Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
MURRAY JAMES E
  2. Issuer Name and Ticker or Trading Symbol
HUMANA INC [HUM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Operating Officer
(Last)
(First)
(Middle)
HUMANA INC., 500 WEST MAIN STREET
3. Date of Earliest Transaction (Month/Day/Year)
11/25/2009
(Street)

LOUISVILLE, KY 40202
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Humana Common               3,983 I See Footnote (1)
Humana Common 11/25/2009   M   20,000 A $ 12.995 160,488 D  
Humana Common 11/25/2009   F   6,257 D $ 41.535 154,231 D  
Humana Common 11/25/2009   M   80,300 A $ 21.275 234,531 D  
Humana Common 11/25/2009   F   58,206 D $ 41.895 176,325 D  
Humana Common 11/25/2009   S   68,000 D (2) 108,325 D  
Humana Common 11/30/2009   S   1,204 D (3) 107,121 D  
Humana Common               23,282 I See Footnote (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Options (8) $ 32.7               (10) 02/24/2012 Humana Common 110,000   110,000 D  
Options (5) $ 12.995 11/25/2009   M     20,000 03/13/2005(6) 03/13/2012 Humana Common 20,000 $ 12.995 0 D  
Options (5) $ 9.26             03/13/2006(7) 03/13/2013 Humana Common 13,686   13,686 D  
Options (8) $ 21.275 11/25/2009   M     80,300   (9) 02/24/2014 Humana Common 80,300 $ 21.275 0 D  
Options (8) $ 53.96               (11) 02/23/2013 Humana Common 84,720   84,720 D  
Options (8) $ 62.1               (12) 02/22/2014 Humana Common 67,042   67,042 D  
Options (8) $ 69.475               (13) 02/21/2015 Humana Common 70,673   70,673 D  
Options (8) $ 41.83               (14) 02/19/2016 Humana Common 99,979   99,979 D  
Phantom Stock Units (15)               (15)   (15) Humana Common 25,183   25,183 I See Footnote (15)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MURRAY JAMES E
HUMANA INC.
500 WEST MAIN STREET
LOUISVILLE, KY 40202
      Chief Operating Officer  

Signatures

 James E. Murray   11/30/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares held by reporting person's spouse.
(2) Reporting person sold a total of 68,000 shares at the following prices: 1,400 @ $41.90; 4,588 @ $41.91; 3,667 @ $41.92; 2,745 @ $41.93; 2,200 @ $41.94; 1,700 @ $41.96; 2,000 @ $41.97; 100 @ $41.98; 3,300 @ $41.98; 3,600 @ $41.99; 1,202 @ $42.00; 1,898 @ $42.01; 1,400 @ $42.02; 100 @ $42.03; 3,800 @ $42.03; 1,500 @ $42.04; 454 @ $42.05; 2,346 @ $42.06; 200 @ $42.07; 11,900 @ $42.07; 100 @ $42.08; 4,300 @ $42.08; 200 @ $42.09; 3,235 @ $42.09; 5,737 @ $42.10; 2,528 @ $42.11; 1,300 @ $42.12; 300 @ $42.13; 200 @ $42.14.
(3) Reporting person sold a total of 1,204 shares at the following prices: 300 @ $41.91; 800 @ $41.92; 100 @ $41.97; 4 @ $41.90.
(4) Stock units held for the benefit of reporting person as of October 31, 2009 under the Humana Retirement & Savings Plan, including a routine disposition of shares to fund an administrative fee assessment under a Tax-Conditioned Plan. All transactions are exempt under Rule 16b-3(c).
(5) Right to buy pursuant to Company's 1996 Stock Incentive Plan for Employees.
(6) Incentive Stock Options were granted to reporting person on 3/13/02 vesting in thirds from 3/13/03 to 3/13/05.
(7) Incentive and Non-Qualified Stock Options were granted to reporting person on 3/13/03 vesting in three increments each from 3/13/04 to 3/13/06.
(8) Right to buy pursuant to Company's 2003 Stock Incentive Plan.
(9) Incentive and Non-Qualified Stock Options were granted to reporting person on 2/24/04 vesting in three increments from 2/24/05 to 2/24/07, and ISO's vesting on 02/24/07.
(10) Incentive and Non-Qualified stock options granted to reporting person on 2/24/05, NQ options vesting in three increments from 2/24/06 to 2/24/08, and ISO's vesting on 2/24/08.
(11) Incentive and Non-Qualified stock options granted to reporting person on 2/23/06, NQ options vesting in three increments from 2/23/07 to 2/23/09, and ISO's vesting on 2/23/09.
(12) Incentive and Non-Qualified stock options granted to reporting person on 2/22/07, NQ options vesting in three increments from 2/22/08 to 2/22/10, and ISO's vesting on 2/22/10.
(13) Incentive and Non-Qualified stock options granted to reporting person on 2/21/08, NQ options vesting in three increments from 2/21/09 to 2/21/11, and ISO's vesting on 2/21/11.
(14) Reporting person was granted the maximum number of Incentive stock options allowed and remaining options were granted as Non-Qualified stock options. The option grant vests in three increments from 2/19/10 to 2/19/12.
(15) Phantom Stock Units held for the benefit of reporting person as of October 31, 2009 based on the value of Humana common stock on a 1-for-1 basis, under the Humana Excess Plan. All transactions are exempt under Rule 16b-3(c and d).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.