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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                               (Amendment No. 5)*


           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
              RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO
                           FILED PURSUANT TO 13d-2 (b)

                          RIGEL PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   766559108
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                 April 29, 2003
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

      |_|   Rule 13d-1(b)

      |X|   Rule 13d-1(c)

      |_|   Rule 13d-1(d)



* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                Page 1 of 18 pages


CUSIP No. 766559108                                           Page 2 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Partners
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & Footnote 1
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & Footnote 1
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 1------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 1:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.



CUSIP No. 766559108                                           Page 3 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Partners II, Inc.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A and Footnote 2
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A and Footnote 2
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 2------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 2:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 4 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta California Partners, L. P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & Footnote 3
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & Footnote 3
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 3------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 3:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 5 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta California Management Partners, L. P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & Footnote 4
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & Footnote 4
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 4------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 4:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 6 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Embarcadero Partners, LLC
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & footnote 5
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & footnote 5
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 5------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 5:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 7 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta BioPharma Partners II, L.P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & Footnote 6
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & Footnote 6
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 6------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 6:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 8 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta BioPharma Management Partners II, LLC.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & footnote 7
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & footnote 7
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 7------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 7:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                           Page 9 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Embarcadero BioPharma Partners II, LLC.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & footnote 8
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & footnote 8
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,210,601
------------------------Please see Attachment A and Footnote 8------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 8:    Includes  the  1,950,184  shares of Common  Stock and Warrants to
               purchase  260,417  shares  of  Common  Stock  held  by the  funds
               affiliated with Alta Partners and Alta Partners II. These numbers
               reflect the 1:9 Reverse Stock Split that was  effective  6/26/03.
               See Attachment A.




CUSIP No. 766559108                                          Page 10 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Farah Champsi
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               1,481,943
BENEFICIALLY            Please see Attachment A & footnote 9
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        1,481,943
                        Please see Attachment A & footnote 9
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,481,943
------------------------Please see Attachment A and Footnote 9------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      11.3%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 9:    Includes  the  1,256,249  shares of Common  Stock and Warrants to
               purchase  225,694  shares  of  Common  Stock  held  by the  funds
               affiliated  with Alta Partners II. These numbers  reflect the 1:9
               Reverse Stock Split that was effective 6/26/03. See Attachment A.




CUSIP No. 766559108                                          Page 11 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Jean Deleage
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        2,779
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               2,210,601
BENEFICIALLY            Please see Attachment A & footnote 10
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               2,779
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        2,210,601
                        Please see Attachment A & footnote 10
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      2,213,380
------------------------Please see Attachment A and Footnote 10-----------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      16.8%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 10:   Includes  the  1,950,184  shares of  Common  Stock,  Warrants  to
               purchase  260,417  shares of Common Stock,  and Stock Options for
               2,779  shares of Common  Stock.  These  numbers  reflect  the 1:9
               Reverse Stock Split that was effective 6/26/03. See Attachment A.




CUSIP No. 766559108                                          Page 12 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Garrett Gruener
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               728,658
BENEFICIALLY            Please see Attachment A & footnote 11
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        728,658
                        Please see Attachment A & footnote 11
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      728,658
------------------------Please see Attachment A and Footnote 11-----------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      5.5%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 11:   Includes  the  693,935  shares of Common  Stock and  Warrants  to
               purchase  34,723  shares  of  Common  Stock  held  by  the  funds
               affiliated  with Alta  Partners.  These  numbers  reflect the 1:9
               Reverse Stock Split that was effective 6/26/03. See Attachment A.




CUSIP No. 766559108                                          Page 13 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alix Marduel
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               1,481,943
BENEFICIALLY            Please see Attachment A & footnote 12
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        1,481,943
                        Please see Attachment A & footnote 12
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,481,943
------------------------Please see Attachment A and Footnote 12-----------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      11.3%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 12:   Includes  the  1,256,249  shares of Common  Stock and Warrants to
               purchase  225,694  shares  of  Common  Stock  held  by the  funds
               affiliated  with Alta Partners II. These numbers  reflect the 1:9
               Reverse Stock Split that was effective 6/26/03. See Attachment A.




CUSIP No. 766559108                                          Page 14 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Guy Nohra
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                            Please see Attachment A
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES               728,658
BENEFICIALLY            Please see Attachment A & footnote 13
  OWNED BY              --------------------------------------------------------
    EACH          7     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               -0-
    WITH                --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER
                        728,658
                        Please see Attachment A & footnote 13
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      728,658
------------------------Please see Attachment A and Footnote 13-----------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      5.5%
--------------------------Please see Attachment A-------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 13:   Includes  the  693,935  shares of Common  Stock and  Warrants  to
               purchase  34,723  shares  of  Common  Stock  held  by  the  funds
               affiliated  with Alta  Partners.  These  numbers  reflect the 1:9
               Reverse Stock Split that was effective 6/26/03. See Attachment A.




