As filed with the Securities and Exchange Commission on October 8, 2004.
                                              Registration Statement 333-_______
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 ______________

                                    FORM S-8
                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933
                                 ______________

                            PATIENT INFOSYSTEMS, INC.
             (Exact name of registrant as specified in its charter)

         Delaware                                       16-1476509
(State or other jurisdiction                (I.R.S. Employer Identification No.)
 of incorporation or organization)

46 Prince Street, Rochester, New York                     14607
(Address of principal executive offices)                (Zip Code)

                   PATIENT INFOSYSTEMS, INC. STOCK OPTION PLAN
                            (Full title of the plan)

                          Mr. Roger Louis Chaufournier
                      President and Chief Executive Officer
                                46 Prince Street
                            Rochester, New York 14607
                     (Name and address of agent for service)

                                 (585) 242-7200
          (Telephone number, including area code, of agent for service)

                                    Copy to:
                             Jeffrey A. Baumel, Esq.
                            McCarter & English, LLP.
                               Four Gateway Center
                                100 Mulberry St.
                            Newark, New Jersey 07102
                                 (973) 639-5904

                         Calculation of Registration Fee



------------------------------------------ ---------------- -------------------- ----------------- -------------------
                                                                Proposed            Proposed
                                               Amount        Maximum Offering        Maximum           Amount of
           Title of Securities                  To Be              Price            Aggregate         Registration
            to be Registered                Registered(1)      Per Share(2)          Offering            Fee(2)
                                                                                     Price(2)
------------------------------------------ ---------------- -------------------- ----------------- -------------------
                                                                                           
Common Stock,  $.01 par value per share       3,410,000            $1.84            $6,274,400            $795
------------------------------------------ ---------------- -------------------- ----------------- -------------------


(1)  Pursuant to Rule 416(c) under the Securities Act of 1933, as amended,  this
     registration  statement  also  covers  additional  shares of  Common  Stock
     pursuant to the anti-dilution provisions of the Plan.

(2)  Estimated  in  accordance  with Rule  457(h)(1)  solely for the purposes of
     calculating the registration  fee, based on the average high and low prices
     per share of the Registrant's  Common Stock as reported on the OTC Bulletin
     Board on October 7, 2004.



                                EXPLANATORY NOTE

     This  Registration  Statement  is being filed in  accordance  with  General
Instruction  E of Form S-8.  Under the  Registration  Statement on Form S-8 (No.
333-36184),  140,000  shares of common stock  (1,680,000  shares  before  giving
effect to the 1 for 12 reverse split which became effective on January 9, 2004),
par value $0.01 per share ("Common Stock"),  of Patient  Infosystems,  Inc. (the
"Registrant") were registered for issuance under the Patient  Infosystems,  Inc.
Stock Option Plan (the "Plan").  In November 2003, the Board of Directors of the
Registrant  approved an amendment of the Plan to increase the maximum  number of
shares of Common  Stock  that may be issued  pursuant  to the Plan to  3,500,000
post-split   shares  of  Common  Stock.  Such  amendment  was  approved  at  the
Registrant's  special meeting of shareholders on December 31, 2003. In addition,
in February  2004,  the  Registrant  agreed to register  50,000 shares of Common
Stock  issuable to a consultant  of the  Registrant  upon exercise of a warrant.
This  Registration  Statement  covers the additional  3,360,000 shares of Common
Stock that may be issued under the Plan in accordance  with the amendment to the
Plan  described  above and the 50,000  shares of Common  Stock  issuable  to the
consultant upon exercise of the warrant.

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.  Incorporation of Documents by Reference.

     The  following  documents  have  been  filed  by the  Registrant  with  the
Securities  and Exchange  Commission  (the  "Commission")  and are  incorporated
herein by reference (Commission File No. 000-22319):

(a)  Annual  Report on Form 10-KSB for the fiscal year ended  December 31, 2003,
     filed on March 30, 2004, as amended by the Form 10-KSB/A filed on April 29,
     2004;

(b)  Quarterly Report on Form 10-QSB for the quarter ended March 31, 2004, filed
     on May 17, 2004;

(c)  Quarterly  Report on Form 10-QSB for the quarter ended June 30, 2004, filed
     on August 16, 2004;

(d)  Current Report on Form 8-K filed on January 9, 2004;

(e)  Current  Report on Form 8-K filed on January  15,  2004,  as amended by the
     Current Report on Form 8-K/A filed on March 15, 2004;

(f)  Current Report on Form 8-K filed on April 28, 2004;

(g)  Current Report on Form 8-K filed on September 1, 2004;

(h)  Current  Report on Form 8-K filed on September 24,  2004, as amended by the
     Current Report on Form 8-K/A filed on October 7, 2004; and

(i)  The description of the  Registrant's  common stock contained in its Current
     Report on Form 8-K filed on October 7, 2004.


     Information  in Current  Reports on Form 8-K  furnished  under Item 2.02 or
Item 7.01 of Form 8-K (or under Item 9 or Item 12 prior to August  23,  2004) is
not incorporated herein by reference.

