OMB APPROVAL OMB Number: 3235-0578 Expires: April 30, 2010 Estimated average burden hours per response..... 10.5 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-Q CERTIFIED SHAREHOLDER REPORT OF REGISTERED MANAGEMENT INVESTMENT COMPANIES Investment Company Act file number 811-21409 Pioneer Municipal High Income Advantage Trust (Exact name of registrant as specified in charter) 60 State Street, Boston, MA 02109 (Address of principal executive offices) (ZIP code) Dorothy E. Bourassa, Pioneer Investment Management, Inc., 60 State Street, Boston, MA 02109 (Name and address of agent for service) Registrant's telephone number, including area code: (617) 742-7825 Date of fiscal year end: March 31 Date of reporting period: December 31, 2007 Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after close of the first and third fiscal quarters, pursuant to Rule 30b1-5under the Investment Company Act of 1940 (17 CFR 270.30b-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles. A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss. 3507. ITEM 1. Schedule of Investments. Pioneer Municipal High Income Advantage Trust SCHEDULE OF INVESTMENTS 12/31/07 (unaudited) Principal Amount ($) Value TAX-EXEMPT OBLIGATIONS - 137.8% of Net Assets Alaska - 1.3% 3,875,000(a)Alaska State Housing Finance Corp., RIB, 9.78%, $ 4,190,076 Arizona - 4.2% 5,000,000 Casa Grande Industrial Development Authority, H $ 5,324,250 3,000,000(a)Downtown Phoenix Hotel Corp., RIB, 6.253%, 7/1/ 3,054,870 1,000,000 Pima County Industrial Development Authority, 6 1,018,090 1,551,000 Pima County Industrial Development Authority, 6 1,593,621 1,000,000+ Pima County Industrial Development Authority, 7 1,209,410 2,000,000 San Luis Facility Development Corp., 7.25%, 5/1 1,911,480 $ 14,111,721 California - 7.7% 2,680,000+ Golden State Tobacco Securitization Corp., 6.75 $ 3,097,973 5,000,000 San Jose California Airport Revenue, 5.0%, 3/1/ 5,163,000 9,520,000(a)University of California, RIB, 6.601%, 5/15/38 10,525,788 9,015,000 Valley Health System Hospital Revenue, 6.875%, 6,882,051 $ 25,668,812 Colorado - 2.1% 2,850,000+ Denver Health & Hospital Authority Healthcare R $ 3,129,357 3,520,000+ Northwest Parkway Public Highway Authority, 7.1 3,969,539 $ 7,098,896 District of Columbia - 2.1% 2,700,000 District of Columbia Tobacco Settlement Financi $ 2,743,605 4,000,000 District of Columbia Tobacco Settlement Financi 4,085,800 $ 6,829,405 Florida - 5.9% 1,000,000 Greater Orlando Aviation Authority, 6.5%, 11/15 $ 942,970 4,500,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 5.5%, 10/1/23 4,565,250 1,980,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 6.75%, 7/1/29 1,983,663 500,000 Miami Beach Health Facilities Authority, 5.375% 447,995 1,500,000 Miami Beach Health Facilities Authority, 6.7%, 1,547,475 10,000,000 Miami-Dade County Aviation Revenue, 5.0%, 10/1/ 10,148,000 $ 19,635,353 Georgia - 2.1% 4,000,000(a)Atlanta Georgia Water and Wastewater Revenue, R $ 4,319,320 1,065,000 Effingham County Industrial Development Authori 1,027,746 1,650,000 Savannah Georgia Economic Development Authority 1,683,842 $ 7,030,908 Guam - 2.5% 3,000,000 Northern Mariana Islands, 5.0%, 6/1/30 $ 2,680,200 4,600,000+ Northern Mariana Islands, 6.75%, 10/1/33 5,368,660 400,000 Northern Mariana Islands, 6.75%, 10/1/33 422,504 $ 8,471,364 Idaho - 2.4% 2,000,000 Power County Industrial Development Corp., 6.45 $ 2,043,460 5,920,000 Power County Pollution Control Revenue, 5.625% 5,994,592 $ 8,038,052 Illinois - 5.8% 4,000,000 Centerpoint Intermodal Center, 8.0%, 6/15/23 (1 $ 3,870,040 1,100,000 Illinois Finance Authority Revenue, 5.5%, 5/15/ 1,001,583 1,850,000 Illinois Finance Authority Revenue, 5.75%, 5/15 1,679,393 1,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15 956,360 3,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15 2,814,270 1,645,000 Illinois Health Facilities Authority Revenue, 5 1,545,165 1,265,000 Illinois Health Facilities Authority Revenue, 6 1,265,721 2,400,000 Illinois Health Facilities Authority Revenue, 6 2,401,368 1,500,000 Illinois Health Facilities Authority Revenue, 6 1,321,095 2,700,000 Southwestern Illinois Development