SCHEDULE 13G

Amendment No. 1
ULTRAGENYX PHARMA INC
COMMON STOCK
Cusip #90400D108
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[ ] 	  Rule 13d-1(b)
[x] 	  Rule 13d-1(c)
[ ] 	  Rule 13d-1(d)
Cusip #90400D108
Item 1: 	   	Reporting Person - FIL Limited
Item 2: 	   	(a)  	[ ]
   	   	(b)  	[ ]
Item 4: 	   	Bermuda
Item 5: 	   	517,014
Item 6: 	   	0
Item 7: 	   	517,014
Item 8: 	   	0
Item 9: 	   	517,014
Item 11: 	   	1.620%
Item 12: 	   	FI
Cusip #90400D108
Item 1: 	   	Reporting Person - Pandanus Partners, L.P.
Item 2: 	   	(a)  	[ ]
   	   	(b)  	[ ]
Item 4: 	   	Delaware
Item 5: 	   	0
Item 6: 	   	0
Item 7: 	   	517,014
Item 8: 	   	0
Item 9: 	   	517,014
Item 11: 	   	1.620%
Item 12: 	   	PN
Cusip #90400D108
Item 1: 	   	Reporting Person - Pandanus Associates, Inc.
Item 2: 	   	(a)  	[ ]
   	   	(b)  	[ ]
Item 4: 	   	Delaware
Item 5: 	   	0
Item 6: 	   	0
Item 7: 	   	517,014
Item 8: 	   	0
Item 9: 	   	517,014
Item 11: 	   	1.620%
Item 12: 	   	CO

Item 1(a). 	    	Name of Issuer:

  	  	          	ULTRAGENYX PHARMA INC

Item 1(b). 	    	Address of Issuer's Principal Executive Offices:

  	  	          	60 LEVERONI COURT
  	  	          	Novato, CA 94949
  	  	          	USA

Item 2(a). 	     	 Name of Person Filing:

  	   	               	 FIL Limited

Item 2(b). 	     	 Address or Principal Business Office or, if None,
Residence:

  	   	               	 Pembroke Hall, 42 Crow Lane, Hamilton, Bermuda,
HM19

Item 2(c). 	     	 Citizenship:

  	   	               	 Not applicable

Item 2(d). 	     	 Title of Class of Securities:

  	   	               	 COMMON STOCK

Item 2(e). 	     	 CUSIP Number:

  	   	               	 90400D108

Item 3. 	    	Not Applicable

Item 4. 	    	Ownership

  	  	     	(a)    Amount Beneficially Owned: 	517,014

  	  	     	(b)    Percent of Class: 	1.620%

  	  	     	(c)    Number of shares as to which such person has:

  	  	     	       (i)    sole power to vote or to direct the vote:
517,014

  	  	     	       (ii)    shared power to vote or to direct the vote: 	0

  	  	     	       (iii)    sole power to dispose or to direct the
disposition of: 	517,014

  	  	     	       (iv)    shared power to dispose or to direct the
disposition of: 	0



Item 5. 	    	Ownership of Five Percent or Less of a Class.

  	    	     	If this statement is being filed to report the fact that as
of the date hereof, the reporting person has ceased to be the beneficial
owner of more than five percent of the class of securities, check the
following (X).

Item 6. 	    	Ownership of More than Five Percent on Behalf of Another
Person.

  	    	     	Not applicable.

Item 7. 	    	Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding Company.

  	    	     	See attached Exhibit A.

Item 8. 	    	Identification and Classification of Members of the Group.

  	    	     	Not applicable.

Item 9. 	    	Notice of Dissolution of Group.

  	    	  	Not applicable.

Item 10. 	    	Certifications.



In as much as the reporting persons are no longer the beneficial owners of
more than five percent of the number of shares outstanding, the reporting
persons have no further reporting obligation under Section 13(d) of the
Securities and Exchange Commission thereunder, and the reporting persons
have no obligation to amend this Statement if any material change occurs in
the facts set forth herein.


Signature



After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

  	February 13, 2015
  	Date

  	/s/ Scott C. Goebel
  	Signature

  	Scott C. Goebel
  	 Duly authorized under Power of Attorney effective as of May 5, 2014, by
and on behalf of FIL Limited and its direct and indirect subsidiaries*



        * This power of attorney is incorporated herein by reference to
Exhibit B to the Schedule 13G filed by FIL Limited on June 10, 2014,
accession number: 0000318989-14-000096.



Exhibit A


                 Pursuant to the instructions in Item 7 of Schedule 13G,
the following table lists the identity and Item 3 classification, if
applicable, of each relevant entity that beneficially owns shares of the
security class being reported on this Schedule 13G.


Entity 	ITEM 3 Classification
FIL INVESTMENTS INTERNATIONAL 	FI



                Pandanus Partners, L.P. ("Pandanus") owns shares of FIL
Limited ("FIL") voting stock. While the percentage of total voting power
represented by these shares of FIL voting stock may fluctuate as a result
of changes in the total number of shares of FIL voting stock outstanding
from time to time, it normally represents more than 25% and less than 50%
of the total votes which may be cast by all holders of FIL voting stock.
Pandanus Associates, Inc. ("PAI") acts as general partner of Pandanus.
Pandanus is owned by trusts for the benefit of members of the family of
Edward C. Johnson 3d but disclaims that any such member is a beneficial
owner of the securities reported on this Schedule 13G.



                This filing reflects the securities beneficially owned, or
that may be deemed to be beneficially owned, by FIL, certain of its
subsidiaries and affiliates, and other companies (collectively, the "FIL
Reporters"). This filing does not reflect securities, if any, beneficially
owned by certain other companies whose beneficial ownership of securities
is disaggregated from that of the FIL Reporters in accordance with
Securities and Exchange Commission Release No. 34-39538 (January 12, 1998).


RULE 13d-1(k)(1) AGREEMENT


                The undersigned persons, on February 13, 2015, agree and
consent to the joint filing on their behalf of this Schedule 13G in
connection with their beneficial ownership of the COMMON STOCK of
ULTRAGENYX PHARMA INC at December 31, 2014.


  	FIL Limited

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of May 5, 2014, by
and on behalf of FIL Limited and its direct and indirect subsidiaries*

  	Pandanus Partners, L.P.

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of May 2, 2014, by
Pandanus Associates, Inc. on behalf of Pandanus Partners, L.P.*

  	Pandanus Associates, Inc.

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of May 2, 2014, by
and on behalf of Pandanus Associates, Inc.*



        * This power of attorney is incorporated herein by reference to
Exhibit B to the Schedule 13G filed by FIL Limited on June 10, 2014,
accession number: 0000318989-14-000096.