  
ALTA PARTNERS                                        ALTA CALIFORNIA PARTNERS, L.P.

                                                     By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:               /s/ Jean Deleage          
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage                   
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                        Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage                   
   -----------------------------------------        
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                     ALTA BIOPHARMA MANAGEMENT II, LLC
By: Alta BioPharma Management II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi                  
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel                   
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                     /s/ Guy Nohra                      
   -----------------------------------------         --------------------------------------------
         Jean Deleage                                                  Guy Nohra


         /s/ Garrett Gruener                                  /s/ Farah Champsi         
   -----------------------------------------         --------------------------------------------
         Garrett Gruener                                      Farah Champsi



                                   EXHIBIT A

                            AGREEMENT OF JOINT FILING



Date:    November 1, 2004


                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct. ALTA PARTNERS ALTA CALIFORNIA PARTNERS, L.P.



                                                  
                                                     By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:               /s/ Jean Deleage          
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage                   
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                        Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage                   
   -----------------------------------------     
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                     ALTA BIOPHARMA MANAGEMENT II, LLC
By: Alta BioPharma Management II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi                  
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel                   
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                     /s/ Guy Nohra                      
   -----------------------------------------         --------------------------------------------
         Jean Deleage                                         Guy Nohra


         /s/ Garrett Gruener                                  /s/ Farah Champsi         
   -----------------------------------------         --------------------------------------------
         Garrett Gruener                                      Farah Champsi



                         Attachment A ----- EXIT FILING

Alta Partners provides  investment  advisory services to several venture capital
funds including Alta California  Partners,  L.P. and Alta Embarcadero  Partners,
LLC. On 9/29/04,  Alta California  Partners,  L.P. net exercised its warrant for
33,947 shares of Common Stock into 25,052 shares of Common Stock,  and then sold
the shares on 9/30/04. On 9/29/04, Alta Embarcadero Partners,  LLC net exercised
its warrant for 776 shares of Common Stock into 573 shares of Common Stock,  and
then sold the  shares on  9/30/04.  As a result of the sale of the  stock,  Alta
California  Partners,   L.P.  and  Alta  Embarcadero  Partners,  LLC  no  longer
beneficially  own any securities in Rigel  Pharmaceuticals,  Inc. The respective
general  partners  and  members  of  Alta  California  Partners  L.P.  and  Alta
Embarcadero Partners,  LLC hold sole voting and investment power with respect to
the shares owned by the aforementioned funds.

Certain  principals  of Alta  Partners are general  partners of Alta  California
Management  Partners,  L.P.  (which  is a  general  partner  of Alta  California
Partners, L.P.), and members Alta Embarcadero Partners, LLC. As general partners
and members of such  funds,  they may be deemed to share  voting and  investment
powers  over the  shares  held by the funds.  The  principals  of Alta  Partners
disclaim  beneficial  ownership of all such shares held by the foregoing  funds,
except to the extent of their proportionate pecuniary interests therein.

Alta Partners II, Inc. provides  investment advisory services to several venture
capital funds  including Alta BioPharma  Partners II, L.P. and Alta  Embarcadero
BioPharma  Partners  II, LLC.  During the period of October  18-21,  2004,  Alta
BioPharma Partners II, L.P. and Alta Embarcadero BioPharma Partners II, LLC sold
the  following  shares:  




                      Holder                        Date of Sale            # of Shares Sold  
                      ------                        ------------            ----------------  
                                                                               
     Alta  BioPharma Partners II, L.P.                10/18/04                   18,712  
                                                      10/19/04                   25,994  
                                                      10/21/04                  171,299 
                                                                                -------
                                                                                216,005




                      Holder                         Date of Sale           # of Shares Sold
                      ------                         ------------           ----------------
                                                                               
     Alta Embarcadero BioPharma Partners II, LLC      10/18/04                     688
                                                      10/19/04                     956
                                                      10/21/04                   6,301
                                                                                 -----
                                                                                 7,945


As a result of the sales, Alta BioPharma Partners II, L.P. now beneficially owns
752,423 shares of Common Stock and Alta Embarcadero  BioPharma  Partners II, LLC
now beneficially owns 27,680 shares Common Stock. The managing directors of Alta
BioPharma Partners II, L.P. and managers of Alta Embarcadero  BioPharma Partners
II, LLC exercise sole voting and investment power in respect to the shares owned
by such funds.

