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                       Securities and Exchange Commission
                              Washington, DC 20549

                                    Form 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



       Date of Report (Date of earliest event reported) November 17, 2004


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


            Delaware                    0-22319               16-1476509
(State or Other Jurisdiction of (Commission File Number)    (IRS Employer
         Incorporation)                                   Identification No.)


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  46 Prince Street, Rochester, New York                    14607
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 (Address of Principal Executive Offices)                (Zip Code)
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Registrant's telephone number, including area code:  (585) 242-7200

          (Former Name or Former Address, if Changed Since Last Report)

         Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[_]  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

[_]  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

[_]  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

[_]  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))


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ITEM 5.02 Departure of Directors or Principal  Officers;  Election of Directors;
     Appointment of Principal Officers.

     On November 17, 2004,  the Registrant  elected Edward B. Berger,  Robert M.
Kaufman and Donald R. Ryan to serve as  directors on the  Registrant's  Board of
Directors.


     Edward B. Berger,  75 (new independent  director).  Mr. Berger is currently
     Chairman and Chief Executive Officer of Equity  Acquisitions  Incorporated,
     Chairman of the Board of Directors of Southwest Business Systems,  Director
     and Chairman of the Audit  Committee of CardSystems  Solutions and Director
     of Compass Bank of Tucson, AZ. Mr. Berger has been admitted to practice law
     by the U.S. Supreme Court, New York Bar, Arizona Bar,  District of Columbia
     Bar, U.S. District Court-Arizona and the U.S. Court of Appeals 9th Circuit.
     Mr. Berger is currently an Adjunct  Professor in Political Science at Prima
     Community  College and is the Chairman of the MBA  Advisory  Council at the
     University of Arizona.  Mr. Berger  received a Juris Doctor in Law from New
     York Law  School and a Masters  Degree in  Education  as well as a B.A.  in
     History and English from the University of Arizona.


     Robert M. Kaufman, 55 (new independent director).  Mr. Kaufman is currently
     President and Chief  Executive  Officer of Oakley  Investments and Director
     and Chairman of the Audit Committee of Berkshire  Income Realty.  From June
     1996 through  November  2002, Mr.  Kaufman was Chief  Executive  Officer of
     MedEView, Inc. and Chief Executive Officer of CareMatrix Corporation. Prior
     to 1999, Mr Kaufman spent 24 years at  PriceWaterhouseCoopers,  the last 15
     years as a Partner in the firm. Mr. Kaufman  received a Masters in Business
     Administration  from Cornell  University  and a Bachelor of Arts from Colby
     College.


     Donald R.  Ryan,  56 (new  independent  director).  Mr.  Ryan is  currently
     President and Chief  Executive  Officer of CareCore  National,  LLC.  Until
     August 2000, Mr. Ryan was President of Practice Management Associates, Inc.
     Mr.  Ryan  received a Masters  Degree in Hospital  Administration  from St.
     Louis University and a Bachelors of Arts Degree in Political Science with a
     minor in Economics from Providence College.

     In  addition,   on  November  17,  2004,  the  Registrant  appointed  Roger
Chaufournier, the Registrant's existing Chief Executive Officer, to the position
of Chairman of the Board and  Christine  St. Andre,  the  Registrant's  existing
Chief Operating Officer, to the position of President. Mr. Chaufournier will now
serve as both Chief  Executive  Officer  and  Chairman  of the Board and Ms. St.
Andre will now serve as both President and Chief Operating Officer.





                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                              PATIENT INFOSYSTEMS, INC.

Date:  November 19, 2004               By:    /s/ Kent A. Tapper
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                                              Kent A. Tapper
                                              Sr. Vice President
                                              principal accounting officer