OMB APPROVAL OMB Number: 3235-0578 Expires: April 30, 2013 Estimated average burden hours per response..... 5.6 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-Q QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY Investment Company Act file number 811-21409 Pioneer Municipal High Income Advantage Trust (Exact name of registrant as specified in charter) 60 State Street, Boston, MA 02109 (Address of principal executive offices) (ZIP code) Terrence J. Cullen, Pioneer Investment Management, Inc., 60 State Street, Boston, MA 02109 (Name and address of agent for service) Registrant's telephone number, including area code: (617) 742-7825 Date of fiscal year end: March 31 Date of reporting period: December 31, 2010 Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after close of the first and third fiscal quarters, pursuant to Rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles. A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss. 3507. ITEM 1. Schedule of Investments. Pioneer Municipal High Income Advantage Trust SCHEDULE OF INVESTMENTS 12/31/10 (unaudited) Principal Amount Value TAX-EXEMPT OBLIGATIONS - 146.8% of Net Assets Alabama - 0.7% 2,500,000 Huntsville-Redstone Village Special Care Facil 1,849,375 Arizona - 3.4% 5,000,000 Casa Grande Industrial Development Authority H 4,716,850 1,512,000 Pima County Industrial Development Authority, 1,414,400 2,640,000 Pima County Industrial Development Authority, 2,376,370 1,000,000 San Luis Facility Development Corp., 7.25%, 5/ 954,500 9,462,120 California - 9.7% 3,140,000 California State University Revenue, RIB, 12.6 2,853,066 2,425,000 California State Various Purpose, 5.75%, 4/1/3 2,445,346 8,575,000 California State Various Purpose, RIB, 12.641% 6,469,838 803,175 California Statewide Communities Development A 63,250 2,680,000 Golden State Tobacco Securitization Corp., 6.7 3,023,388 2,500,000 San Jose California Airport Revenue, 5.0%, 3/1 2,275,950 10,500,000University of California, RIB, 12.988%, 5/15/3 9,586,920 26,717,758 Colorado - 1.4% 2,850,000 Denver Health & Hospital Authority Healthcare 2,994,410 1,000,000 Kremmling Memorial Hospital District, 7.125%, 950,780 3,945,190 Connecticut - 2.6% 7,750,000 Connecticut State Development Authority Revenu 7,276,785 District of Columbia - 3.4% 2,700,000 District of Columbia Tobacco Settlement Financ 2,662,173 6,825,000 District of Columbia Tobacco Settlement Financ 6,637,654 9,299,827 Florida - 4.2% 1,000,000 Florida Development Finance Corp., 6.0%, 9/15/ 853,590 4,500,000 Hillsborough County Industrial Development Aut 4,573,080 1,980,000 Hillsborough County Industrial Development Aut 1,819,778 1,000,000 Hillsborough County Industrial Development Aut 1,356,690 500,000 Miami Beach Health Facilities Authority, 5.375 422,325 2,500,000 Miami-Dade County Florida Aviation Revenue, 5. 2,425,150 11,450,613 Georgia - 4.4% 5,210,000 Atlanta Georgia Water and Wastewater Revenue, 4,214,109 1,000,000 Clayton County Development Authority Special F 1,085,800 900,000 DeKalb County Georgia Hospital Authority Reven 888,668 750,000 DeKalb County Georgia Hospital Authority Reven 730,433 1,065,000 Effingham County Industrial Development Author 1,003,124 3,360,000 Fulton County Residential Care Facilities, 7.0 2,541,605 1,650,000 Savannah Georgia Economic Development Authorit 1,598,751 12,062,490 Guam - 2.2% 1,000,000 Guam Government Department Education Certifica 971,650 4,400,000 Northern Mariana Islands, 6.75%, 10/1/33 5,081,868 6,053,518 Idaho - 1.8% 2,000,000 Power County Industrial Development Corp., 6.4 1,970,120 3,000,000 Power County Pollution Control Revenue, 