UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM N-CSR

 

CERTIFIED SHAREHOLDER REPORT OF REGISTERED
MANAGEMENT INVESTMENT COMPANIES

 

Investment Company Act file number

811-4889

 

H&Q Healthcare Investors

(Exact name of registrant as specified in charter)

 

30 Rowes Wharf, Fourth Floor, Boston, MA

 

02110-3328

(Address of principal executive offices)

 

(Zip code)

 

30 Rowes Wharf, Fourth Floor, Boston, MA 02110-3328

(Name and address of agent for service)

 

Registrant’s telephone number, including area code:

617-772-8500

 

 

Date of fiscal year end:

September 30

 

 

Date of reporting period:

October 1, 2005 to March 31, 2006

 

 

Form N-CSR is to be used by management investment companies to file reports with the Commission not later than 10 days after the transmission to stockholders of any report that is required to be transmitted to stockholders under Rule 30e-1 under the Investment Company Act of 1940 (17 CFR 270.30e-1). The Commission may use the information provided on Form N-CSR in its regulatory, disclosure review, inspection, and policymaking roles.

 

A registrant is required to disclose the information specified by Form N-CSR, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-CSR unless the Form displays a currently valid Office of Management and Budget (“OMB”) control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. Section 3507.

 



 

ITEM 1.                             REPORTS TO STOCKHOLDERS.

 



H&Q HEALTHCARE INVESTORS

Semiannual Report

March 31, 2006




To our Shareholders:

On March 31, 2006, the net asset value per share of the Fund was $19.64. During the six-month period ended March 31, 2006, total return at net asset value of your Fund was 4.85%. During the most recent quarter ended March 31, 2006, total return at net asset value of your Fund was 7.83%. The total investment return at market was 5.52% during the six-month period ended March 31, 2006 and was 6.62% during the quarter ended March 31, 2006. Comparisons to relevant indices are listed below:

Investment Returns   Quarter
Ended
3/31/06
  Six Months
Ended
3/31/06
 
Investment Return at Market     +6.62 %     +5.52 %  
Net Asset Value     +7.83 %     +4.85 %  
NASDAQ Biotech Index (NBI)     +6.44 %     +7.18 %  
S&P 500 Index     +4.21 %     +6.38 %  

 

In the most recent quarter ended March 31, 2006, the investment return at market value and net asset value (NAV) of your Fund each returned more than 6% and 7% respectively, outperforming the NASDAQ Biotech Index (NBI) and the S&P 500 Index (S&P) for the period. In that same period, the NBI outperformed the S&P. However, for the six-month period ending 3/31/06, investment return at market and NAV underperformed these benchmark indexes.

In the approximately six weeks since the end of March 2006, the S&P index has been flat to slightly down, while the Fund and the NBI have exhibited a somewhat larger retreat. We think that this trend evidences some profit taking in biotechnology as well as some market rotation out of smaller capitalization healthcare investments into other non-healthcare sectors as well some movement into large pharma. We also think that these trends have been exacerbated by macroeconomic factors (e.g., inflation fears resulting from increased energy and hard commodity pricing, Federal Reserve actions, etc.) as well as by some momentum buying as the largest cap segments of the market (e.g., the Dow Jones Industrial Average) approached multi-year highs. Certain regulatory events have also been an impediment to advancement of the group. For example, CMS' initial proposal regarding re-setting of reimbursement for medical products was not well received by the marketplace. We expect that final negotiations to be played out over time will moderate the impact of any proposal adopted by CMS, but the initial proposal provided for significant reductions in Medicare reimbursement rates for a number of important products.

1



In the first half of calendar year 2005, a number of events in biotechnology sectors were well received by investors and, in our view, helped move the sector upward. Examples included positive results for Genzyme's Renagel product and for Genetech's Herceptin and Lucentis products. Also, Teva Pharmaceuticals obtained approval for generic versions of several prominent drugs, Amylin successfully launched a new drug, Byetta, for use in diabetes and Myogen demonstrated successful clinical data for a new heart failure drug. In aggregate, we believe that these and other events had a benefical effect on the sector. More recently there have been several program or product developments that we believe have had a negative impact on the sector. These include delays in key programs at Dov Pharmaceuticals and Encysive Pharmaceuticals, as well as failure of a clinical trial at Rigel Pharmaceuticals and at Inhibitex. We believe that these events, in combination with other events and macroeconomic factors have had a negative short term effect on the NBI and the sector generally. While we are not happy about these developments, we think that the biotech sector is approaching an oversold situation which may well present a buying opportunity for us in the not too distant future.

In the broader healthcare sectors, several trends have emerged of late. It appears that after multi-year stock price advancement, the Payer (i.e., HMO) and Provider (i.e., Hospital) sub-sectors of the Healthcare Market have slowed or even re-traced some gains of late. In addition, a number of the largest and probably best biotech companies, such as Genzyme, Gilead, Genentech and Amgen, have also retreated a bit after significant advancement in calendar year 2005. This recent price action may also produce a buying opportunity in the not too distant future.

During the six-month period ended March 31, 2006, within the public portfolio, the Fund established positions in several companies including Amgen, Inc., National Medical Health Card Systems, Inc., Idenix Pharmaceuticals, Inc., Imclone Systems, Inc., DJ Orthopedics Inc., and Myriad Genetics Inc. During the same six-month period, the Fund exited its positions in Millennium Pharmaceuticals, Inc., OSI Pharmaceuticals, Inc., Nuvelo, Inc., Alkermes, Inc., Intralase Corporation, and Medarex, Inc.

Within the venture and restricted securities portfolio during the six-month period ended March 31, 2006, the Fund made follow on investments in Xanthus Life Sciences, Inc. The Fund also increased its investment in Ceres, Inc. by participating in a cashless exercise of warrants. The Fund established positions in Akorn, Inc., Aveta, Inc., Cougar Biotechnology Inc. and Medwave, Inc.

2



As always, if you have any questions or comments, please call me at 617-772-8500. I would be happy to speak with you.