Item 1.

(a)      Name of Issuer: Rigel Pharmaceuticals, Inc. ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

                  1180 Veterans Boulevard
                  South San Francisco, CA 94080

Item 2.

(a)      Name of Person Filing:

         Alta Partners ("AP")
         Alta Partners II, Inc. ("AP II")
         Alta California Partners, L.P. ("ACP")
         Alta California  Management  Partners,  L.P.  ("ACMP")
         Alta Embarcadero Partners,  LLC ("AEP")
         Alta BioPharma Partners II, L.P. ("ABP II")
         Alta BioPharma  Management  Partners  II, LLC ("ABMP  II")
         Alta  Embarcadero BioPharma  Partners  II, LLC  ("AEBP  II")
         Farah  Champsi  ("FC")
         Jean Deleage  ("JD")
         Garrett  Gruener  ("GG")
         Alix Marduel ("AM")
         Guy Nohra ("GN")

 (b)     Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

 (c)     Citizenship/Place of Organization:


         Entities:         AP               California
                           AP II            California
                           ACP              Delaware
                           ACMP             Delaware
                           AEP              California
                           ABP II           Delaware
                           ABMP II          Delaware
                           AEBP II          California

         Individuals:      FC               United States
                           JD               United States
                           GG               United States
                           AM               United States
                           GN               United States


(d)      Title of Class of Securities: Common Stock

(e)      CUSIP Number: 766559108



Item 3.  Not applicable.

Item 4.  Ownership.
                             Please see Attachment A



             The numbers listed below reflect the 1:9 Reverse Stock Split effective June 26, 2003.
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                               AP        AP II         ACP         ACMP         AEP         ABP II       ABMP II
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                                                                                   
(a)     Beneficial         2,210,601   2,210,601   2,210,601    2,210,601    2,210,601    2,210,601     2,210,601
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of        16.8%       16.8%        16.8%       16.8%        16.8%         16.8%        16.8%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-         -0-          -0-         -0-          -0-           -0-          -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      2,210,601   2,210,601   2,210,601    2,210,601   2,210,601     2,210,601    2,210,601
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-         -0-          -0-         -0-          -0-           -0-          -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             2,210,601   2,210,601   2,210,601    2,210,601   2,210,601     2,210,601    2,210,601
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                            AEBP II        FC          JD           GG           AM           GN
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(a)     Beneficial         19,895,423  15,212,500  19,905,423   4,682,923    15,212,500    4,682,923
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of       16.5%       12.7%        16.5%        4.8%        12.7%         4.8%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-          -0-       10,000        -0-          -0-           -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      19,895,423  15,212,500  19,895,423   4,682,923    15,212,500    4,682,923
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-          -0-       10,000        -0-          -0-           -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             19,895,423  15,212,500  19,895,423   4,682,923    15,212,500    4,682,923
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

                             Please see Attachment A



Item 5.  Ownership of Five Percent or Less of a Class

Not Applicable.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person

Not applicable.




Item 7.  Identification and  Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parent Holding Company.

Not applicable.

Item 8.  Identification and Classification of Members of the Group

No   reporting   person  is  a  member  of  a  group  as   defined   in  Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.  Notice of Dissolution of Group

Not applicable.

Item 10. Certification

By signing below we certify  that, to the best of our knowledge and belief,  the
securities  referred to above were acquired and are held in the ordinary  course
of business  and were not  acquired  and are not held for the purpose of or with
the  effect  of  changing  or  influencing  the  control  of the  issuer  of the
securities  and were not  acquired and are not held in  connection  with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement




                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Date:    July 2, 2003


                                                           
ALTA PARTNERS                                                 ALTA CALIFORNIA PARTNERS, L.P.

                                                              By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                                     By:      /s/ Jean Deleage
         --------------------------------------                        --------------------------------------
         Jean Deleage, President                                       Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.                     ALTA EMBARCADERO PARTNERS, LLC


By:      /s/ Jean Deleage                                     By:      /s/ Jean Deleage
         --------------------------------------                        --------------------------------------
         Jean Deleage, General Partner                                 Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
         --------------------------------------
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                              ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC

By:      /s/ Farah Champsi                                    By:      /s/ Farah Champsi
         --------------------------------------                        --------------------------------------
         Farah Champsi, Managing Director                              Farah Champsi, Member

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC

By:      /s/ Farah Champsi                                             /s/ Alix Marduel
         --------------------------------------                        --------------------------------------
         Farah Champsi, Manager                                        Alix Marduel

         /s/ Jean Deleage                                              /s/ Guy Nohra
         --------------------------------------                        --------------------------------------
         Jean Deleage                                                  Guy Nohra

         /s/ Garrett Gruener                                           /s/ Farah Champsi
         --------------------------------------                        --------------------------------------
         Garrett Gruener                                               Farah Champsi




                                   EXHIBIT A

                           AGREEMENT OF JOINT FILING

Date: July 2, 2003

                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.