     All  documents  filed  after  the date  hereof by the  Registrant  with the
Commission  (other than Current  Reports on Form 8-K furnished  pursuant to Item
2.02 or Item 7.01 of Form 8-K, unless otherwise  indicated  therein) pursuant to
Sections 13(a),  13(c), 14 and 15(d) of the Securities  Exchange Act of 1934, as
amended  (the  "Exchange  Act"),  and prior to the  filing  of a  post-effective
amendment which  indicates that all securities  offered hereby have been sold or
which  deregisters all securities then remaining  unsold,  shall be deemed to be
incorporated by reference in this  Registration  Statement and to be part hereof
from their respective  dates of filing;  provided,  however,  that the documents
enumerated  above or subsequently  filed by the Registrant  pursuant to Sections
13(a),  13(c),  14 and 15(d) of the  Exchange  Act in each year during which the
offering made hereby is in effect prior to the filing with the Commission of the
Registrant's  Annual  Report on Form  10-KSB  covering  such  year  shall not be
incorporated  by reference  herein or be a part hereof from and after the filing
of such Annual Report on Form 10-KSB.

     Any  statement  contained in a document  incorporated  by reference  herein
shall be deemed to be modified or superseded  for purposes of this  Registration
Statement  to the  extent  that a  statement  contained  herein  or in any other
subsequently  filed  document  which also is  incorporated  by reference  herein
modified  or  superseded  such  statement.  Any such  statement  so  modified or
superseded  shall  not be  deemed,  except  as so  modified  or  superseded,  to
constitute a part of this Registration Statement.

Item 8.  Exhibits.

     The Exhibits  required to be filed as part of this  Registration  Statement
are listed in the attached Exhibit Index.



                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of  Rochester,  State of New  York,  on this 8th day of
October 2004.


                                      PATIENT INFOSYSTEMS, INC.


                                      By:  /s/Roger Louis Chaufournier
                                           Roger Louis Chaufournier
                                           President and Chief Executive Officer

     KNOW ALL MEN BY THESE  PRESENTS,  each of the  undersigned  constitutes and
appoints  Roger  Louis  Chaufournier  and Kent  Tapper,  and  each of  them,  as
attorneys-in-fact   and   agents,   with   full   power  of   substitution   and
resubstitution,  for and in the name, place and stead of the undersigned, in any
and all  capacities,  to sign any and all amendments  (including  post-effective
amendments) to this  registration  statement or any  registration  statement for
this  offering that is to be effective  upon the filing  pursuant to Rule 462(b)
under the Securities Act of 1933, as amended, and all post-effective  amendments
thereto, and to file the same, with all exhibits thereto and all other documents
in connection therewith,  with the Securities and Exchange Commission,  granting
unto said  attorneys-in-fact  and  agents  full  power and  authority  to do and
perform each and every act and thing  requisite  and necessary to be done in and
about the  premises,  as fully to all  intents and  purposes as the  undersigned
might or could do in person,  hereby  ratifying and  confirming all that each of
said attorney-in-fact or substitute or substitutes,  may lawfully do or cause to
be done by virtue hereof.

     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  registration  statement  has been signed by the  following  persons in the
capacities and on the dates indicated.

Signature                Title                                  Date
/s/Roger L Chaufournier  Director, President and Chief          October 8, 2004
Roger Louis Chaufournier Executive Officer
                         (Principal Executive Officer)
/s/Kent A. Tapper        Vice President Financial Planning      October 8, 2004
Kent A. Tapper           (Principal Financial and Accounting
                         Officer)
/s/Derace L. Schaffer    Chairman of the Board                  October 8, 2004
Derace L. Schaffer, M.D.

/s/John Pappajohn        Director                               October 8, 2004
John Pappajohn


                                  EXHIBIT INDEX


No.                   Description                   Method of Filing

4.1  Patient Infosystems, Inc.          Incorporated by reference to Exhibit 4.1
     Stock Option Plan,as amended       of the Registrant's Annual Report on
                                        Form 10-KSB filed March 30, 2004.

4.2  Certificate of Incorporation,      Incorporated by reference to Exhibit 3.1
     as amended                         of the Registrant's Registration
                                        Statement on Form S-1 (File No.
                                        333-07643) filed on July 3, 1996 and the
                                        Registrant's Annual Report on Form
                                        10-KSB filed on March 30, 2004.

4.3  By-Laws                            Incorporated by reference to Exhibit 3.3
                                        to the Registrant's Registration
                                        Statement on Form S-1 (File No.
                                        333-07643) filed on July 3, 1996.

5.1  Opinion of McCarter & English, LLP Filed with this Registration Statement.

23.1 Consent of Deloitte & Touche, LLP  Filed with this Registration Statement.

23.2 Consent of McGladrey & Pullen, LLP Filed with this Registration Statement.

23.3 Consent of BDO Seidman, LLP        Filed with this Registration Statement.

23.4 Consent of McCarter & English, LLP Included in Exhibit 5.1.

24.1 Powers of Attorney                 Included on the signature page of
                                        this Registration Statement