Daniel R. Omstead
President

3



H&Q HEALTHCARE INVESTORS

LARGEST HOLDINGS BY ISSUER

As of March 31, 2006

    % of Net Assets  
Conor Medsystems, Inc.     3.80 %  
Gilead Sciences, Inc.     3.36 %  
Genzyme Corp.     2.82 %  
Teva Pharmaceutical Industries, Ltd.     2.75 %  
Cubist Pharmaceuticals, Inc.     2.66 %  
Concentric Medical, Inc.     2.39 %  
Theravance, Inc.     2.09 %  
Medtronic, Inc.     2.08 %  
IDEXX Laboratories, Inc.     2.04 %  
Impax Laboratories, Inc.     1.94 %  

 

H&Q HEALTHCARE INVESTORS

PORTFOLIO

As of March 31, 2006

4




H&Q HEALTHCARE INVESTORS

SCHEDULE OF INVESTMENTS

March 31, 2006

(Unaudited)

      CONVERTIBLE SECURITIES - 13.6% of Net Assets        
SHARES   Convertible Preferred (Restricted) - 13.5%   VALUE  
    Drug Discovery Technologies - 1.4%  
  2,380,953     Agilix Corporation Series B (a) (b)   $ 571,429    
  375,000     Ceres, Inc. Series C (a)     2,250,000    
  32,193     Ceres, Inc. Series C-1 (a) (c)     193,158    
  280,105     Ceres, Inc. Series D (a) (c)     1,680,630    
  845,375     Cougar Biotechnology Inc. Series A (a)     1,462,499    
  1,398,732     Galileo Pharmaceuticals, Inc. Series F-1 (a)     140    
  300,000     Zyomyx, Inc. Series A New (a)     30,000    
  300     Zyomyx, Inc. Series B New (a)     30    
    Emerging Biopharmaceuticals - 3.8%  
  1,117,381     Agensys, Inc. Series C (a)     3,300,300    
  2,586,207     Corus Pharma, Inc. Series C (a)     1,500,000    
  1,818,182     Raven biotechnologies, Inc. Series B (a)     1,509,091    
  2,809,157     Raven biotechnologies, Inc. Series C (a)     2,331,600    
  4,083,022     Raven biotechnologies, Inc. Series D (a)     1,200,000    
  2,123,077     TargeGen, Inc. Series C (a)     2,760,000    
  47,407     Therion Biologics Corporation Series A (a)     57,837    
  240,000     Therion Biologics Corporation Series B (a)     292,800    
  407,712     Therion Biologics Corporation Series C (a) (c)     497,409    
  33,332     Therion Biologics Corporation Series C-2 (a) (c)     40,665    
  36,092     Therion Biologics Corporation Sinking Fund (a)     361    
  2,555,000     Xanthus Life Sciences, Inc. Series B (a)     2,555,000    
    Healthcare Services - 3.9%  
  1,577,144     CardioNet, Inc. Series C (a) (b)     5,520,004    
  484,829     CytoLogix Corporation Series A (a) (b)     399,984    
  227,130     CytoLogix Corporation Series B (a) (b) (c)     187,382    
  160,000     I-trax, Inc. Series A (a)     5,584,000    
  5,384,615     PHT Corporation Series D (a) (b)     4,200,000    
  1,204,495     PHT Corporation Series E (a) (b)     939,506    
    Medical Devices and Diagnostics - 4.4%  
  4,852,940     Concentric Medical, Inc. Series B (a) (b) (d)     6,794,116    
  1,744,186     Concentric Medical, Inc. Series C (a) (b)     2,441,860    
  683,000     Concentric Medical, Inc. Series D (a) (b)     956,200    
  222,222     EPR, Inc. Series A (a)     2,222    
  3,669,024     Labcyte, Inc. Series C (a)     1,920,000    
  160,000     Masimo Corporation Series D     1,760,000    
  1,632,653     OmniSonics Medical Technologies, Inc.
Series B (a) (b)
    2,181,224    
  1,547,988     OmniSonics Medical Technologies, Inc.
Series C (a) (b)
    1,800,001    
  65,217     TherOx, Inc. Series H (a)     247,825    
  149,469     TherOx, Inc. Series I (a) (c)     577,100    
    $ 57,744,373    

 

The accompanying notes are an integral part of these financial statements.

5



H&Q HEALTHCARE INVESTORS

SCHEDULE OF INVESTMENTS

March 31, 2006

(Unaudited)

(continued)

PRINCIPAL
AMOUNT
  Convertible Notes (Restricted) - 0.1%   VALUE  
    Healthcare Services - 0.1%  
$ 300,000     CardioNet, Inc. Cvt. Note, 8.00% due 2006 (b) (c)   $ 300,000    
  168,337     CytoLogix Corporation Cvt. Note, 6.75% (b) (e)     168,337    
    $ 468,337    
        TOTAL CONVERTIBLE SECURITIES
(Cost $68,062,993)
  $ 58,212,710    
SHARES   COMMON STOCKS - 85.6%    
    Biopharmaceuticals - 29.0%  
  577,778     Akorn, Inc. (Restricted) (a) (c)   $ 2,386,801    
  373,750     Alexza Pharmaceuticals, Inc. (a)     3,644,063    
  98,800     Amgen, Inc. (a)     7,187,700    
  50,000     Biogen Idec Inc. (a)     2,355,000    
  493,886     Cubist Pharmaceuticals, Inc. (a)     11,344,561    
  512,859     Encysive Pharmaceuticals Inc. (a)     2,507,881    
  129,400     Endo Pharmaceuticals Holdings (a)     4,245,614    
  154,500     Forest Laboratories, Inc. (a)     6,895,335    
  51,500     Genentech, Inc. (a)     4,352,265    
  178,893     Genzyme Corporation (a)     12,025,187    
  230,825     Gilead Sciences, Inc. (a)     14,361,931    
  404,675     Idenix Pharmaceuticals Inc. (a)     5,491,440    
  140,500     Imclone Systems, Inc. (a)     4,779,810    
  246,623     Inhibitex Inc. (a)     1,790,483    
  778,450     Insmed Inc. (a)     1,517,978    
  1,048,756     Inspire Pharmaceuticals, Inc. (a)     5,484,993    
  158,690     MedImmune, Inc. (a)     5,804,880    
  408,000     MGI Pharma, Inc. (a)     7,140,000    
  168,960     Myriad Genetics Inc. (a)     4,408,166    
  124,080     PDL BioPharma Inc. (a)     4,069,824    
  165,000     Pfizer, Inc.     4,111,800    
  63,300     Pharmion Corporation (a)     1,140,666    
  278,300     Schering-Plough Corporation     5,284,917    
  392,849     Vivus, Inc. (a)     1,308,187    
      123,639,482    
    Drug Delivery - 2.7%  
  822,533     DepoMed, Inc. (a)     5,371,140    
  262,990     Noven Pharmaceuticals, Inc. (a)     4,736,450    
  56,806     Penwest Pharmaceuticals Co. (a)     1,232,122    
      11,339,712    
    Drug Discovery Technologies - 2.4%  
  69,840     Avalon Pharmaceuticals, Inc. (a)     352,692    
  207,432     Avalon Pharmaceuticals, Inc. (Restricted) (a)     995,155    

 

The accompanying notes are an integral part of these financial statements.