5.625% 2,994,600 4,964,720 Illinois - 8.6% 3,000,000 Centerpoint Intermodal Center, 7.5%, 6/15/23 ( 2,999,970 2,000,000 City of Chicago Illinois, 5.5%, 12/1/30 1,625,140 1,450,000 Illinois Finance Authority Revenue, 5.5%, 4/1/ 1,346,195 2,000,000 Illinois Finance Authority Revenue, 6.0%, 8/15 2,049,180 1,000,000 Illinois Finance Authority Revenue, 6.0%, 11/1 748,850 2,000,000 Illinois Finance Authority Revenue, 6.0%, 8/15 2,102,820 2,500,000 Illinois Finance Authority Revenue, 6.125%, 11 2,203,275 6,000,000 Illinois Finance Authority Revenue, 8.25%, 5/1 5,958,360 2,500,000 Illinois Finance Authority Revenue, 8.25%, 2/1 2,471,350 1,500,000 Illinois Health Facilities Authority Revenue, 552,600 2,440,000 Southwestern Illinois Development Authority Re 1,678,793 23,736,533 Indiana - 6.0% 250,000 East Chicago Indiana Exempt Facilities Revenue 239,295 10,000,000Indiana State Development Finance Authority Re10,083,200 5,000,000 Jasper County Industrial Economic Development 4,502,850 1,900,000 Vincennes Industrial Economic Development Reve 1,631,549 16,456,894 Kansas - 0.3% 1,000,000 Kansas Development Finance Authority, 5.0%, 5/ 901,050 Kentucky - 1.4% 4,400,000 Kentucky Economic Development Finance Authorit 3,774,496 Louisiana - 5.1% 2,500,000 Louisiana Local Government Environmental Facil 2,512,425 6,000,000 Louisiana Public Facilities Authority Revenue, 5,070,120 750,000 Opelousas Louisiana General Hospital Authority 751,425 5,915,000 Tobacco Settlement Financing Corp., 5.875%, 5/ 5,644,093 13,978,063 Maryland - 1.5% 460,000 Maryland Health & Higher Educational Facilitie 366,855 1,250,000 Maryland Health & Higher Educational Facilitie 860,038 1,250,000 Maryland Health & Higher Educational Facilitie 1,096,050 2,000,000 Maryland Health & Higher Educational Facilitie 1,937,140 4,260,083 Massachusetts - 8.4% 755,000 Massachusetts Development Finance Agency, 5.25 713,090 5,000,000 Massachusetts Development Finance Agency, 5.75 5,050,750 1,930,000 Massachusetts Development Finance Agency, 7.1% 1,735,070 2,195,000 Massachusetts Health & Educational Facilities 1,903,592 1,000,000 Massachusetts Health & Educational Facilities 1,093,039 3,420,000 Massachusetts Health & Educational Facilities 2,868,559 10,760,000Massachusetts Housing Finance Agency, 5.35%, 1 9,727,255 23,091,355 Michigan - 3.7% 1,500,000 Delta County Michigan Economic Development Cor 1,606,995 500,001 Flint Michigan Hospital Building Authority Rev 483,650 3,000,000 Macomb County Hospital Finance Authority Reven 3,407,520 735,000 Michigan Public Educational Facilities Authori 644,419 4,130,000 Michigan State Hospital Finance Authority Reve 3,991,232 3,405,000 Wayne Charter Escrow, 0.0%, 12/1/15 34 10,133,850 Missouri - 1.5% 1,500,000 St. Louis Industrial Development Authority Rev 780,660 6,640,000 St. Louis Industrial Development Authority Rev 3,451,472 4,232,132 Montana - 0.6% 2,445,000 Hardin Increment Industrial Infrastructure Dev 1,391,181 1,000,000 Two Rivers Authority, Inc., Project Revenue, 7 150,040 1,541,221 Nevada - 2.2% 1,500,000 Henderson Nevada Health Care Facilities Revenu 1,526,400 1,600,000 Nevada State Department of Business & Industry 15 1,000,000 Nevada State Department of Business & Industry 10 1,320,000 Nevada State Department of Business & Industry 13 5,000,000 Reno Nevada Hospital Revenue, 5.25%, 6/1/41 4,402,550 5,928,988 New Hampshire - 0.4% 1,125,000 New Hampshire Health & Educational Facilities 1,027,046 New Jersey - 12.5% 2,500,000 Burlington County New Jersey Bridge Commission 2,046,800 13,000,000New Jersey Economic Development Authority Reve12,105,080 3,500,000 New Jersey