Authority Rev 2,576,178 $ 19,431,173 Indiana - 4.9% 10,000,000 Indiana State Development Finance Authority Rev $ 10,072,600 5,000,000 Jasper County Industrial Economic Development R 4,330,150 2,170,000 Vincennes Industrial Economic Development Reven 2,070,744 $ 16,473,494 Kentucky - 1.4% 500,000 Kentucky Economic Development Finance Authority $ 496,320 4,400,000 Kentucky Economic Development Finance Authority 4,252,292 $ 4,748,612 Louisiana - 2.9% 750,000 Opelousas Louisiana General Hospital Authority $ 774,023 9,415,000 Tobacco Settlement Financing Corp., 5.875%, 5/1 9,043,578 $ 9,817,601 Maryland - 0.5% 710,000 Maryland Health & Higher Educational Facilities $ 633,490 1,250,000 Maryland Health & Higher Educational Facilities 1,084,125 $ 1,717,615 Massachusetts - 7.3% 5,000,000 Massachusetts Bay Transportation Authority Reve $ 5,618,600 2,195,000 Massachusetts Health & Educational Facilities A 2,090,123 1,000,000+ Massachusetts Health & Educational Facilities A 1,133,030 3,520,000(a)Massachusetts State College Building Authority 3,867,389 900,000 Massachusetts State Development Finance Agency, 853,146 2,920,000 Massachusetts State Development Finance Agency, 2,878,770 4,625,000 Massachusetts State Development Finance Agency, 4,688,039 3,335,000(a)Massachusetts State Housing Finance Agency, RIB 3,342,003 $ 24,471,100 Michigan - 3.7% 1,650,000 Crescent Academy Project Full Term Certificates $ 1,445,054 1,500,000+ Delta County Michigan Economic Development Corp 1,673,625 3,000,000 Macomb County Hospital Finance Authority Revenu 2,942,940 4,130,000 Michigan State Hospital Finance Authority Reven 3,754,583 1,000,000 Michigan State Strategic Fund Solid Waste Dispo 1,009,540 1,470,000 Star International Academy Full Term Certificat 1,407,584 3,405,000 Wayne Charter County Special Airport Facilities - $ 12,233,326 Missouri - 2.9% 1,850,000 Kansas City Industrial Development Authority Re $ 1,738,852 1,500,000 St. Louis Industrial Development Authority Reve 1,484,100 6,640,000 St. Louis Industrial Development Authority Reve 6,544,318 $ 9,767,270 Montana - 0.7% 2,445,000(b)Hardin Increment Industrial Infrastructure Deve $ 1,657,808 1,000,000 Two Rivers Authority, Inc., Project Revenue, 7. 790,830 $ 2,448,638 Nevada - 1.4% 2,425,000 Clark County Industrial Development Revenue, 5. $ 2,183,810 1,600,000 Nevada State Department of Business & Industry, 1,513,152 1,000,000 Nevada State Department of Business & Industry, 937,640 70,000 Nevada State Department of Business & Industry, 64,548 $ 4,699,150 New Hampshire - 1.5% 1,000,000 New Hampshire Health & Educational Facilities A $ 896,500 1,125,000 New Hampshire Health & Educational Facilities A 1,119,758 3,000,000+ New Hampshire Higher Educational & Health Facil 3,060,000 $ 5,076,258 New Jersey - 9.4% 2,500,000 Burlington County New Jersey Bridge Commission $ 2,305,275 13,000,000 New Jersey Economic Development Authority Reven 12,151,360 2,500,000 New Jersey Health Care Facilities Financing Aut 2,424,125 2,495,000(a)New Jersey State Turnpike Authority, RIB, 9.521 3,774,062 1,000,000+ Tobacco Settlement Financing Corp., 6.25%, 6/1/ 1,137,860 3,250,000+ Tobacco Settlement Financing Corp., 6.75%, 6/1/ 3,777,735 5,000,000+ Tobacco Settlement Financing Corp., 7.0%, 6/1/4 5,870,500 $ 31,440,917 New York - 11.1% 3,000,000 Dutchess County Industrial Development Agency R $ 3,181,680 5,000,000 Nassau County New York Industrial Development A 5,018,450 1,000,000 Nassau County New York Industrial Development A 1,000,000 6,980,000 New York City Industrial Development Agency, 5. 5,812,735 2,000,000 New York City Industrial Development Agency, 5. 1,933,800 2,000,000 New York City Industrial Development Agency, 6. 2,001,500 3,950,000 New York City Industrial Development Agency, 7. 4,149,277 2,400,000 New York City Industrial Development Agency, 7. 