6



H&Q HEALTHCARE INVESTORS

SCHEDULE OF INVESTMENTS

March 31, 2006

(Unaudited)

(continued)

SHARES   Drug Discovery Technologies - continued   VALUE  
  93,931     Cougar Biotechnology Inc. (Restricted) (a)   $ 162,501    
  213,513     Senomyx, Inc. (a)     3,514,424    
  238,550     ZymoGenetics, Inc. (a)     5,157,451    
  300,000     Zyomyx, Inc. (Restricted) (a)     3,000    
      10,185,223    
    Emerging Biopharmaceuticals - 13.4%  
  391,698     ACADIA Pharmaceuticals, Inc. (a)     6,259,334    
  826,591     Ariad Pharmaceuticals, Inc. (a)     5,438,969    
  453,772     Barrier Therapeutics, Inc. (a)     4,392,513    
  86,930     DOV Pharmaceutical, Inc. (a)     1,389,141    
  465,050     Exelixis, Inc. (a)     5,585,250    
  677,239     Kosan Biosciences, Inc. (a)     3,988,938    
  60,500     Momenta Pharmaceuticals, Inc. (a)     1,189,430    
  62,073     Myogen, Inc. (a)     2,248,905    
  102,176     Myogen, Inc. warrants (a)     2,904,864    
  599,790     Neurogen Corporation (a)     3,712,700    
  297,663     Nitromed, Inc. (a)     2,500,369    
  626,580     Seattle Genetics, Inc. (a)     3,233,153    
  51,454     Telik, Inc. (a)     996,149    
  690,556     Tercica, Inc. (a)     4,626,725    
  318,291     Theravance, Inc. (a)     8,924,880    
  226,760     Therion Biologics Corporation (Restricted) (a)     2,268    
      57,393,588    
    Generic Pharmaceuticals - 9.3%  
  119,700     Barr Pharmaceuticals, Inc. (a)     7,538,706    
  828,524     Impax Laboratories, Inc. (a)     8,276,955    
  155,600     K-V Pharmaceutical Co. (a)     3,753,072    
  183,000     Medicis Pharmaceutical Corporation     5,965,800    
  177,500     Taro Pharmaceuticals Industries Ltd. (a)     2,474,350    
  285,569     Teva Pharmaceutical Industries, Ltd. ADR     11,759,731    
      39,768,614    
    Healthcare Services - 10.1%  
  131,000     Allscripts Healthcare Solutions, Inc. (a)     2,398,610    
  222,222     Aveta, Inc. (Restricted) (a)     2,999,997    
  26,125     DakoCytomation, Inc. (Restricted) (f)     271,961    
  239,000     Eclipsys Corporation (a)     5,642,790    
  389,319     Emageon, Inc. (a)     6,614,530    
  646,500     Emdeon Corporation (a)     6,982,200    
  141,000     Medco Health Solutions, Inc. (a)     8,068,020    
  198,905     National Medical Health Card Systems, Inc. (a)     5,569,340    
  306,208     Syntiro Healthcare Services (Restricted) (a)     306    
  625,000     Tenet Healthcare Corporation (a)     4,612,500    
      43,160,254    

 

The accompanying notes are an integral part of these financial statements.

7



H&Q HEALTHCARE INVESTORS

SCHEDULE OF INVESTMENTS

March 31, 2006

(Unaudited)

(continued)

SHARES   Medical Devices and Diagnostics - 18.7%   VALUE  
  187,780     Adeza Biomedical Corporation (a)   $ 3,967,791    
  164,150     Affymetrix, Inc. (a)     5,405,460    
  852,150     Align Technology, Inc. (a)     7,814,216    
  57,500     Boston Scientific Corporation (a)     1,325,375    
  447,722     Conor Medsystems, Inc. (a)     13,163,027    
  109,200     Conor Medsystems, Inc. (Restricted) (a)     3,049,956    
  120,000     DJ Orthopedics Inc. (a)     4,771,200    
  136,000     Gen-Probe, Inc. (a)     7,496,320    
  28,500     Guidant Corporation     2,224,710    
  100,980     IDEXX Laboratories, Inc. (a)     8,720,633    
  160,000     Masimo Corporation (Restricted) (a)     1,600    
  175,000     Medtronic, Inc.     8,881,250    
  830,292     Medwave, Inc. (Restricted) (a) (c)     2,690,146    
  369,583     Orchid Cellmark, Inc. (a)     2,121,406    
  1,020,000     Orthovita, Inc. (a)     4,222,800    
  208,529     Songbird Hearing, Inc. (Restricted) (a)     2,085    
  546,875     VNUS Medical Technologies, Inc. (a)     4,150,781    
      80,008,756    
        TOTAL COMMON STOCKS
(Cost $293,806,651)
  $ 365,495,629    
PRINCIPAL
AMOUNT
  SHORT-TERM INVESTMENT - 1.4%  
 
$ 6,000,000     General Electric Capital Corp.; 4.63% due
04/03/06 (Cost $5,998,456)
  $ 5,998,456    
        TOTAL INVESTMENTS - 100.6%
(Cost $367,868,100)
  $ 429,706,795    
        OTHER LIABILITIES IN EXCESS OF
ASSETS - (0.6%)
  $ (2,644,492 )  
        NET ASSETS - 100%   $ 427,062,303    

 

(a)  Non-income producing security.