                                                           
ALTA PARTNERS                                                 ALTA CALIFORNIA PARTNERS, L.P.

                                                              By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                                     By:      /s/ Jean Deleage
         --------------------------------------                        --------------------------------------
         Jean Deleage, President                                       Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.                     ALTA EMBARCADERO PARTNERS, LLC


By:      /s/ Jean Deleage                                     By:      /s/ Jean Deleage
         --------------------------------------                        --------------------------------------
         Jean Deleage, General Partner                                 Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
         --------------------------------------
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                              ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC

By:      /s/ Farah Champsi                                    By:      /s/ Farah Champsi
         --------------------------------------                        --------------------------------------
         Farah Champsi, Managing Director                              Farah Champsi, Member

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC

By:      /s/ Farah Champsi                                             /s/ Alix Marduel
         --------------------------------------                        --------------------------------------
         Farah Champsi, Manager                                        Alix Marduel

         /s/ Jean Deleage                                              /s/ Guy Nohra
         --------------------------------------                        --------------------------------------
         Jean Deleage                                                  Guy Nohra

         /s/ Garrett Gruener                                           /s/ Farah Champsi
         --------------------------------------                        --------------------------------------
         Garrett Gruener                                               Farah Champsi




                                  Attachment A

On June 26, 2003, the funds  affiliated with Alta Partners and Alta Partners II,
Inc.  purchased  1,302,083  shares of Common  Stock and  Warrants to purchase of
260,417  shares  of  Common  Stock,  in  accordance  with the terms of the Rigel
Pharmaceuticals,  Inc.  Common  Stock and Warrant  Purchase  Agreement  that was
signed April 29, 2003.  Effective  June 26, 2003,  there was a 1:9 Reverse Stock
Split of Common Stock.  The numbers of shares listed on this attachment  reflect
the reverse stock split.

Alta Partners II, Inc. provides  investment advisory services to several venture
capital funds  including Alta BioPharma  Partners II, L.P. and Alta  Embarcadero
BioPharma  Partners II, LLC. On June 26, 2003, Alta BioPharma  Partners II, L.P.
purchased  1,088,432  shares of Common  Stock and  Warrants to purchase  217,686
shares of Common Stock for an aggregate  purchase  price of  $6,269,451.32,  and
Alta  Embarcadero  BioPharma  Partners II, LLC purchased 40,040 shares of Common
Stock and warrants to purchase  8,008  shares of Common Stock for the  aggregate
purchase price of $230,633.40.  As of June 26, 2003, Alta BioPharma Partners II,
L.P. beneficially owns 1,211,676 shares of Common Stock and warrants to purchase
217,686  shares of Common stock.  Alta  Embarcadero  BioPharma  Partners II, LLC
beneficially  owns 44,573  shares  Common Stock and  Warrants to purchase  8,008
shares of Common Stock.  The managing  directors of Alta BioPharma  Partners II,
L.P. and managers of Alta Embarcadero  BioPharma  Partners II, LLC exercise sole
voting and investment power in respect to the shares owned by such funds.

Certain  principals  of Alta  Partners II, Inc.  are managing  directors of Alta
BioPharma  Management  II, LLC (which is the general  partner of Alta  BioPharma
Partners II, L.P.), and managers of Alta Embarcadero BioPharma Partners II, LLC.
As managing directors and managers of such entities, they may be deemed to share
voting and investment powers over the shares beneficially held by the funds. The
principals of Alta Partners II, Inc. disclaim  beneficial  ownership of all such
shares held by the foregoing funds,  except to the extent of their proportionate
pecuniary interests therein.

Alta Partners provides  investment  advisory services to several venture capital
funds including Alta California  Partners,  L.P. and Alta Embarcadero  Partners,
LLC. On June 26, 2003, Alta California  Partners,  L.P. purchased 169,733 shares
of Common  Stock and Warrants to purchase  33,947  shares of Common Stock for an
aggregate  purchase  price  of  $977,675.08.   Alta  Embarcadero  Partners,  LLC
purchased  3,878  shares of Common  Stock and Warrants to purchase 776 shares of
Common Stock for an aggregate purchase price of $22,338.28. As of June 26, 2003,
Alta California Partners,  L.P. beneficially owns 678,436 shares of Common Stock
and  Warrants  to  purchase  33,947  shares of Common  Stock.  Alta  Embarcadero
Partners,  LLC  beneficially  owns 15,499 shares of Common Stock and Warrants to
purchase 776 shares of Common Stock. The respective general partners and members
of Alta California  Partners L.P. and Alta  Embarcadero  Partners,  LLC exercise
sole voting and investment power with respect to the shares owned by such funds.

