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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 3)*

                                  ASTRALIS LTD.
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                                (Name of Issuer)

                    Common Stock, par value $0.0001 per share
            (upon conversion of Series A Convertible Preferred Stock)
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                         (Title of Class of Securities)

                                     046352
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                                 (CUSIP Number)

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       DONALD NICHOLSON                               KATHRYN A. CAMPBELL, ESQ.
        SKYEPHARMA PLC                                   SULLIVAN & CROMWELL
        105 PICCADILLY                                     ST OLAVE'S HOUSE
   LONDON W1J 7NJ, ENGLAND                                9a IRONMONGER LANE
       +44 20 7491 1777                                LONDON EC2V 8EY, ENGLAND
                                                         +44 20 7710 6500

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            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                 April 30, 2002
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             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) 13d-1(g), check the following
box [__]

     NOTE: Schedules filed in paper format shall include a signed original and
     five copies of the schedule, including all exhibits. See Rule 13d-7 for
     other parties to whom copies are to be sent.

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* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                         (continued on following pages)



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1.       Name Of Reporting Persons/I.R.S. Identification Nos. of Above Persons
         (Entities Only)

         SkyePharma PLC/330387911
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2.       Check the Appropriate Box if a Member of a Group             (a)  [   ]
         (See Instructions)                                           (b)  [ X ]
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3.       SEC Use Only

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4.       SOURCE OF FUNDS (See Instructions)
         WC
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5.       Check  if Disclosure of Legal Proceedings is Required
         Pursuant to Item 2(d) or 2(e)                                     [   ]
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6.       Citizenship or Place of Organization
         England and Wales
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                            7.     Sole Voting Power
                                   0
                           -----------------------------------------------------
         NUMBER OF          8.     Shared Voting Power
          SHARES                   33,020,000 (1)(2)
    BENEFICIALLY OWNED     -----------------------------------------------------
     BY EACH REPORTING      9.     Sole Dispositive Power
          PERSON                   8,220,000 (2)
                           -----------------------------------------------------
                            10.    Shared Dispositive Power
                                   0
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11.      Aggregate Amount Beneficially Owned by Each Reporting Person
         8,220,000 (1)(2)
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12.      Check  if the Aggregate Amount In Row (11) Excludes Certain Shares
         (See Instructions)                                                [ X ]
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13.      Percent of Class Represented by Amount in Row (11)
         18.0% (2)(3)
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14.      Type of Reporting Person (See Instructions)
         CO
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------------------------------------

1     In order to facilitate the consummation of the transaction contemplated by
      the Purchase Agreement by and between Astralis Ltd. and SkyePharma PLC,
      dated as of December 10, 2001 (the "Purchase Agreement"), Astralis Ltd.
      and SkyePharma PLC entered into a Stockholders Agreement between
      SkyePharma PLC, Astralis Ltd. and the other parties listed therein, dated
      as of December 10, 2001 (the "Stockholders Agreement"), whereby each
      stockholder agreed to vote its shares of Common Stock and take all other
      actions necessary to elect the independent directors nominated by the
      Board of Directors (the "Board") and to elect the nominee nominated to the
      Board by SkyePharma. SkyePharma does not have the right to dispose (or
      direct the disposition of) any of the 24,800,000 shares of Common Stock
      owned by the other parties to the Stockholders Agreement. Accordingly,
      SkyePharma expressly disclaims beneficial ownership of all such shares.

2     SkyePharma is currently the beneficial owner of 200,000 shares of Common
      Stock, warrants exercisable for 20,000 shares of Common Stock and
      1,500,000 shares of Series A Convertible Preferred Stock, and may acquire
      another 500,000 shares of Series A Convertible Preferred Stock pursuant to
      the Purchase Agreement. Accordingly, SkyePharma has beneficial ownership
      of 8,220,000 shares of Common Stock, assuming the exercise of the
      warrants, the purchase of the 500,000 additional shares of Series A
      Convertible Preferred Stock and the conversion of all shares of Series A
      Convertible Preferred Stock owned or to be purchased by SkyePharma into
      Common Stock at the current conversion rate of four to one.