(b)  Affiliated issuers in which the Fund holds 5% or more of the voting securities (Total Market Value of $26,460,043).

(c)  Including associated warrants.

(d)  Includes 321,000 non-voting shares.

(e)  Variable maturity.

(f)  Foreign Security.

ADR  American Depository Receipt.

The accompanying notes are an integral part of these financial statements.

8



H&Q HEALTHCARE INVESTORS

STATEMENT OF ASSETS AND LIABILITIES

March 31, 2006

(Unaudited)

ASSETS:  
Investments in non affiliated issuers, at value
(identified cost $341,307,215;
see Schedule of Investments)
  $ 403,246,752    
Investments in affiliated issuers, at value
(identified cost $26,560,885;
see Schedule of Investments)
    26,460,043    
Cash     72,376    
Interest and dividends receivable     66,088    
Receivable for investments sold     799,209    
Prepaid expenses     51,082    
Total assets   $ 430,695,550    
LIABILITIES:  
Payable for investments purchased   $ 3,071,495    
Accrued advisory fee     416,613    
Accrued audit fee     44,184    
Accrued administration fee     5,199    
Accrued legal fees     15,085    
Accrued shareholder reporting fees     63,874    
Accrued other     16,797    
Total liabilities   $ 3,633,247    
NET ASSETS   $ 427,062,303    
SOURCES OF NET ASSETS:  
Shares of beneficial interest, par value $.01 per
share, unlimited number of shares authorized,
amount paid in on 21,749,270 shares issued and
outstanding
  $ 353,294,931    
Accumulated net investment loss     (490,899 )  
Accumulated net realized gain on investments     12,419,577    
Net unrealized gain on investments     61,838,694    
Total net assets (equivalent to $19.64 per
share based on 21,749,270 shares outstanding)
  $ 427,062,303    

 

The accompanying notes are an integral part of these financial statements.

9



H&Q HEALTHCARE INVESTORS

STATEMENT OF OPERATIONS

For the Six Months Ended March 31, 2006

(Unaudited)

INVESTMENT INCOME:  
Dividend income (net of foreign
tax of $6,337)
  $ 84,344          
Special dividend     1,615,318          
Interest income from non affiliated issuers     767,265          
Interest income from affiliated issuers     29,900          
Total investment income         $ 2,496,827    
EXPENSES:  
Advisory fees   $ 2,451,307          
Legal fees     89,726          
Trustees' fees and expenses     85,601          
Accounting, administration and auditing fees     76,311          
Shareholder reporting     63,700          
Custodian fees     51,506          
Transfer agent fees     30,030          
Stock exchange listing fee     12,465          
Other (see note (3))     127,058          
Total expenses           2,987,704    
Net investment loss           ($ 490,877 )  
NET REALIZED AND UNREALIZED GAIN
ON INVESTMENTS:
 
Net realized gain on investments           $ 17,350,733    
Increase in net unrealized gain on investments             2,398,359    
Net realized and unrealized gain
on investments
          $ 19,749,092    
Net increase in net assets
resulting from operations
          $ 19,258,215    

 

The accompanying notes are an integral part of these financial statements.

10



H&Q HEALTHCARE INVESTORS

STATEMENTS OF CHANGES IN NET ASSETS

    For the six
months ended
March 31, 2006
(Unaudited)
  For the
year ended
September 30,
2005
 
NET INCREASE IN NET ASSETS
RESULTING FROM OPERATIONS:
 
Net investment loss   ($ 490,877 )   ($ 4,423,721 )  
Net realized gain on investments     17,350,733       34,435,090    
Increase in net unrealized
gain on investments
    2,398,359       32,609,585    
Net increase in net assets
resulting from operations
  $ 19,258,215     $ 62,620,954    
DISTRIBUTIONS TO SHAREHOLDERS
FROM:
 
Net realized capital gains   ($ 18,795,337 )   ($ 29,808,260 )  
CAPITAL SHARE TRANSACTIONS:  
Value of shares issued in
reinvestment of distributions
(522,229 and 846,596 shares,
respectively)
  $ 9,481,853     $ 15,001,802    
Net increase in net assets   $ 9,944,731     $ 47,814,496    
NET ASSETS:  
Beginning of period     417,117,572       369,303,076    
End of period   $ 427,062,303     $ 417,117,572    
ACCUMULATED NET INVESTMENT
LOSS INCLUDED IN NET ASSETS
AT END OF PERIOD
  ($ 490,899 )   ($ 22 )  

 

The accompanying notes are an integral part of these financial statements.

11



H&Q HEALTHCARE INVESTORS

STATEMENT OF CASH FLOWS

For the Six Months Ended March 31, 2006

(Unaudited)

CASH FLOWS PROVIDED FROM OPERATING ACTIVITIES:  
Purchases of portfolio securities   ($ 146,615,313 )  
Net maturities of short-term investments     13,350,253    
Sales of portfolio securities     143,690,688    
Interest income received     25,893    
Dividends received     1,694,172    
Operating expenses paid     (3,012,862 )  
Net cash provided from operating activities   $ 9,132,831    
CASH FLOWS USED FOR FINANCING ACTIVITIES:  
Cash distributions paid, net   ($ 9,313,484 )  
Net cash used for financing activities   ($ 9,313,484 )  
NET DECREASE IN CASH   ($ 180,653 )  
CASH AT BEGINNING OF PERIOD     253,029    
CASH AT END OF PERIOD   $ 72,376    
RECONCILIATION OF NET INCREASE IN NET ASSETS
RESULTING FROM OPERATIONS TO NET CASH
PROVIDED FROM OPERATING ACTIVITIES:
 
Net increase in net assets resulting from operations   $ 19,258,215    
Purchases of portfolio securities     (146,615,313 )  
Net maturities of short-term investments     13,350,253    
Sales of portfolio securities     143,690,688    
Accretion of discount     (769,814 )  
Net realized gain on investments     (17,350,733 )  
Increase in net unrealized gain on investments     (2,398,359 )  
Increase in interest receivable     (6,948 )  
Decrease in accrued expenses     (59,824 )  
Decrease in prepaid expenses     34,666    
Net cash provided from operating activities   $ 9,132,831    

 

Noncash financing activities not included herein consist of reinvested distributions of $9,481,853

Noncash operating activities not included herein consist of one conversion of restricted preferred stock with a cost of $3,008,325 to restricted common stock of the same issuer.

