Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Watson Pacicco Kelli
 2. Date of Event Requiring Statement (Month/Day/Year)
02/12/2008		 3. Issuer Name and Ticker or Trading Symbol
MEDICINES CO /DE [MDCO]
(Last)
(First)
(Middle)
THE MEDICINES COMPANY, 8 CAMPUS DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Senior Vice President
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

PARSIPPANY, NJ 07054		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Option (right to buy)   (1) 01/01/2017 Common Stock 48,000 $ 31.5 D  
Option (right to buy)   (2) 07/27/2017 Common Stock 16,000 $ 16.5 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Watson Pacicco Kelli
THE MEDICINES COMPANY
8 CAMPUS DRIVE
PARSIPPANY, NJ 07054		       Senior Vice President  

Signatures

/s/ Kelli Watson-Pacicco 02/13/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) As of 2/12/08, the original grant (48,000 shares granted on 1/1/07) was vested with respect to 13,000 of the shares covered thereby, none of which options had been exercised. The remaining 35,000 shares covered by this option vest in equal monthly installments ending on 1/1/11.
(2) As of 2/12/08, none of the options covered by the original grant (16,000 shares granted on 7/27/07) had vested. This grant vests 25% on 7/27/08 and in equal monthly installments thereafter ending on 7/27/11.

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