Certain  principals  of Alta  Partners are general  partners of Alta  California
Management  Partners,  L.P.  (which  is a  general  partner  of Alta  California
Partners, L.P.), and members Alta Embarcadero Partners, LLC. As general partners
and members of such  funds,  they may be deemed to share  voting and  investment
powers  over the  shares  held by the funds.  The  principals  of Alta  Partners
disclaim  beneficial  ownership of all such shares held by the foregoing  funds,
except to the extent of their proportionate pecuniary interests therein.

On June 26, 2003, Mr. Jean Deleage, a director of Rigel  Pharmaceuticals,  Inc.,
was granted stock options to purchase 1,667 shares of Common Stock. In addition,
he holds  options  for 556 shares of Common  Stock  granted on June 20, 2002 and
options for 556 shares of Common  Stock  granted on July 19,  2001.  The options
vest 1/24th per month over a two-year  period  commencing  on the date of grant.
Mr. Deleage is a managing director of Alta BioPharma Management Partners II, LLC
(which is the general partner of Alta BioPharma Partners II, L.P.), a manager of
Alta  Embarcadero  BioPharma  Partners  II,  LLC,  a  general  partner  of  Alta
California  Management  Partners,  L.P.  (which is the  general  partner of Alta
California Partners, L.P.), and a member of Alta Embarcadero Partners, LLC. Thus
he currently  shares voting and dispositive  powers over the 1,429,362 shares of
Common Stock  beneficially owned by Alta BioPharma Partners II, L.P., the 52,581
shares of Common Stock beneficially owned by Alta Embarcadero BioPharma Partners
II,  LLC,  the  712,383  shares  of  Common  Stock  beneficially  owned  by Alta
California  Partners  L.P. and the 16,275  shares of Common  Stock  beneficially
owned by Alta Embarcadero Partners,

                                                     Page 1 of 2 of Attachment A



                            Attachment A (continued)

LLC. He  disclaims  beneficial  ownership  of all such shares held by all of the
foregoing funds except to the extent of his  proportionate  pecuniary  interests
therein..  The numbers  listed  above  reflect the 1:9 Reverse  Stock Split that
became effective June 26, 2003.

Ms. Farah Champsi is a managing director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares voting and dispositive  powers over the 1,429,362  shares of Common Stock
beneficially  owned by Alta BioPharma Partners II, L.P. and the 52,581 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein.  The numbers  listed  above  reflect  the 1:9 Reverse  Stock Split that
became effective June 26, 2003.

Mr. Garrett Gruener is a general partner of Alta California Management Partners,
L.P.  (which is the general  partner of Alta  California  Partners,  L.P.) and a
member of Alta Embarcadero Partners,  LLC. Thus he shares voting and dispositive
powers  over the  712,383  shares of  Common  Stock  beneficially  owned by Alta
California Partners L.P. and 16,275 shares of Common stock beneficially owned by
Alta  Embarcadero  Partners LLC. He disclaims  beneficial  ownership of all such
shares  held  by  all  of the  foregoing  funds  except  to  the  extent  of his
proportionate  pecuniary interests therein. The numbers listed above reflect the
1:9 Reverse Stock Split that became effective June 26, 2003.

Dr. Alix Marduel is a managing  director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares voting and dispositive  powers over the 1,429,362  shares of Common Stock
beneficially  owned by Alta BioPharma Partners II, L.P. and the 52,581 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein.  The numbers  listed  above  reflect  the 1:9 Reverse  Stock Split that
became effective June 26, 2003.

Mr. Guy Nohra is a general partner of Alta California Management Partners,  L.P.
(which is the general partner of Alta California Partners, L.P.). Thus he shares
voting  and  dispositive   powers  over  the  712,383  shares  of  Common  Stock
beneficially  owned by Alta  California  Partners  L.P. He disclaims  beneficial
ownership  of all such shares held by all of the  foregoing  funds except to the
extent of his  proportionate  pecuniary  interests  therein.  The numbers listed
above reflect the 1:9 Reverse Stock Split that became effective June 26, 2003.

Alta Partners and Alta Partners II, Inc. are venture capital firms that share an
office in San Francisco. Alta Partners is California Corporation.  Alta Partners
II,  Inc. is a  California  Corporation.  Alta  California  Partners,  L.P. is a
Delaware Limited  Partnership,  Alta Embarcadero  Partners,  LLC is a California
Limited  Liability  Company,  Alta  BioPharma  Partners  II,  L.P. is a Delaware
Limited  Partnership,  and Alta  Embarcadero  BioPharma  Partners  II,  LLC is a
California Limited Liability Company.

                                                     Page 2 of 2 of Attachment A