The accompanying notes are an integral part of these financial statements.

12



H&Q HEALTHCARE INVESTORS

FINANCIAL HIGHLIGHTS

(Selected data for each share of beneficial interest outstanding throughout the period indicated)

    For the six
months ended
March 31, 2006
  For the year ended September 30,  
    (Unaudited)   2005   2004   2003   2002(1)    2001  
Net asset value per share:
Beginning of year
  $ 19.65     $ 18.12     $ 19.63     $ 18.16     $ 27.35     $ 46.15    
Net investment loss (2)    ($ 0.02 )(3)    ($ 0.21 )   ($ 0.28 )   ($ 0.23 )   ($ 0.28 )   ($ 0.20 )  
Net realized and unrealized
gain (loss) on investments
    0.89       3.18       0.57       3.87       (5.73 )     (13.82 )  
Total increase (decrease)
from investment operations
  $ 0.87     $ 2.97     $ 0.29     $ 3.64     ($ 6.01 )   ($ 14.02 )  
Capital gain distributions
to shareholders
  ($ 0.88 )   ($ 1.44 )   ($ 1.80 )   ($ 2.17 )   ($ 3.18 )   ($ 4.78 )  
Net asset value per share:
End of period
  $ 19.64     $ 19.65     $ 18.12     $ 19.63     $ 18.16     $ 27.35    
Per share market value:
End of period
  $ 18.75     $ 18.64     $ 18.11     $ 17.66     $ 14.10     $ 21.74    
Total investment return
at market value
    5.52 %     11.56 %     12.99 %     43.49 %     (25.24 %)     (27.23 %)  
RATIOS AND SUPPLEMENTAL DATA:  
Net assets at end of period   $ 427,062,303     $ 417,117,572     $ 369,303,076     $ 286,754,854     $ 242,005,778     $ 329,373,206    
Ratio of operating expenses
to average net assets
    1.47 %*     1.56 %     1.63 %     1.65 %     1.64 %     1.42 %  
Ratio of net investment loss
to average net assets
    (0.24 %)*(3)      (1.17 %)     (1.42 %)     (1.27 %)     (1.16 %)     (0.62 %)  
Portfolio turnover rate     35.84 %     92.68 %     33.65 %     32.80 %     17.40 %     16.17 %  
Number of shares outstanding
at end of period
    21,749,270       21,227,041       20,380,445       14,608,952       13,323,483       12,042,064    

 

(1) In 2002, the Fund adopted the provisions of the AICPA Audit and Accounting Guide for Investment Companies and began accreting discounts and amortizing premiums on all debt securities. The effect of this change for the year ended September 30, 2002 was a decrease in net investment loss per share of $.009, an increase in net realized and unrealized loss on investments per share of $.009, and a decrease in the ratio of net investment loss to average net assets from (1.20%) to (1.16%). Per share data and ratios for the period prior to October 1, 2001 have not been restated to reflect this change in presentation.

(2) Net investment loss per share has been computed using average shares outstanding.

(3) Includes a special dividend from an issuer in the amount of $0.08 per share. Excluding the special dividend, the ratio of net investment loss to average net assets would have been (1.04%) annualized.

* Annualized.

The accompanying notes are an integral part of these financial statements.

13




H&Q HEALTHCARE INVESTORS

NOTES TO FINANCIAL STATEMENTS

March 31, 2006

(Unaudited)

(1)  Organization

H&Q Healthcare Investors (the Fund) is a Massachusetts business trust registered under the Investment Company Act of 1940 as a diversified closed-end management investment company. The Fund's investment objective is long-term capital appreciation through investment in securities of companies in the healthcare industries. The Fund invests primarily in securities of public and private companies that are believed to have significant potential for above-average growth. The Fund was organized on October 31, 1986 and commenced operations on April 22, 1987.

The preparation of these financial statements requires the use of certain estimates by management in determining the entity's assets, liabilities, revenues and expenses. Actual results could differ from these estimates. The following is a summary of significant accounting policies consistently followed by the Fund, which are in conformity with accounting principles generally accepted in the United States of America.

Investment Securities & Investment Income

Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. Exchange traded investments for which market quotations are not readily available is valued at fair value as determined in good faith by the Trustees of the Fund. The value of venture capital and other restricted securities is determined in good faith by the Trustees. However, because of the uncertainty of venture capital and other restricted security valuations, these estimated values may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material. See note 4 below. Short-term investments with maturity of 60 days or less are valued at amortized cost.

Investment transactions are recorded on a trade date basis. Gains and losses from sales of investments are recorded using the "identified cost" method. Interest income is recorded on the accrual basis, adjusted for amortization of premiums and accretion of discounts. Dividend income is recorded on the ex-dividend date.

Repurchase Agreements

In managing short-term investments the Fund may from time to time enter into transactions in repurchase agreements. In a repurchase agreement, the Fund's custodian takes possession of the underlying collateral securities, the market value of which is at least equal to the principal, including accrued interest, of the repurchase transaction at all times. In the event of default or bankruptcy by the other party to the agreement, realization and/or retention of the collateral by the Fund may be delayed or limited.

Federal Income Taxes

It is the Fund's policy to comply with the requirements of the Internal Revenue Code applicable to regulated investment companies and to distribute to its shareholders substantially all of its taxable income and its net realized capital gains, if any. Therefore, no Federal income or excise tax provision is required.

Distributions

The Fund records all distributions to shareholders from net investment income, if any, and realized gains on the ex-dividend date. Such distributions are determined in conformity with income tax regulations. Due to permanent book/tax differences in accounting for certain transactions, certain distributions may be treated as distributions from capital as opposed to distributions of net investment income or realized capital gains.

14



H&Q HEALTHCARE INVESTORS

NOTES TO FINANCIAL STATEMENTS

March 31, 2006

(continued)

Distribution Policy

Distributions will automatically be paid in newly issued shares of the Fund unless otherwise instructed by the shareholder. Pursuant to an SEC exemptive order, the Fund has implemented a fixed distribution policy that permits the Fund to make quarterly distributions at a rate of 2% of the Fund's net assets to shareholders of record. The Fund intends to use net realized capital gains when making quarterly distributions. This could result in a return of capital to shareholders if the amount of the distribution exceeds the Fund's net investment income and realized capital gains. It is anticipated that net realized capital gains in excess of the total distributed under this policy would be included in the December distribution.