State Turnpike Authority, RIB, 13.4 3,982,090 15,375,000New Jersey Transportation Trust Fund Authority 5,614,950 1,000,000 Tobacco Settlement Financing Corp., 6.25%, 6/1 1,123,170 3,250,000 Tobacco Settlement Financing Corp., 6.75%, 6/1 3,688,945 5,000,000 Tobacco Settlement Financing Corp., 7.0%, 6/1/ 5,703,750 34,264,785 New York - 8.1% 1,800,000 Dutchess County Industrial Development Agency, 1,742,652 3,000,000 Nassau County New York Industrial Development 2,750,760 5,000,000 New York City Industrial Development Agency, 5 3,842,450 3,950,000 New York City Industrial Development Agency, 7 3,976,663 2,000,000 New York State Dormitory Authority Revenue, 6. 1,937,900 5,000,000 New York State Environmental Facilities Corp., 4,926,900 3,000,000 Ulster County New York Industrial Development 2,634,510 500,000 Ulster County New York Industrial Development 394,865 22,206,700 North Carolina - 1.7% 5,010,000 Charlotte North Carolina Special Facilities Re 4,808,748 Ohio - 2.9% 1,635,000 Belmont County Health System Revenue, 5.7%, 1/ 1,193,500 1,000,000 Belmont County Health System Revenue, 5.8%, 1/ 730,460 5,000,000 Buckeye Tobacco Settlement Financing Authority 3,587,550 3,000,000 Cleveland Airport Special Revenue, 5.375%, 9/1 2,508,330 8,019,840 Oklahoma - 2.9% 1,295,000 Jackson County Memorial Hospital Authority Rev 1,295,376 2,220,000 Tulsa Municipal Airport Trust Revenue, 6.25%, 2,103,494 1,500,000 Tulsa Municipal Airport Trust Revenue, 7.35%, 1,493,910 3,000,000 Tulsa Municipal Airport Trust Revenue, 7.75%, 3,064,380 7,957,160 Oregon - 1.0% 3,000,000 Oregon State Facilities Authority Revenue, 5.2 2,775,120 Pennsylvania - 7.3% 3,600,000 Columbia County Hospital Authority Revenue, 5. 3,088,764 830,000 Hazleton Health Services Authority Hospital Re 830,407 1,430,000 Pennsylvania Economic Development Financing Au 1,239,367 2,330,000 Pennsylvania Economic Development Financing Au 2,307,749 5,000,000 Pennsylvania Economic Development Financing Au 4,235,800 5,000,000 Philadelphia Hospitals & Higher Education Faci 4,118,400 2,005,000 Scranton-Lackawanna Health & Welfare Authority 1,987,436 2,245,000 Scranton-Lackawanna Health & Welfare Authority 2,188,269 19,996,192 Rhode Island - 3.1% 1,385,000 Central Falls Rhode Island Detention Facilitie 1,138,525 8,285,000 Tobacco Settlement Financing Corp., 6.25%, 6/1 7,431,810 8,570,335 South Carolina - 5.3% 1,500,000 Connector 2000 Association, Inc., Toll Road Re 221,250 7,140,000 South Carolina Jobs Economic Development Autho 8,006,439 860,000 South Carolina Jobs Economic Development Autho 974,681 4,400,000 Tobacco Settlement Revenue Management, 6.375%, 5,365,800 14,568,170 Tennessee - 3.8% 1,000,000 Johnson City Health & Educational Facilities B 1,105,860 7,000,000 Knox County Health Educational & Housing Facil 7,353,920 2,400,000 Sullivan County Health Educational and Housing 2,040,816 10,500,596 Texas - 18.1% 4,095,000 Dallas-Fort Worth International Airport Facili 4,255,196 2,827,398 Gulf Coast Industrial Development Authority, 7 222,658 10,000,000Houston Texas Airport System Special Facilitie 9,850,700 845,000 IAH Public Facility Corp., Project Revenue Bon 786,509 1,000,000 IAH Public Facility Corp., Project Revenue Bon 859,760 1,350,000 IAH Public Facility Corp., Project Revenue Bon 1,119,110 2,750,000 Lower Colorado River Authority, 5.0%, 5/15/31 2,691,370 845,000 Lubbock Health Facilities Development Corp., 6 798,567 2,000,000 Lubbock Health Facilities Development Corp., 6 1,798,820 7,750,000 Matagorda County Navigation District Number 1 7,319,565 9,750,000 North Texas Tollway Authority Revenue, 5.75%, 9,351,128 1,711,000 