Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
PAZ GEORGE
   2. Issuer Name and Ticker or Trading Symbol
EXPRESS SCRIPTS INC [ESRX] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman, President & CEO
(Last)
(First)
(Middle)
C/O EXPRESS SCRIPTS, INC., ONE EXPRESS WAY		 3. Date of Earliest Transaction (Month/Day/Year)
11/15/2010
(Street)

ST. LOUIS, MO 63121		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/15/2010   M(1)   144,016 A $ 8.6638 757,920 (2) D  
Common Stock 11/15/2010   S(1)   144,016 D $ 51.9664 613,904 (2) D  
Common Stock 11/15/2010   M(1)   166,312 A $ 9.395 780,216 (2) D  
Common Stock 11/15/2010   S(1)   166,312 D $ 51.9664 613,904 (2) D  
Common Stock 11/15/2010   M(1)   100,540 A $ 9.66 714,444 (2) D  
Common Stock 11/15/2010   S(1)   100,540 D $ 51.9664 613,904 (2) D  
Common Stock 11/16/2010   M(1)   106,500 A $ 9.66 720,404 (2) D  
Common Stock 11/16/2010   S(1)   106,500 D $ 51.2858 613,904 (2) D  
Common Stock 11/16/2010   M(1)   320,000 A $ 10.7 933,904 (2) D  
Common Stock 11/16/2010   S(1)   320,000 D $ 51.2858 613,904 (2) D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (Right-to-Buy) (3) $ 8.6638 11/15/2010   M     144,016   (4) 02/10/2011 Express Scripts, Inc. Common Stock 144,016 (7) 0 D  
Non-Qualified Stock Option (Right-to-Buy) (3) $ 9.395 11/15/2010   M     166,312   (5) 03/05/2011 Express Scripts, Inc. Common Stock 166,312 (7) 0 D  
Non-Qualified Stock Option (Right-to-Buy) (3) $ 9.66 11/15/2010   M     100,540   (5) 03/01/2012 Express Scripts, Inc. Common Stock 100,540 (7) 106,500 D  
Non-Qualified Stock Option (Right-to-Buy) (3) $ 9.66 11/16/2010   M     106,500   (5) 03/01/2012 Express Scripts, Inc. Common Stock 106,500 (7) 0 D  
Non-Qualified Stock Option (Right-to-Buy) (3) $ 10.7 11/16/2010   M     320,000   (6) 04/11/2012 Express Scripts, Inc. Common Stock 320,000 (7) 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PAZ GEORGE
C/O EXPRESS SCRIPTS, INC.
ONE EXPRESS WAY
ST. LOUIS, MO 63121		   X     Chairman, President & CEO  

Signatures

 George Paz   11/17/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Reporting Person on May 14, 2010.
(2) Reporting Person's shares beneficially owned have been adjusted to reflect the Company's 2-for-1 stock split effective on June 7, 2010.
(3) The number of shares and exercise price have been adjusted to reflect the Company's 2-for-1 stock split effective on June 7, 2010.
(4) Options vested in three (3) equal installments on December 31, 2004, December 31, 2005, and December 31, 2006.
(5) Options vested in three (3) equal installments on the first three anniversaries of the grant date.
(6) Options vested in three (3) equal installments on March 31, 2006, March 31, 2007, and March 31, 2008.
(7) Employee stock option granted pursuant to Express Scripts, Inc. 2000 Long-Term Incentive Plan.

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