FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * HERON ELAINE J   2. Issuer Name and Ticker or Trading Symbol BIOMARIN PHARMACEUTICAL INC [BMRN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O BIOMARIN PHARMACEUTICAL INC., 105 DIGITAL DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 11/07/2012 (Street) NOVATO, CA 94949 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/07/2012 11/07/2012 M   30,000 A $ 7.46 75,900 D   Common Stock 11/07/2012 11/07/2012 M   30,000 A $ 14.93 105,900 D   Common Stock 11/07/2012 11/07/2012 M   15,000 A $ 17.33 120,900 D   Common Stock 11/07/2012 11/07/2012 M   15,000 A $ 38.59 135,900 D   Common Stock 11/07/2012 11/07/2012 M   15,000 A $ 14.39 150,900 D   Common Stock 11/07/2012 11/07/2012 S   105,000 D $ 46.4392 (1) 45,900 D   Common Stock 11/09/2012 11/09/2012 S   30,000 D $ 48.0117 (2) 15,900 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (right to buy)

$ 7.46

11/07/2012

11/07/2012

M

30,000

10/12/2005(3)

07/11/2015

Common Stock

30,000

$ 0

113,500

D

Stock Option (right to buy) Common Stock

$ 14.93

11/07/2012

11/07/2012

M

30,000

10/12/2006(4)

07/11/2016

Common Stock

30,000

$ 0

83,500

D

Stock Option (right to buy) Common Stock

$ 17.33

11/07/2012

11/07/2012

M

15,000

09/07/2007(5)

06/07/2017

Common Stock

15,000

$ 0

68,500

D

Stock Option (right to buy) Common Stock

$ 38.59

11/07/2012

11/07/2012

M

15,000

08/22/2009(6)

05/21/2018

Common Stock

15,000

$ 0

53,500

D

Stock Option (right to buy) Common Stock

$ 14.39

11/07/2012

11/07/2012

M

15,000

08/12/2009(7)

05/11/2019

Common Stock

15,000

$ 0

38,500

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
HERON ELAINE J C/O BIOMARIN PHARMACEUTICAL INC. 105 DIGITAL DRIVE NOVATO, CA 94949	X

Signatures

/s/ Laura Randall Woodhead, Attorney-in-Fact		11/09/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The price in Column 4 is a weighted average price. The prices actually received ranged from $46.285 to $46.64. The reporting person will provide to the issue, any security holder of the issuer, or SEC staff, upon request, information regarding the number of shares sold at each price within the range.
(2)	The price in Column 4 is a weighted average price. The prices actually received ranged from $47.49 to $48.56. The reporting person will provide to the issue, any security holder of the issuer, or SEC staff, upon request, information regarding the number of shares sold at each price within the range.
(3)	Options vest 1/4th each on October 12, 2005, January 12, 2006, April 12, 2006 and July 12, 2006.
(4)	Options vest 1/4th each on October 12, 2006, Januray 12, 2007, April 12, 2007 and July 12, 2007.
(5)	Options vest 1/4th each on September 7, 2007, December 7, 2007, March 7, 2008 and June 7, 2008.
(6)	Options vest 1/4th each on August 22, 2008, November 22, 2008, February 22, 2009 and May 22, 2009.
(7)	Options vest 1/4th each on August 12, 2009, November 12, 2009, February 12, 2010 and May 12, 2010.

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