2,405,424 5,000,000 New York State Environmental Facilities Corp., 5,148,900 4,500,000 Suffolk County New York Industrial Development 3,792,915 500,000 Ulster County New York Industrial Development A 468,475 2,000,000 Yonkers Industrial Development Agency Civic Fac 1,995,340 $ 36,908,496 North Carolina - 5.2% 11,350,000 Charlotte North Carolina Special Facilities Rev $ 10,144,743 7,140,000 Charlotte North Carolina Special Facilities Rev 7,336,921 $ 17,481,664 Ohio - 2.2% 3,800,000 Belmont County Health System Revenue, 5.7%, 1/1 $ 3,762,646 1,000,000 Belmont County Health System Revenue, 5.8%, 1/1 954,050 3,000,000 Cleveland Airport Special Revenue, 5.375%, 9/15 2,601,300 $ 7,317,996 Oklahoma - 1.7% 1,875,000 Jackson County Memorial Hospital Authority Reve $ 1,883,588 2,220,000 Tulsa Municipal Airport Transportation Revenue, 2,149,204 1,500,000 Tulsa Municipal Airport Transportation Revenue, 1,500,840 $ 5,533,632 Pennsylvania - 8.8% 3,000,000+ Allegheny County Hospital Development Authority $ 3,539,280 500,000 + Allegheny County Hospital Development Authority 589,880 1,000,000 Clarion County Hospital Authority Revenue, 5.62 1,001,250 3,600,000 Columbia County Hospital Authority Revenue, 5.8 3,207,204 3,110,000(c)Delaware County Industrial Development Authorit 2,352,124 1,155,000 Hazleton Health Services Authority Hospital Rev 1,161,803 3,360,000 Montgomery County Higher Education & Health Aut 3,393,667 1,430,000 Pennsylvania Economic Development Financing Aut 1,375,774 1,805,000 Pennsylvania Economic Development Financing Aut 1,796,047 2,330,000 Pennsylvania Economic Development Financing Aut 2,316,276 5,000,000 Philadelphia Hospitals & Higher Education Facil 4,425,000 2,005,000 Scranton-Lackawanna Health & Welfare Authority 2,015,807 2,245,000 Scranton-Lackawanna Health & Welfare Authority 2,257,101 $ 29,431,213 Rhode Island - 3.9% 4,485,000 Central Falls Rhode Island Detention Facilities $ 4,800,699 8,285,000 Tobacco Settlement Financing Corp., 6.25%, 6/1/ 8,306,541 $ 13,107,240 South Carolina - 5.9% 1,500,000 Connector 2000 Association, Inc., Toll Road Rev $ 1,213,560 1,600,000 Loris Community Hospital District, 5.625%, 1/1/ 1,601,520 7,140,000+ South Carolina Jobs Economic Development Author 8,199,933 860,000 + South Carolina Jobs Economic Development Author 985,319 3,000,000+ South Carolina Jobs Economic Development Author 3,430,950 4,400,000 Tobacco Settlement Revenue Management, 6.375%, 4,407,392 $ 19,838,674 Tennessee - 2.5% 1,000,000+ Johnson City Health & Educational Facilities Bo $ 1,193,660 7,000,000 Knox County Health Educational & Housing Facili 7,152,600 $ 8,346,260 Texas - 14.9% 8,650,000 Brazos River Authority Pollution Control Revenu $ 8,313,861 4,000,000 Brazos River Authority Pollution Control Revenu 4,137,080 7,350,000 Gulf Coast Industrial Development Authority, 7. 7,055,485 10,000,000 Houston Texas Airport System Special Facilities 10,103,900 1,000,000 IAH Public Facility Corp., Project Revenue Bond 973,110 1,000,000 IAH Public Facility Corp., Project Revenue Bond 952,330 1,350,000 IAH Public Facility Corp., Project Revenue Bond 1,268,595 845,000 Lubbock Health Facilities Development Corp., 6. 847,374 2,000,000 Lubbock Health Facilities Development Corp., 6. 2,010,480 7,750,000 Matagorda County Navigation District Number 1 R 7,576,167 5,000,000 Tomball Hospital Authority, 6.0%, 7/1/25 5,069,100 1,500,000(d)Willacy County Local Government Corp., 6.0%, 3/ 1,527,195 $ 49,834,677 Utah - 0.5% 1,600,000 Spanish Fork Charter School Revenue, 5.7%, 11/1 $ 1,485,696 Washington - 7.0% 5,500,000 Port Seattle Washington Special Facilities Reve $ 5,617,590 1,345,000 Tobacco Settlement Authority Revenue, 6.5%, 6/1 1,388,780 6,960,000(a)Washington State Economic Development Finance A 7,689,965 2,000,000 Washington State Health Care Facilities Authori 1,953,120 2,000,000 Washington State Health Care Facilities Authori 1,952,800 5,000,000 Washington State Housing Finance Commission Non 4,692,250 $ 23,294,505 Wisconsin - 1.4% 3,000,000 Aztalan Wisconsin Exempt Facilities Revenue, 7. $ 2,715,690 1,000,000 Wisconsin State Health & Educational Facilities 1,003,740 1,000,000 Wisconsin State Health & Educational Facilities 964,930 $ 4,684,360 TOTAL TAX-EXEMPT OBLIGATIONS (Cost $439,847,066) $ 460,664,154 MUNICIPAL COLLATERALIZED DEBT OBLIGATION - 3.8% of Net Assets 13,000,000 Non-Profit Preferred Funding Trust I, Series E, $ 12,637,690 TOTAL MUNICIPAL COLLATERALIZED DEBT OBLIGATION (Cost $13,000,000) $ 12,637,690 Shares COMMON STOCK - 