Statement of Cash Flows

The cash amount shown in the Statement of Cash Flows is the amount included in the Fund's Statement of Assets and Liabilities and represents cash on hand at its custodian and does not include short-term investments at March 31, 2006.

Indemnifications

Under the Fund's organizational documents, its officers and Trustees may be indemnified against certain liabilities and expenses arising out of the performance of their duties to the Fund. Additionally, in the normal course of business, the Fund enters into agreements with service providers that may contain indemnification clauses. The Fund's maximum exposure under these agreements is unknown as this would involve future claims that may be made against the Fund that have not yet occurred. However, based on experience, the Fund expects the risk of loss to be remote.

(2)  Securities Transactions

The aggregate cost of purchases and proceeds from sales of investment securities (other than short-term investments) for the six months ended March 31, 2006 totaled $148,899,596 and $139,646,183 respectively.

At March 31, 2006, the total cost of securities for Federal income tax purposes was $367,868,100. The net unrealized gain for Federal income tax purposes on securities held by the Fund was $61,838,694, including gross unrealized gain of $108,696,352 and gross unrealized loss of $46,857,658.

(3)  Investment Advisory Fees and Other Transactions with Affiliates

The Fund has entered into an Investment Advisory Agreement (the Advisory Agreement) with Hambrecht & Quist Capital Management LLC (the Adviser). Pursuant to the terms of the Advisory Agreement, the Fund pays the Adviser a monthly fee at the rate when annualized of (i) 2.5% of the average net assets for the month of its venture capital and other restricted securities up to 25% of net assets and (ii) for the month, for all other assets, 1.0% of the average net assets up to $250 million, 0.9% of the average net assets for the next $250 million, 0.8% of the average net assets for the next $500 million and 0.7% of the average net assets thereafter. The aggregate fee may not exceed a rate when annualized of 1.375%. Beginning July 1, 2006 the Fund will pay a monthly rate when annualized of (i) 2.5% of the average net assets for the month of its venture capital and other restricted securities up to 25% of net assets and (ii) for the month, for all other assets, 0.98% of the average net assets up to $250 million, 0.88% of the average net assets for the next $250 million, 0.80% of the average net assets for the next $500 million and 0.70% of the average net assets thereafter. The aggregate fee may not exceed a rate when annualized of 1.375%

As of February 2005, Daniel R. Omstead, Ph.D, Christopher F. Brinzey, M.B.A., Frank T. Gentile, Ph.D. and Jason C. Akus, M.D./M.B.A. are members of the team that makes investments on behalf of the Fund. These members also perform other duties, including making

15



H&Q HEALTHCARE INVESTORS

NOTES TO FINANCIAL STATEMENTS

March 31, 2006

(continued)

investment decisions on behalf of another closed-end investment Company, H&Q Life Sciences Investors, which invests in the healthcare industries.

The Fund has entered into a Services Agreement (the "Agreement") with the Adviser. Pursuant to the terms of the Agreement, the Fund reimburses the Adviser for certain services related to a portion of the payment of salary and provision of benefits to the Fund's Chief Compliance Officer. During the six months ended March 31, 2006 these payments amounted to $54,817 and are included in the "other" category in the Statement of Operations together with insurance expenses of $49,181 incurred to unaffiliated entities. Such expenses are the major components of "other" in the Statement of Operations. Expenses incurred pursuant to the Agreement as well as certain expenses paid for by the Adviser are allocated in an equitable fashion to the Fund.

Certain officers and Trustees of the Fund are also officers of the Adviser. Trustees who are not affiliates of the Adviser receive an annual fee of $20,000 plus $500 for each Committee on which they serve and $500 for each meeting attended.

An affiliate company is a company in which the Fund holds 5% or more of the voting securities. Transactions with such companies all of which are venture capital companies, during the six months ended March 31, 2006 were as follows:

Issuer   Value on
October 1,
2005
  Purchases   Sales   Income   Value on
March 31,
2006
 
Agilix Corporation   $ 571,429     $     $     $     $ 571,429    
CardioNet, Inc.     5,820,004                   12,043       5,820,004    
Concentric Medical, Inc.     10,192,176                         10,192,176    
CytoLogix Corporation     755,703                   17,857       755,703    
OmniSonics Medical
Technologies, Inc.
    3,981,225                         3,981,225    
PHT Corporation     5,139,506                         5,139,506    
    $ 26,460,043     $ 0     $ 0     $ 29,900     $ 26,460,043    

 

(4)  Venture Capital and Other Restricted Securities

The Fund may invest in venture capital and other restricted securities if these securities would currently constitute 40% or less of net assets. The value of these securities represents 17% of the Fund's net assets at March 31, 2006.

During the year ended September 30, 2004, restricted securities from one issuer were exchanged for cash in connection with a corporate action, a portion of which has been retained by the issuer in an escrow account pending resolution of certain contingencies and whose estimated value of $684,509 at March 31, 2006 has also been determined by the Trustees. The value of the escrow account is included in the Receivable for Investments Sold in the Statement of Assets and Liabilities.

The following table details the acquisition date, cost, carrying value per unit, and value of the Fund's venture capital and other restricted securities at March 31, 2006, as determined by the Trustees of the Fund. With the exception of Conor Medsystems, Inc. Restricted common stock the Fund on its own does not have the right to demand that such securities be registered. Subject to certain conditions the Fund has the right to request registration of Conor Medsystems, Inc. Restricted common stock.