Panhandle Regional Housing Finance Corp. Multi 1,759,267 1,000,000 Richardson Hospital Authority Revenue, 6.0%, 1 897,390 1,000,000 Tarrant County Cultural Education Facilities F 1,004,100 1,500,000 Tarrant County Cultural Education Facilities F 1,513,335 1,000,000 Texas Midwest Public Facility Corp. Revenue, 9 984,270 4,700,000 Tomball Hospital Authority, 6.0%, 7/1/25 4,702,961 49,914,706 Utah - 0.4% 1,600,000 Spanish Fork Charter School Revenue, 5.7%, 11/ 1,192,000 Virginia - 0.8% 2,000,000 Washington County Industrial Development Autho 2,209,140 Washington - 3.9% 1,155,000 Tobacco Settlement Authority Revenue, 6.5%, 6/ 1,168,179 2,000,000 Washington State Health Care Facilities Author 1,982,960 2,500,000 Washington State Health Care Facilities Author 2,208,125 2,000,000 Washington State Health Care Facilities Author 1,999,820 5,000,000 Washington State Housing Finance Commission No 3,469,650 10,828,734 Wisconsin - 1.4% 2,900,000 Aztalan Wisconsin Exempt Facilities Revenue, 7 362,500 1,000,000 Wisconsin State Health & Educational Facilitie 970,530 1,000,000 Wisconsin State Health & Educational Facilitie 928,930 1,500,000 Wisconsin State Health & Educational Facilitie 1,577,145 3,839,105 TOTAL TAX-EXEMPT OBLIGATIONS (Cost $411,041,321) 403,795,438 MUNICIPAL COLLATERALIZED DEBT OBLIGATION - 2.9% of Net Assets 13,000,000Non-Profit Preferred Funding Trust I, Series E 7,849,530 TOTAL MUNICIPAL COLLATERALIZED DEBT OBLIGATION (Cost $13,000,000) 7,849,530 Shares COMMON STOCK - 0.5% of Net Assets 110,442 Delta Airlines, Inc. 1,391,569 TOTAL COMMON STOCK (Cost $3,210,349) 1,391,569 TOTAL INVESTMENTS IN SECURITIES - 150.1% (Cost $427,251,670) (i)(j) 413,036,537 OTHER ASSETS AND LIABILITIES 4.4% 12,086,014 PREFERRED SHARES AT REDEMPTION VALUE, INCLUDIN-150,010,569 NET ASSETS APPLICABLE TO COMMON SHAREOWNERS - 275,111,982 (144A) Security is exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold normally to qualified institutional buyers in a transaction exempt from registration. At December 31, 2010, the value of these securities amounted to $29,560,603, or 10.7% of total net assets applicable to common shareowners. RIB Residual Interest Bonds. NR Security not rated by S&P or Moody's. + Prerefunded bonds have been collateralized by U.S. Treasury or U.S. Government Agency securities which are held in escrow to pay interest and principal on the tax exempt issue and to retire the bonds in full at the earliest refunding date. (a) The interest rate is subject to change periodically and inversely based upon prevailing market rates. The rate shown is the coupon rate at December 31, 2010. (b) Security is in default and is non-income producing. (c) The interest rate is subject to change periodically. The interest rate shown is the rate at December 31, 2010. (d) Non-income producing. (e) Security is fair valued (See Note A). (f) Debt obligation initially issued at one coupon which converts to a higher coupon at a specific date. The rate shown is the coupon rate at December 31, 2010. (g) Indicates a security that has been deemed illiquid. The aggregate cost of illiquid securities is $16,342,295. The aggregate value is $8,212,043, or 3.0% of the total net assets applied to common shareowners. (h) Escrow to maturity. (i) The concentration of investments by type of obligation/market sector is as follows: Insured FSA 5.9 % AMBAC 1.8 MBIA 1.4 AGM 0.7 Q-SBLF 0.2 Health Revenue 35.5 Tobacco Revenue 11.1 Development Revenue 9.7 Airport Revenue 8.7 Other Revenue 7.4 Pollution Control Revenue 6.5 Housing Revenue 2.8 Facilities Revenue 2.5 Transportation Revenue 2.3 Education Revenue 