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                       Securities and Exchange Commission
                              Washington, DC 20549

                                   Form 8-K/A

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



        Date of Report (Date of earliest event reported) September 24, 2004


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


            Delaware                    0-22319               16-1476509
(State or Other Jurisdiction of (Commission File Number)     (IRS Employer
         Incorporation)                                    Identification No.)


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 46 Prince Street, Rochester, New York              14607
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(Address of Principal Executive Offices)          (Zip Code)
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Registrant's telephone number, including area code:  (585) 242-7200

          (Former Name or Former Address, if Changed Since Last Report)

         Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[_]  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

[_]  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

[_]  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

[_]  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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ITEM 2.01 Completion of Acquisition or Disposition of Assets.

     On  September  22, 2004,  the  Registrant  acquired all of the  outstanding
capital  stock of CBCA  Care  Management,  Inc.  pursuant  to the  Agreement  of
Purchase  and Sale dated as of August 26,  2004 (the  "Agreement")  between  the
Registrant,  CBCA Care Management,  Inc and CBCA, Inc. CBCA Care Management is a
full service care management company, which provides services to health plans to
lower the cost of patients'  encounters with the healthcare delivery system. The
purchase  price  for the  acquisition  was  $7.1  million  in cash,  subject  to
adjustment.  The  acquisition was funded through an increase of $4 million to an
existing  line of credit from Wells Fargo Bank,  N.A. The entire $7 million line
of credit  was  extended  an  additional  12 months to July 2006.  The  variable
interest  rate is currently  3.75%.  The line of credit was  guaranteed  by John
Pappajohn and Derace Schaffer,  members of the board of directors,  who received
warrants  to  purchase  700,000  and  100,000  shares  of  common  stock  of the
Registrant,  respectively,  for  $1.86  per  share  in  consideration  of  their
agreement  to  provide  the  guarantees  for the  additional  $4  million.  John
Pappajohn and Derace  Schaffer also  received  warrants to purchase  116,667 and
83,333  shares of common stock of the  Registrant,  respectively,  for $1.86 per
share in  consideration  of their  agreement to provide the  guarantees  for the
extended term of the line of credit.

ITEM 9.01  Financial Statements and Exhibits

(c)  Exhibits

     The required historical financial statements of CBCA Care Management,  Inc.
and related pro forma financial information will be filed by amendment.

     The Press  Release  issued by the  Registrant  on  September  24,  2004 was
previously  filed  with the  Registrant's  Current  Report  on Form 8-K filed on
September 24, 2004. The information contained herein supplements and updates the
information  contained  in the  Registrant's  Current  Report  on 8-K  filed  on
September 24, 2004.





                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                             PATIENT INFOSYSTEMS, INC.

Date:  October 7, 2004                By:    /s/Kent A. Tapper
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                                             Kent A. Tapper
                                             Sr. Vice President
                                             principal accounting officer