Filed pursuant to Rule 424(b)(3)
                                                      Registration No. 333-61322



                           PROSPECTUS SUPPLEMENT NO. 1
                       (to prospectus dated June 19, 2001)

                          BIOMARIN PHARMACEUTICAL INC.


                        5,621,960 Shares of Common Stock
                                par value $.001



                         ------------------------------



The prospectus of BioMarin  Pharmaceutical  Inc. dated June 19, 2001 relating to
the  sale of  BioMarin's  common  stock  from  time to time by  certain  selling
stockholders  is  hereby  supplemented  as  set  forth  below.  This  prospectus
supplement is not complete without,  and may not be delivered or utilized except
in  connection  with,  the  prospectus  dated  June 19,  2001.  This  prospectus
supplement is  incorporated  by reference into the  prospectus.  You should read
this prospectus supplement and the accompanying  prospectus carefully before you
invest.  Both documents contain information you should consider carefully before
making your investment decision.

The following table of selling stockholders reflects changes due to the transfer
by Caduceus Capital Trust,  Caduceus Capital II, LP, PW Eucalyptus Fund,  L.L.C.
and PW Eucalyptus Fund, Ltd. of warrants to purchase, in the aggregate,  159,000
shares  of  BioMarin  common  stock.  The  registration  statement  of which the
prospectus  was a part  registered  the  shares of common  stock  issuable  upon
exercise of these warrants.  The following  table lists the selling  stockholder
not previously  identified in the prospectus,  the aggregate number of shares of
common stock beneficially  owned by such selling  stockholder as of September 1,
2002,  and the  aggregate  number of shares of  common  stock  that the  selling
stockholder  may  offer  and  sell  pursuant  to  the  prospectus.  The  selling
stockholder  named  below  will  not own 1% or more of our  common  stock  after
completion of this offering.


                                                                         


                                                           Number of Shares
                                                           Beneficially        Number of
                                                           Owned Prior to      Shares Offered
     Name                                                  Offering            Hereby
     ----                                                  ----------------    ------------
     Highbridge International LLC (1).....................          159,000         159,000




(1)      Highbridge Capital Management, as managing member of Highbridge
         International LLC, has sole voting and investment control over these
         securities.


               The date of this Prospectus Supplement is September 13, 2002