Securities and Exchange Commission
                              Washington, DC 20549

                                    Form 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest event reported)  December 31, 2003

                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


             Delaware               0-22319                    16-1476509
(State or Other Jurisdiction  (Commission File Number)       (IRS Employer
 of Incorporation)                                          Identification No.)

46 Prince Street, Rochester, New York                        14607
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(Address of Principal Executive Offices)                     (Zip Code)

Registrant's telephone number, including area code  (585) 242-7200
                                                    --------------

          (Former Name or Former Address, if Changed Since Last Report)



ITEM 2.  ACQUISITION OR DISPOSITION OF ASSETS.

     On December 31, 2003, Patient Infosystems,  Inc. acquired substantially all
of the assets and  substantially  all of the liabilities of American  CareSource
Corporation  (ACS), a Dallas based company that operates as a national ancillary
benefits  management company.  The acquired assets include,  among other things,
accounts  and notes  receivable,  intellectual  property,  customer and supplier
contracts and tangible personal property. In consideration,  Patient Infosystems
issued 1,100,000 shares of its common stock (on a post-split  basis) to ACS. The
terms of the acquisition,  including the consideration,  were determined through
arm's length  negotiations  between  Patient  Infosystems and ACS. In connection
with this  transaction,  Patient  Infosystems  loaned  $3.4  million  to ACS for
working capital and repayment of  indebtedness.  ACS will continue to operate in
the  ancillary  benefits  management  industry  under its name as a wholly owned
subsidiary of Patient Infosystems.

ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

(a)  The required historical  financial  statements of ACS and related pro forma
     financial information to be filed by amendment.



                                   SIGNATURES
         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                  PATIENT INFOSYSTEMS, INC.

Date:  January 15, 2003                           By: /s/ Roger L. Chaufourner
                                                      ------------------------
                                                      Roger L. Chaufournier
                                                      Chief Executive Officer