0.3% of Net Assets 80,678 Northwest Airlines Corp. $ 1,170,638 TOTAL COMMON STOCK (Cost $3,210,349) $ 1,170,638 TAX-EXEMPT MONEY MARKET MUTUAL FUND - 0.0% of Net Assets 45,820 BlackRock Liquidity Funds MuniFund Portfolio $ 45,820 TOTAL TAX-EXEMPT MONEY MARKET MUTUAL FUND (Cost $45,820) $ 45,820 TOTAL INVESTMENTS IN SECURITIES - 141.9% (Cost $456,103,235) (e)(f) $ 474,518,302 OTHER ASSETS AND LIABILITIES - 3.0% $ 9,824,103 PREFERRED SHARES AT REDEMPTION VALUE, INCLUDING DIVIDENDS PAYABLE - (44.9)% $ (150,009,450) NET ASSETS APPLICABLE TO COMMON SHAREOWNERS - 100.0% $ 334,332,955 (144A) Security is exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold normally to qualified institutional buyers in a transaction exempt from registration. At December 31, 2007, the value of these securities amounted to $47,390,455, or 14.2% of total net assets applicable to common shareowners. RIB Residual Interest Bonds. + Prerefunded bonds have been collateralized by U.S. Treasury or U.S. Government Agency securities which are held in escrow to pay interest and principal on the tax exempt issue and to retire the bonds in full at the earliest refunding date. (a) The interest rate is subject to change periodically and inversely based upon prevailing market rates. The interest rate shown is the rate at December 31, 2007. (b) Debt obligation initially issued at one coupon which converts to a higher coupon at a specific date. The rate shown is the rate at December 31, 2007. (c) Security is in default and is non-income producing. (d) Escrow to maturity. (e) The concentration of investments by type of obligation/market sector is as follows: Insured 12.5% General Obligation 5.3 Revenue Bonds: Health Revenue 26.6 Development Revenue 11.3 Airport Revenue 10.3 Tobacco Revenue 9.3 Facilities Revenue 6.7 Transportation Revenue 6.1 Pollution Control Revenue 6.1 Housing Revenue 1.7 Other Revenue 1.4 Education Revenue 1.3 Water Revenue 1.1 Power Revenue 0.3 100.0% (f) At December 31, 2007, the net unrealized gain on investments based on cost for federal income tax purposes of $452,460,201 was as follows: Aggregate gross unrealized gain for all investments in which there is an excess of value over tax c $ 32,158,575 Aggregate gross unrealized loss for all investments in which there is an excess of tax cost over va (10,100,474) Net unrealized gain $ 22,058,101 For financial reporting purposes net unrealized gain on investments was $18,415,067 and cost of investments aggregated $456,103,235. ITEM 2. CONTROLS AND PROCEDURES. (a) Disclose the conclusions of the registrant's principal executive officer or officers and principal financial officer or officers, or persons performing similar functions, about the effectiveness of the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Act (17 CFR 270.30a-3(c))) as of a date within 90 days of the filing date of the report that includes the disclosure required by this paragraph, based on their evaluation of these controls and procedures required by Rule 30a-3(b) under the Act (17 CFR270.30a-3(b))) and Rule 13a-15(b) or 15d-15(b) under the Exchange Act (17 CFR240.13a-15(b) or 240.15d-15(b)). The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report. (b) Disclose any change in the registrant's internal controls over financial reporting (as defined in Rule 30a-3(d) under the Act (17 CFR270.30a-3(d)) that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting. There were no significant changes in the registrant's internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 3. EXHIBITS. (a) A separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2 under the Act (17 CFR 270.30a-2). Filed herewith. SIGNATURES [See General Instruction F] Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. (Registrant) Pioneer Municipal High Income Advantage Trust By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr, President Date February 29, 2008 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr., President Date February 29, 2008 By (Signature and Title)* /s/ Vincent Nave Vincent Nave, Treasurer Date February 29, 2008 * Print the name and title of each signing officer under his or her signature.