3     Based on 37,538,179 shares of Common Stock outstanding on April 30, 2002,
      the conversion of 2,000,000 shares of Series A Convertible Preferred Stock
      into 8,000,000 shares of Common Stock and the exercise of SkyePharma's
      warrants for the purchase of 20,000 shares of Common Stock.

------------------------------------

         SkyePharma  PLC, a company  incorporated  under the laws of England and
Wales  ("SkyePharma"),  hereby amends and  supplements its Statement on Schedule
13D  filed  on  December  19,  2001 and as  amended  by  Amendment  No. 1 to the
Statement on Schedule 13D filed on January 31, 2002,  and Amendment No. 2 to the
Statement on Schedule  13D filed on March 25,  2002,  with respect to the Common
Stock,  par value $0.0001 per share (the "Common  Stock"),  of Astralis  Ltd., a
Delaware  corporation  (the  "Issuer"),  the Common Stock which is issuable upon
conversion of the Series A  Convertible  Preferred  Stock,  par value $0.001 per
share (the  "Convertible  Preferred  Stock") held by  SkyePharma  and the Common
Stock which is issuable upon exercise of the warrants held by SkyePharma.

Item 3.   Source and Amount of Funds or Other Consideration.
          --------------------------------------------------

         The source of funds for the two million shares of Convertible Preferred
Stock  convertible  into  eight  million  shares of Common  Stock to which  this
Statement relates was and will be SkyePharma's working capital. The total amount
was 20,000,000 U.S. dollars in cash of which 10,000,000 U.S. dollars was



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paid on December 10, 2001,  2,500,000 U.S. dollars was paid on January 31, 2002,
2,500,000 U.S. dollars was paid on May 1, 2002, and the remaining 5,000,000 U.S.
dollars will be paid in two equal  instalments on July 31, 2002, and January 31,
2003, in each case in accordance with the Purchase  Agreement by and between the
Issuer and SkyePharma, dated as of December 10, 2001 (the "Purchase Agreement").

Item 4. Purpose of the Transaction.
        ---------------------------

         The purpose of the  acquisition of the  Convertible  Preferred Stock by
SkyePharma was and is for investment.

         Pursuant to the terms of the  Purchase  Agreement,  on April 30,  2002,
SkyePharma purchased 250,000 newly-issued shares of Convertible  Preferred Stock
convertible into 1,000,000 shares of Common Stock. On each of July 31, 2002, and
January 31, 2003,  SkyePharma will purchase an additional  250,000  newly-issued
shares of Convertible  Preferred  Stock  convertible  into  1,000,000  shares of
Common  Stock,  for a total of 500,000  shares of  Convertible  Preferred  Stock
convertible into 2,000,000 shares of Common Stock, subject to the conditions set
forth in sections 5, 6 and 7 of the Purchase Agreement.

Item 5. Interest in Securities of the Issuer.
        -------------------------------------

         (a) The percentage interest held by SkyePharma presented below is based
on the number of shares of Common Stock  reported by the Issuer to SkyePharma as
outstanding  at April 30,  2002.  Assuming  (i) the  purchase  of an  additional
500,000 shares of Convertible Preferred Stock under the Purchase Agreement, (ii)
the  conversion  of all shares of  Convertible  Preferred  Stock owned and to be
acquired by SkyePharma into Common Stock, and (iii) the exercise of the warrants
for 20,000 shares of Common Stock,  SkyePharma  would be the beneficial owner of
8,220,000 shares of the Common Stock,  representing  approximately  18.0% of the
Common Stock issued and outstanding.

Item 7. Material to be filed as Exhibits.
        ---------------------------------

1.   Purchase Agreement, dated as of December 10, 2001, among the Issuer,
     incorporated by reference to Exhibit 2.1 of the Current Report on Form 8-K
     of the Issuer, filed by the Issuer on December 14, 2001 (File Number
     000-30997).

2.   Stockholders Agreement, dated as of December 10, 2001, among the Issuer,
     incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K
     of the Issuer, filed by the Issuer on December 14, 2001 (File Number
     000-30997).



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SIGNATURES

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: May 3, 2002

                                            SKYEPHARMA PLC



                                            By: /s/ Donald Nicholson
                                               ---------------------------------
                                                  Donald Nicholson
                                                  Chief Financial Officer