16



H&Q HEALTHCARE INVESTORS

NOTES TO FINANCIAL STATEMENTS

March 31, 2006

(continued)

Security(g)    Acquisition
Date
  Cost   Carrying Value
per Unit
  Value  
Agensys, Inc.  
Series C Cvt. Pfd.   2/14/02, 9/27/05   $ 3,307,024     $ 2.95     $ 3,300,300    
Agilix Corporation  
Series B Cvt. Pfd.   11/8/01     3,014,260       0.24       571,429    
Akorn, Inc.  
Restricted Common   3/7/06     2,600,001       4.13       2,386,801    
Avalon Pharmaceuticals, Inc.  
Restricted Common   10/22/01-2/11/05     3,217,655       4.80       995,155    
Aveta, Inc.      
Restricted Common   12/21/05     2,999,997       13.50       2,999,997    
CardioNet, Inc.  
Series C Cvt. Pfd.   5/3/01-3/25/03     5,551,349       3.50       5,520,004    
Convertible Note   8/15/05     300,000       1.00       300,000    
Ceres, Inc.  
Series C Cvt. Pfd.   12/23/98     1,502,620       6.00       2,250,000    
Series C-1 Cvt. Pfd.   3/31/01     111,488       6.00       193,158    
Series D Cvt. Pfd.   3/14/01     1,668,122       6.00       1,680,630    
Concentric Medical, Inc.  
Series B Cvt. Pfd.   5/7/02-1/24/03     3,329,210       1.40       6,794,116    
Series C Cvt. Pfd.   12/19/03     1,500,000       1.40       2,441,860    
Series D Cvt. Pfd.   9/30/05     957,768       1.40       956,200    
Conor Medsystems, Inc.  
Restricted Common   10/23/03-8/6/04     653,127       27.93       3,049,956    
Corus Pharma, Inc.  
Series C Cvt. Pfd.   4/8/04     3,002,344       0.58       1,500,000    
Cougar Biotechnology Inc.  
Series A Cvt. Pfd.   3/30/06     1,462,499       1.73       1,462,499    
Restricted Common   3/30/06     162,501       1.73       162,501    
CytoLogix Corporation  
Series A Cvt. Pfd.   1/13/98-7/21/99     1,622,895       0.83       399,984    
Series B Cvt. Pfd.   1/11/01     760,284       0.83       187,382    
Convertible Note   5/29/02     168,337       1.00       168,337    
Dako A/S  
Restricted Common   6/14/04     1,102,920       10.41       271,961    
EPR, Inc.  
Series A Cvt. Pfd.   3/9/94     1,000,409       0.01       2,222    
Galileo Pharmaceuticals, Inc.  
Series F-1 Cvt. Pfd.   8/18/00     3,002,895       0.00       140    
I-trax, Inc.  
Series A Cvt. Pfd.   3/18/04     4,003,650       34.90       5,584,000    
Labcyte, Inc.  
Series C Cvt. Pfd.   7/18/05     1,923,506       0.52       1,920,000    
Masimo Corporation  
Series D Cvt. Pfd.   8/14/96     1,120,224       11.00       1,760,000    
Restricted Common   3/31/98     0       0.01       1,600    
Medwave, Inc.  
Restricted Common   2/21/06     2,275,000       3.24       2,690,146    
OmniSonics Medical Technologies, Inc.  
Series B Cvt. Pfd.   5/24/01     2,409,023       1.34       2,181,224    
Series C Cvt. Pfd.   10/1/03     1,800,336       1.16       1,800,001    
PHT Corporation  
Series D Cvt. Pfd.   7/23/01     4,205,754       0.78       4,200,000    
Series E Cvt. Pfd.   9/12/03-10/14/04     941,669       0.78       939,506    
Raven biotechnologies, Inc.  
Series B Cvt. Pfd.   12/12/00     3,001,725       0.83       1,509,091    
Series C Cvt. Pfd.   11/26/02     2,331,600       0.83       2,331,600    
Series D Cvt. Pfd.   6/23/05     1,205,415       0.29       1,200,000    
Songbird Hearing, Inc.  
Restricted Common   12/14/00     3,004,861       0.01       2,085    

 

17



H&Q HEALTHCARE INVESTORS

NOTES TO FINANCIAL STATEMENTS

March 31, 2006

(continued)

Security(g)    Acquisition
Date
  Cost   Carrying Value
per Unit
  Value  
Syntiro Healthcare Services  
Restricted Common   2/5/97   $ 1,200,325     $ 0.001     $ 306    
TargeGen, Inc.  
Series C Cvt. Pfd.   8/30/05     2,763,306       1.30       2,760,000    
Therion Biologics Corporation  
Series A Cvt. Pfd.   8/20/96-10/16/96     444,850       1.22       57,837    
Series B Cvt. Pfd.   6/22/99     901,393       1.22       292,800    
Series C Cvt. Pfd.   9/26/01-10/15/01     1,529,348       1.22       497,409    
Series C-2 Units   8/13/03     59,998       1.22       40,665    
Sinking Fund Cvt. Pfd.   10/18/94-8/20/96     721,291       0.01       361    
Restricted Common   7/12/90-1/25/96     511,365       0.01       2,268    
TherOx, Inc.  
Series H Cvt. Pfd.   9/11/00     3,002,506       3.80       247,825    
Series I Cvt. Pfd.   7/8/05     579,407       3.86       577,100    
Xanthus Life Sciences, Inc.  
Series B Cvt. Pfd.   12/5/03-3/23/06     2,556,320       1.00       2,555,000    
Zyomyx, Inc.  
Series A New Cvt. Pfd.   1/12/04     299,700       0.10       30,000    
Series B New Cvt. Pfd.   2/19/99-1/12/04     468       0.10       30    
New Restricted Common   2/19/99-7/22/04     3,602,065       0.01       3,000    
        $ 89,392,810             $ 70,778,486 (h)   

 

(g)  See Schedule of Investments and corresponding footnotes for more information on each issuer.

(h)  Represents 17% of the Fund's net assets as of March 31, 2006.

