SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): April 13, 2006

                          IR BIOSCIENCES HOLDINGS, INC.
             (Exact name of registrant as specified in its charter)



                                   Delaware
                               ------------------
                          (State or other jurisdiction
                                of incorporation)

      033-05384                                          13-3301899
 ------------------                                  ------------------
  (Commission                                         (IRS Employer
   File Number)                                        Identification No.)




 4021 North 75th Street, Suite 201 Scottsdale, Arizona          85251
--------------------------------------------------------------------------
 (Address of principal executive offices)                    (Zip Code)


                                   480-922-3926
             ------------------------------------------------------
               Registrant's telephone number, including area code

                                   Not applicable
             ------------------------------------------------------
        (Former name or former address, if changed since last report.)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_| Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

|_| Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

|_| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))

|_| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))





ITEM 1.01  ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT

Effective April 13, 2006, IR BioSciences Holdings,  Inc. (the "Company") entered
into an unsecured Senior Promissory Note in the amount of $500,000 (the "Note").
Following  the payment of  commissions  and expenses,  the Company  received net
proceeds of  approximately  $439,875.  The outstanding  principal  amount of the
Note,  plus  interest  at the rate of 12% per  annum,  is  payable in cash on or
before the earlier of (i) April 12, 2007 or (ii) the date upon which the Company
sells any of its equity or debt  securities  in a  financing  transaction,  or a
series  of  financings,   with  gross  proceeds  equal  to  $1,000,000  or  more
("Subsequent  Financing  Transaction");  provided,  however,  that a  Subsequent
Financing  Transaction  will  not  include  (x)  issuances  of  common  stock to
employees  of the Company,  (y) the  exercise of any options to purchase  common
stock of the Company  that are  outstanding  as of the date  hereof,  or (z) the
grant,  issuance or exercise of options or common stock of the Company under the
Company's  stock,  option,  deferred  stock and  restricted  stock  plan for the
purpose of satisfying the Company's payables.

Pursuant to the terms of the Note,  the Company  agreed to use the proceeds from
the Note for working capital and general  corporate  purposes.  The Company also
agreed not to engage in any of the following  actions,  among others, so long as
the Note  remains  outstanding  or any other amount is owed to the holder of the
Note:  (i)  increase  the base salary of any officer of the Company more than 5%
per year unless required to do so by an outstanding  employment agreement,  (ii)
pay any dividends, (iii) incur indebtedness which is senior or pari passu to the
Note, (iv) sell account receivables, (v) expend more than $100,000 in any fiscal
year for capital  expenditures,  or (vi) advance money to or invest in any firm,
corporation  or other person,  except in certain  enumerated  situations.  In an
event of default,  as defined in the Note, the Note shall become immediately due
and payable,  and during the  continuation  of an event of default,  the Company
must pay interest on the Note in an amount equal to 2% per month until the event
of default is cured or waived.

The Note was sold to one  investor  whom the Company had  reasonable  grounds to
believe  was  an  "accredited  investor"  within  the  meaning  of  Rule  501 of
Regulation  D under the  Securities  Act of 1933,  as amended  (the  "Securities
Act").  The  investor was provided  access to business and  financial  about the
Company and had such knowledge and experience in business and financial  matters
that it was able to  evaluate  the risks  and  merits  of an  investment  in the
Company.  The  Note  included  a  legend  to the  effect  that  the Note was not
registered under the Securities Act and could not be resold absent  registration
or the  availability of an applicable  exemption from  registration.  No general
solicitation  or advertising was used in connection  with the  transaction.  The
Company paid Joseph Stevens & Company,  Inc. a placement  agent fee equal to 10%
of the face amount of the Note, or $50,000.

The issuance of the Note was exempt from the  registration  requirements  of the
Securities Act by reason of Section 4(2) of the Securities Act and the rules and
regulations, including Regulation D thereunder, as transactions by an issuer not
involving a public offering.

The above  description,  which summarizes the material terms of the Note, is not
complete.  Please read the full text of the Note,  which has been filed with the
Securities and Exchange Commission as Exhibits 10.1 to this Form 8-K.

ITEM 2.03  CREATION OF A DIRECT  FINANCIAL  OBLIGATION OR AN OBLIGATION UNDER AN
           OFF-BALANCE SHEET ARRANGEMENT OF A REGISTRANT.

The  information  set forth  above  under  Item 1.01 is hereby  incorporated  by
reference into this Item 2.03.


ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS

(d) Exhibits

10.1     Unsecured 12% Senior Promissory Note dated April 13, 2006.






                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

IR Biosciences Holdings, Inc.

Date: April 19, 2006

By:     /s/ Michael K. Wilhelm
        -----------------------
        Name:         Michael K. Wilhelm
        Title:       Chief Executive Officer







                                  EXHIBIT INDEX

10.1     Unsecured 12% Senior Promissory Note dated April 13, 2006.