Certain  principals  of Alta  Partners II, Inc.  are managing  directors of Alta
BioPharma  Management  II, LLC (which is the general  partner of Alta  BioPharma
Partners II, L.P.), and managers of Alta Embarcadero BioPharma Partners II, LLC.
As managing directors and managers of such entities, they may be deemed to share
voting and investment powers over the shares beneficially held by the funds. The
principals of Alta Partners II, Inc. disclaim  beneficial  ownership of all such
shares held by the foregoing funds,  except to the extent of their proportionate
pecuniary interests therein.


                                                     Page 1 of 2 of Attachment A


                            Attachment A (continued)

Mr. Jean Deleage,  Director, is a managing director of Alta BioPharma Management
II, LLC (which is the general partner of Alta BioPharma  Partners II, L.P.), and
a manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus he currently
shares  voting and  dispositive  powers over the 752,423  shares of Common Stock
beneficially owned by Alta BioPharma Partners II, L.P., and the 27,680 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
He  disclaims  beneficial  ownership  of  all  such  shares  held  by all of the
foregoing funds except to the extent of his  proportionate  pecuniary  interests
therein.  Mr. Deleage  beneficially  owns 9,593 shares of Common Stock. He holds
stock options for 20,557  shares of Common Stock:  options for 8,333 shares were
granted on June 30,  2004,  options for 8,333 shares were granted on January 26,
2004, options for 1,112 shares were granted on 7/28/03, options for 1,667 shares
were granted on June 26,  2003,  options for 556 shares were granted on June 20,
2002 and options for 556 shares were granted on July 19, 2001.

Ms. Farah Champsi is a managing  director of Alta  BioPharma  Management II, LLC
(which is the general partner of Alta BioPharma Partners II, L.P.) and a manager
of Alta Embarcadero BioPharma Partners II, LLC. Thus she currently shares voting
and  dispositive  powers over the 752,423  shares of Common  Stock  beneficially
owned by Alta BioPharma  Partners II, L.P. and the 27,680 shares of Common Stock
beneficially owned by Alta Embarcadero BioPharma Partners II, LLC. She disclaims
beneficial  ownership  of all such  shares  held by all of the  foregoing  funds
except to the extent of her proportionate pecuniary interests therein.

Mr. Garrett Gruener is a general partner of Alta California Management Partners,
L.P.  (which is the general  partner of Alta  California  Partners,  L.P.) and a
member of Alta Embarcadero  Partners,  LLC. He disclaims beneficial ownership of
all such shares held by all of the  foregoing  funds except to the extent of his
proportionate pecuniary interests therein.

Dr. Alix Marduel is a managing  director of Alta  BioPharma  Management  II, LLC
(which is the general partner of Alta BioPharma Partners II, L.P.) and a manager
of Alta Embarcadero BioPharma Partners II, LLC. Thus she currently shares voting
and  dispositive  powers over the 752,423  shares of Common  Stock  beneficially
owned by Alta BioPharma  Partners II, L.P. and the 27,680 shares of Common Stock
beneficially owned by Alta Embarcadero BioPharma Partners II, LLC. She disclaims
beneficial  ownership  of all such  shares  held by all of the  foregoing  funds
except to the extent of her proportionate pecuniary interests therein.

Mr. Guy Nohra is a general partner of Alta California Management Partners,  L.P.
(which is the general partner of Alta California  Partners,  L.P.). He disclaims
beneficial  ownership  of all such  shares  held by all of the  foregoing  funds
except to the extent of his proportionate pecuniary interests therein. The Nohra
Living Trust owns 11,442  shares of Common Stock and the Nohra 1996 Credit Trust
owns 3,680 shares of Common Stock.

Alta Partners and Alta Partners II, Inc. are venture capital firms that share an
office in San Francisco. Alta Partners is California Corporation.  Alta Partners
II,  Inc. is a  California  Corporation.  Alta  California  Partners,  L.P. is a
Delaware Limited  Partnership,  Alta Embarcadero  Partners,  LLC is a California
Limited  Liability  Company,  Alta  BioPharma  Partners  II,  L.P. is a Delaware
Limited  Partnership,  and Alta  Embarcadero  BioPharma  Partners  II,  LLC is a
California Limited Liability Company.





                                                     Page 2 of 2 of Attachment A