(5)  Sources of Net Assets

The changes in the sources of net assets for the period from October 1, 2005 through March 31, 2006 are as follows:

    Capital Paid
in on Shares
of Beneficial
Interest
  Accumulated
Net
Investment
Loss
  Accumulated
Net Realized
Gain on
Investments
  Net
Unrealized
Gain on
Investments
  Total Net
Assets
 
As of October 1, 2005:   $ 343,813,078     ($ 22 )   $ 13,864,181     $ 59,440,335     $ 417,117,572    
For the period from
October 1, 2005 through
March 31, 2006:
 
Net investment loss             (490,877 )                     (490,877 )  
Net realized gains                     17,350,733               17,350,733    
Distributions, net of
reinvestments paid
                    (18,795,337 )             (18,795,337 )  
Value of shares issued in
reinvestment of dividends
    9,481,853                               9,481,853    
Increase in net unrealized
gain on investments
                            2,398,359       2,398,359    
As of March 31, 2006:   $ 353,294,931     ($ 490,899 )   $ 12,419,577     $ 61,838,694     $ 427,062,303    

 

18




H&Q HEALTHCARE INVESTORS

PRIVACY NOTICE

If you are a registered shareholder of the Fund, the Fund and Hambrecht & Quist Capital Management LLC, the Fund's investment adviser, may receive nonpublic personal information about you from the information collected by the transfer agent from your transactions in Fund shares. Any nonpublic personal information is not disclosed to third parties, except as permitted or required by law. In connection with servicing your account and effecting transactions, the information received may be shared with the investment adviser and non-affiliates, including transfer agents, custodians or other service companies. Access to your nonpublic personal information is restricted to employees who need to know that information to provide products or services to you. To maintain the security of your nonpublic personal information, physical, electronic, and procedural safeguards are in place that comply with federal standards. The policies and practices described above apply to both current and former shareholders.

If your Fund shares are held in "street name" at a bank or brokerage, we do not have access to your personal information and you should refer to your bank's or broker's privacy policies for a statement of the treatment of your personal information.

FOR MORE INFORMATION

A description of the Fund's proxy voting policies and procedures and information on how the Fund voted proxies and relating to portfolio securities during the most recent 12-month period ended June 30, is available (i) without charge, upon request by calling 1-800-451-2597; (ii) by writing to Hambrecht & Quist Capital Management LLC at 30 Rowes Wharf, Boston, MA 02110-3328; (iii) on the Fund's website at www.hqcm.com; and (iv) on the Securities and Exchange Commission's website at www.sec.gov.

The Fund's complete Schedule of Investments for the first and third quarters of its fiscal year will be filed quarterly with the Securities and Exchange Commission ("SEC") on Form N-Q. This Schedule of Investments will also be available on the Fund's website at www.hqcm.com, or the SEC's website at www.sec.gov. The Fund's Form N-Q may be reviewed and copied at the SEC's Public Reference Room in Washington, DC or by calling 1-800-SEC-0330.

19



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H&Q HEALTHCARE INVESTORS

New York Stock Exchange Symbol: HQH

30 Rowes Wharf, 4th Floor
Boston, Massachusetts 02110-3328
(617) 772-8500
www.hqcm.com

Officers

Daniel R. Omstead, Ph.D., President
Kathleen Eckert, Secretary, Treasurer and Chief Compliance Officer

Trustees

Lawrence S. Lewin

Robert P. Mack, M.D.

Eric Oddleifson

Daniel R. Omstead, Ph.D

Oleg M. Pohotsky

Uwe E. Reinhardt, Ph.D.

Henri A. Termeer

Investment Adviser

Hambrecht & Quist Capital Management, LLC

Administrator & Custodian

State Street Bank and Trust Company

Transfer Agent

Computershare Shareholder Services, Inc.

Legal Counsel

Dechert LLP

Shareholders with questions regarding share transfers may call

1-800-426-5523

Daily net asset value may be obtained from

our website (www.hqcm.com) or by calling

1-800-451-2597

HQH-SAR-06




 

Item 2.                                   CODE OF ETHICS.

 

Not applicable to this semi-annual filing.

 

ITEM 3.                             AUDIT COMMITTEE FINANCIAL EXPERT.

 

Not applicable to this semi-annual filing.

 

ITEM 4.                             PRINCIPAL ACCOUNTANT FEES AND SERVICES.

 

Not applicable to this semi-annual filing.

 

ITEM 5.                             AUDIT COMMITTEE OF LISTED REGISTRANTS.

 

No applicable to this semi-annual filing.

 

ITEM 6.                             SCHEDULE OF INVESTMENTS.

 

The Registrant’s Schedule of Investments is included as part of the Report to Shareholders filed under Item 1 of this form.

 

ITEM 7.                        DISCLOSURE OF PROXY VOTING POLICIES AND PROCEDURES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

 

Not applicable to this semi-annual filing.

 

ITEM 8.                             PORTFOLIO MANAGERS OF CLOSED-END MANAGEMENT INVESTMENT COMPANIES

 

Not applicable to this semi-annual filing.

 

ITEM 9.                        PURCHASES OF EQUITY SECURITIES BY CLOSED-END MANAGEMENT INVESTMENT COMPANY AND AFFILIATED PURCHASERS.

 

None.

 

ITEM 10.                      SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

 

There have been no material changes to the procedures by which the shareholders may recommend nominees to the registrant’s Board of Trustees, where those changes were implemented after the registrant last provided disclosure in response to the requirements of Item 7(d)(2)(ii)(G) of Schedule 14A, or this Item.

 

ITEM 11.                      CONTROLS AND PROCEDURES.

 

(a)              In the opinion of the principal executive officer and principal financial officer, based on their evaluation which took place within 90 days of this filing, the Registrant’s disclosure controls and procedures are adequately designed and are operating effectively to ensure (i) that material information relating to the Registrant, including its consolidated subsidiaries, is made known to them by others within those entities, particularly during the period in which this report is being prepared; and (ii) that information required to be disclosed by the registrant on Form N-CSR is recorded, processed, summarized and reported within the time period specified in the Securities and Exchange Commission’s rules and forms.

 

(b)             There were no changes in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent fiscal half-year that may have materially affected or are reasonably likely to materially affect, the Registrant’s internal control.

 

ITEM 12.                      EXHIBITS

 

(a)(1)  Code of Ethics: Not applicable to this semi-annual filing.

 

(a)(2)  Certification: Filed as an attachment to this filing.

 



 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

(Registrant)

H&Q HEALTHCARE INVESTORS

 

 

By (Signature and Title)*

/s/ Daniel R. Omstead

 

Daniel R. Omstead, President

Date:

6/5/06

 

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

 

By (Signature and Title)*

/s/ Kathleen Eckert

 

Kathleen Eckert, Treasurer

Date:

6/5/06

 

 

By (Signature and Title)*

 

 

 

Date:

 

 


* Print the name and title of each signing officer under his or her signature.