1.2 Water Revenue 1.2 Power Revenue 1.1 Utilities Revenue* 0.0 100.0% Amount is less than 0.1% (j) At December 31, 2010, the net unrealized gain on investments based on cost for federal income tax purposes of $421,164,839 was as follows: Aggregate gross unrealized gain for all investments in which there is an excess of value over tax cost $ 31,254,889 Aggregate gross unrealized loss for all investments in which there is an excess of tax cost over value (39,383,191) Net unrealized gain $ (8,128,302) For financial reporting purposes net unrealized loss on investments was $14,215,133 and cost of investments aggregated $427,251,670. Purchases and sales of securities (excluding temporary cash investments) for the nine months ended December 31, 2010 aggregated $35,093,146 and $30,073,880, respectively. Various inputs are used in determining the value of the Trust's investments. These inputs are summarized in the three broad levels listed below. Highest priority is given to Level 1 inputs and lowest priority is given to Level 3. Level 1 - quoted prices in active markets for identical securities Level 2 - other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.) Level 3 - significant unobservable inputs (including the Trust's own assumptions in determining fair value of investments) The following is a summary of the inputs used as of December 31, 2010, in valuing the Trust's Investments: The following is a summary of the inputs used as of December 31, 2010, in valuing the Fund's assets: Level 1 Level 2 Level 3 Total Tax exempt obligations $0 $403,795,404 $0 $403,795,404 Municipal collateralized 0 7,849,530 34 7,849,564 Common Stock 1,391,569 0 0 1,391,569 Total $1,391,569 $411,644,934 $34 $413,036,537 Following is a reconciliation of assets valued using significant unobservable inputs (Level 3): Tax-Exempt Obligation Michigan Balance as of 3/31/10 $0 Realized gain (loss) 0 Change in unrealized gain (loss) 0 Net purchases (sales) 34 Transfers in and out of level 3 Balance as of 12/31/10 $34 ITEM 2. CONTROLS AND PROCEDURES. (a) Disclose the conclusions of the registrant's principal executive and principal financial officers, or persons performing similar functions, regarding the effectiveness of the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Act (17 CFR 270.30a-3(c))) as of a date within 90 days of the filing date of the report that includes the disclosure required by this paragraph, based on the evaluation of these controls and procedures required by Rule 30a-3(b) under the Act (17 CFR 270.30a-3(b))) and Rule 13a-15(b) or 15d-15(b) under the Exchange Act (17 CFR 240.13a-15(b) or 240.15d-15(b)). The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report. (b) Disclose any change in the registrant's internal controls over financial reporting (as defined in Rule 30a-3(d) under the Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting. There were no significant changes in the registrant's internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 3. EXHIBITS. (a) A separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the Act (17 CFR 270.30a-2(a)). Filed herewith. SIGNATURES [See General Instruction F] Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. (Registrant) Pioneer Municipal High Income Advantage Trust By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr, President Date March 1, 2011 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr., President Date March 1, 2011 By (Signature and Title)* /s/ Mark Bradley Mark Bradley, Treasurer Date March 1, 2011 * Print the name and title of each signing officer under his or her signature.